RT @Theo_BrainC_lab: Carcinogenesis: Mice with targeted Pi3k-Pten mutations develop tumors resembling an aggressive….

@dinevska_marija & @Theo_BrainC_lab This review is special bcs we love spatial biology & want to contribute to expanding the treatment choices for patients & their families. Special thanks to @marianna_raps and @martinelliadr for the collaboration and insights.

We have used some of these technologies to demonstrate preferential distribution of T-cells in ECM-rich regions in both primary & metastatic brain tumours.

We then discuss how spatial technology has been used in retrospective clinical research & the potential for spatial technology to become an important tool to define cell types & mechanisms in the brain tumour microenvironment which can be targeted to enhance immunotherapy.

We also highlight how this technology can be overlayed with traditional histopathological stains, including H&E and Masson's trichrome to investigate key histological hallmarks of brain cancer, such as hypoxia, necrosis & extracellular matrix stroma.

In our review we cover commonly used multiplex antibody-based & transcriptomic spatial technologies & computational tools.

We share our review discussing several key studies investigating the immunosuppressive tumour microenvironment, with a focus on brain cancer​. @dinevska_marija @Theo_BrainC_lab.

Thanks Theo, I’m looking forward to seeing this research in press too!.

Thanks Marija, I wouldn’t have made it this far without your support!.

RT @Theo_BrainC_lab: Back at #lornecancer! Highlight was @michelle_monje 's neuro-glioma talk! photo with fabulous researchers @samuelsw @….

RT @Theo_BrainC_lab: Our review on how a master transcriptional regulator of brain function & immunity, CREB, is co-opted to support brain….

RT @dinevska_marija: If you're interested in the spatial analysis of spheroids/organoids/tumorspheres,.check out our new published protocol….

RT @Theo_BrainC_lab: #Glioblastoma initiation visualized using @AkoyaBio Phenocycler 2.0 showing transition of neural #stemcells into #GBM….

RT @Theo_BrainC_lab: Incredible depth & clarity of mouse brain & mouse brain tumor tissue using @AkoyaBio Phenocycler-Fusion 2.0 combining….

RT @BerrocalRubio: Today at the Melbourne Brain Symposium, presenting our multi-omics approach to characterize the molecular diversity of t….

A great conference with a diverse range of speakers with the same focus of tackling cancer. I felt honoured to be given the opportunity to share my PhD work, thanks to the organisers @VCCCAlliance #VCCCA23.

RT @Theo_BrainC_lab: @UniMelbMDHS PhD graduate researchers @samuelsw & @dinevska_marija @ #EACR2023 Torino, presenting their fabulous disco….

@dinevska_marija and I will be presenting our posters on investigating the cellular and transcriptional mechanisms regulating tumor immunosuppression in glioblastoma & metastatic brain cancer. Find us at P-0515 and P-0533. #EACR2023 @Theo_BrainC_lab

I am grateful to the @EACRnews for the travel award, which enabled me to present my research at #EACR2023 Congress in Torino, Italy.

First time sharing my research live, on-air on @einstein_agogo @3RRRFM. It was a fantastic experience, thanks to @DrShaneRRR. It was also great meeting 20 other superb science communicators. #20PhDsin20mins.