Dr Sam Soete
@sam_soete
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Decentralized Health Optimization with an evolutionary lens. Mitochondria are all. Not medical advice.
Belgium
Joined May 2020
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You will be given a vitamin D supplement, which will raise your LDL, then they will give you a statin, which will impair your mitochondria, then you will be given metformin, duloxetine or pregabalin, and on the cycle goes.
Really, all you needed was some sun.
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Statins are nuking your mitochondria.
This 🧵explores how statins impact our metabolic pathways and how this relates to the side-effects people experience.
#Statins
#Mitochondria
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Nutrition for Mitochondrial Function Omega Thread:
This 🧵will shine a light on why I prioritise micronutrient density.
Mitochondrial function relies on optimal nutrient levels as they play pivotal roles in driving energy metabolism and ATP production.
(Bookmark this)
THREAD
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Mitochondria lie at the heart of chronic, neolithic disease.
This 🧵explores the mitochondrial paradigm of degenerative disease pioneered by Doug Wallace.
This shit is interesting... And the implications are unimaginable.
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Sunlight is a gift.
UVB = Vitamin D
UVB = Testosterone
UVB = Melanin
UVB = β-Endorphins
UVB = Analgesic
UVB = Leptin Sensitivity
UVB = Weight-Loss
UVB = Anti-Viral & Anti-Bacterial
UVA = Nitric Oxide = Blood Pressure Regulation
IRA = Melatonin Production
IRA =
☀️ What's the current idea about sunlight exposure?
Seems there's two movements
🧴 The classic movement says sunlight is bad, skin cancer, avoid it, stay in shadow, use sunscreen
🌞 The new movement says that was a psyop and sunlight is great, lack of sunlight killed lots of
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Taurine & Mitochondrial Function
In in-depth🧵exploring how taurine improves mitochondrial health, and why it matters for metabolic disease, diabetes and heart disease.
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Are you in the sun all day but still can’t make vitamin D?
Let me explain one reason why.
Cholesterol is turned into vitamin D through photoisomerization. It requires UV sunlight, but it also requires WATER.
If you are dehydrated on the cellular level, you will struggle to
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Why leptin resistance → insulin resistance:
A key function of leptin is to prevent fat from being deposited inappropriately in cells such as myocytes.
It does this by activating UCP3 in mitochondria and uncoupling oxidative phosphorylation which burns off the excess calories
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Seed Oils Are Nuking Your Mitochondria:
This 🧵explores the underlying mechanisms underpinning the consumption of Ω-6 fatty acids and mitochondrial dysfunction.
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My testosterone is 1138ng/dl and I have never taken a single supplement in my life.
So what did I do?
🛌 Optimized sleep (9pm-5am +1hr in winter)
🔆 Maximised sunlight exposure
🌒 Kept my circadian rhythms in sync
🥩 Micronutrient dense diet (animal based)
🚴♂️ Exercised
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Every sleep tip I could come up with after being an insomniac for 7 years in medical school.
Habits
1. Maintain a consistent sleep schedule, even on weekends (nature doesn't care about weekends)
2. Aim for bedtime between 9:30-10:30 pm and wake up between 6-8 am.
3. Establish a
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I believe most people are doing intermittent fasting wrong.
The common approach is to skip breakfast, but I think we should be skipping dinner, or having it earlier in the day. This makes more sense from a circadian health perspective.
A study found that those who front
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How I transformed from a devitalized medical student to a decentralized doctor.
A cathartic 🧵 about my story through medical school and life.
This is a deeply personal compilation of self-reflections.
I trust you.
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How I fixed my lower back pain:
For the past 11 months I have struggled with debilitating chronic lower back pain. It is gone now.
This 🧵explains the pitfalls, revelations and lessons I learned to overcome it.
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Taurine is the most abundant amino acid in testicles.
But production in testes drops with age.
Taurine acts as a potent antioxidant in the testes, and also modulates the HPG axis and upregulates LH production.
Supplementation in animal studies has shown to increase
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Imagine a hospital where all beds are grounded, all lighting is circadian friendly, windows are opened, patients are brought outside, food is seasonal, local and unprocessed, noise pollution is minimal.
This is the way.
Are you building this
@DrJackKruse
@nayibbukele
?
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SPF 8 sunscreen reduces vitamin D production by 97.5%
SPF 15 reduces vitamin D production by 99.9%
(Studies by Michael Holick)
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Rise with the sun. Eat real food. Lift heavy things. Move your body both slow and fast. Stretch your muscles and your mind. Work hard on what gives you purpose. Move towards your fears. Tell the truth. Don't fool yourself. Read what inspires you. Study what intrigues you. Say
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Are we to believe that light is important for one of these, and not the other?
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THE SUN IS NATURE'S OZEMPIC
Let me tell you how.
People think it's absurd that sunlight can control metabolism and lead to fat loss.
But everyone already knows this to be true by conceding one fact:
UV light = Tan (melanin production).
All you need to do now is understand
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Master Thread on Statins: The Four Horsemen
1) How statins nuke your mitochondria
2) How statins cause T2DM
3) How statins cause CVD
4) How statins cause cardiomyopathy
#statins
#bigpharma
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Leptin Sensitivity & Melatonin Are Intertwinned:
This is an unbelievably important connection to understand.
Let's dive into why & how a deficiency in melatonin production can lead to leptin resistance = obesity, nuked metabolism & chronic hunger.
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Mainstream medicine always focuses on macronutrients: carbs, protein, fat
When you realize that you need an abundance of micronutrients to process and utilize these macronutrients, you will look at food differently
Empty calories are macronutrients that lack the necessary
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Mitochondria: An Epic Origin Story
What are they? Where do they come from? And why are they here?
This 🧵unravels the mystery behind the origins of the most important and enigmatic organelle in our body.
#mitochondria
#metabolism
#science
#biology
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Our circadian rhythm is entrained by environmental cues acting on sensors within the retina containing melanopsin.
Melanopsin is a photopigment and blue light chromophore found in the intrinsically photosensitive retinal ganglion cells (ipRGC)s that is sensitive to 446-483nm
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Why is sunlight beneficial for improving sleep?
There are many reasons, but one key reason is that melatonin production at night requires adequate sunlight exposure during the day.
Tryptophan → Serotonin → Melatonin
The conversion of tryptophan to serotonin is activated by
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I have never been more tanned.
I have also never been leaner, or more happy.
When you understand the relationship between the sun and leptin.
And the fact that melanin breaks down into dopamine,
It begins to make sense.
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“Before you heal someone, ask him if he's willing to give up the things that make him sick.”
― Hippocrates
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Statins, given like Halloween candy to those with >10% risk of CVD, can cause insulin resistance & diabetes.
A prime example of "double think".
This 🧵 explores how statins impede insulin sensitivity & damage our pancreas.
#statins
#diabetes
#T2DM
#CVD
#cholesterol
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Leptin follows a circadian rhythm.
It increases in the evening and peaks during the first hours of sleep. This prevents you from being hungry before bed.
If you are craving food at night, it is a sign of leptin resistance.
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Primer on Mitochondrial Dysfunction & Disease:
Lets take a step by step look at how a mitochondria functions (the basics), and how it's malfunctioning can lead to disease and aging.
1) Oxidative Phosphorylation (OXPHOS):
A process that couples the transfer of electrons
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On ADHD:
"By the time a child on drugs reaches puberty, he does not know what his undrugged personality is."
- Mark Stewart
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Melatonin will reduce ghrelin (hunger hormone) and increase leptin sensitivity (satiety hormone).
Optimising your circadian biology can solve obesity.
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Sunlight will balance your hormones in a way that supplementing can't
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Grounding is not just about absorbing electrons from the Earth.
The oscillation in the Earth's negative potential acts as a Zeitgeber for the body's internal clocks.
That is partly why grounding can normalise cortisol rhythms.
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Sunlight for Fat Loss:
1. Mechanism of light impacting fat?
• Fat cells are most responsive to blue light
• Fat tissue expresses OPN4 gene coding for melanopsin (same photoreceptor in the retina that entrains our circadian rhythms)
• Fat tissue express TRPC channels
2. Does
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The Link Between Mitochondria & Oxidative Stress:
Warning: This is a detailed dive into the inner workings of the mitochondrion, probably only for those who are really interested.
Reactive oxygen species (ROS) are produced as a toxic by-product of ATP synthesis. They have
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Melanocortin 4 receptors (MC4Rs) in the hypothalamus are key regulators of male sexual function.
When these receptors are activated, erectile activity “is dramatic”.
Leptin→POMC→alpha-MSH→MC4R
Leptin sensitivity is crucial for male (and female) sexual function.
Another
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Circadian Health → SCN → Pineal Gland → Melatonin → Hypothalamus → GnRH → Pituitary → LH & FSH → Estrogen & Testosterone → Reproductive Health
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Here is a beautifully detailed diagram showing you which micronutrients act where.
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Melanin has a negative charge allowing it to chelate positively charged particles such as heavy metals and microplastics. This gives it a detoxifying function. Melanin sequesters toxins in the skin from inside the body, which will be removed when the skin is sloughed.
Melanin by way of POMC and sunlight
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Natural sunlight can be up to a x100 brighter than indoor spaces.
We need bright light during the day, especially in the morning to entrain our circadian rhythms and have all our bodily systems synchronised.
Going outside is free and accessible to everyone, nobody profits but
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Watching sunrise every morning is the cornerstone of reclaiming your circadian health.
It's free.
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Everybody wonders how much sunlight we need, and how much is too much...
There is no risk of synthesising too much vitamin D from sunlight, the body has built in mechanisms to regulate production.
Once adequate previtamin D is produced via UV induced photoisomerization of
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Improve your health as fast as you can, but as slow as you have to
Be patient, things take time to heal, indeed, it took decades of abuse for things to get this bad in the first place
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The liver does not store toxins.
It metabolises and detoxifies them.
What it does store is myriad nutrients at levels unparalleled in any other food.
Beef liver must be a joke from the health and fitness industry to pass off one of the most disgusting and damaging foods as healthy.
You are literally eating an animal’s sewage treatment plant.
It doesn’t taste good for a reason.
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Fluoride accumulation accumulates in pineal gland and disrupts circadian rhythms
"Parental fluoride exposure disrupts the circadian rhythm, causes anxiety-like behaviour's, and decreases the levels of brain antioxidant enzymes and melatonin"
Drink glass-bottled water and use
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Centralised medicine misses 3 key pieces to the equation (obvs there are more) that cost nothing and do need not interfere with conventional treatments:
1. Sunlight ☀️
2. Circadian Health 🌗
3. Grounding 🌏
There is no excuse for not incorporating them into a health plan.
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If you enjoyed this content and want to learn more about
#metabolism
:
1. Follow me for more content about mitochondria.
2. Like and Retweet this thread
Statins are nuking your mitochondria.
This 🧵explores how statins impact our metabolic pathways and how this relates to the side-effects people experience.
#Statins
#Mitochondria
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Acetyl L-Carnitine improves leptin sensitivity and mitochondrial function.
Guess where it is found?
Meat.
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Seafood is rich in DHA but also high in heavy metals like mercury… so do we stop there?
No, we add nuance.
Eat fish that have a high DHA:Heavy Metal ratio like wild caught salmon, sardines, trout, and raw oysters.
Maximise your detoxification pathways through:
- Liver
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Theory Underpinning High Blood Pressure
Primary (or essential) hypertension refers to high blood pressure typically from unknown cause.
But just because centralised medicine does not understand the underlying mechanism, does not mean there is one.
Blood viscosity (tendency
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Sleeping grounded increases melatonin production and resynchronizes cortisol rhythms.
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Rope flow has been my way of "touching grass" these past few months.
It grounds me, clears my mind and brings me to the present moment.
Figure out what this is for you, and do it daily.
This is the way.
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Cholesterol acts as an intermediate for steroid hormones, bile acids and vitamin D, CoQ10 and is crucial to the integrity of all cell membranes.
This partly explains the plethora of statin-associated symptoms (SAS) that manifest in up to 30% of patients.
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Chronic disease is not a genetic story.
Genetic mutations cannot explain the meteoric rise of chronic disease in recent decades. The problem lies not in our genes, but in our environment.
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Carbohydrate metabolism generates more ROS. This leads to mitochondrial DNA mutations and ultimately cell death.
So are carbs always bad? No.
ROS serve as important signalling molecules that dictate epigenetic alterations. They just need to be signalled at the right time, in
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Red light therapy appears to be more effective than cryotherapy for augmenting muscle recovery after intense exercise
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1. Statins cause CoQ10 depletion.
CoQ10 has high antioxidant activity and regenerates other antioxidants such as vitamin C & vitamin E.
A deficiency in CoQ10 is associated with heart failure, nephrotic syndrome, muscular and neurological disorders.
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The Mitochondrial Origin for Type 2 Diabetes Mellitus
This 🧵will explore the thesis that insulin resistance and subsequent T2DM is caused by mitochondrial dysfunction.
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Micronutrients & molecules crucial to mitochondrial function include:
• B vitamins
• Vitamin C
• Vitamin E
• Selenium
• Zinc
• Magnesium
• CoQ10
• Carnitine
• Taurine
• ALA
• Creatine phosphate
• Nitrate
• Melatonin
• Caffeine
and more...
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Statin-associated muscle symptoms (SAMS) manifest in the form of muscle weakness, muscle fatigue, pain, tendon pain, cramping and rhabdomyolysis.
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Statins are known to deplete CoQ10, impair mitochondrial function and are linked with low energy & fatigue.
"To our knowledge, this is the first randomized evidence affirming unfavourable statin effects on energy and exertional fatigue.
Effects were seen in a generally
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A Day of Sunlight
The sunrise is predominately near-infrared (NIR) photons which stimulates high levels of mitochondrial melatonin synthesis.
The ratio of NIR/Visible light is approximately 3 to 1 at sunrise, reaching 1 to 1 at noon, returning to 3 to 1 at sunset.
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14 Ways To Increase Sun Exposure At Work
This is for everyone working on office job, or is indoors during the day and wants to improve their health by leveraging the sun
THREAD 🧵
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There is great evolutionary wisdom to be found in ancient cultural practices.
Societies of old prepared their corn by boiling in an alkaline solution, such as lime juice, a process now referred to as nixtamalization.
Nixtamalized corn enhances the nutritional value with a more
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If I described myself, it would sound something like this:
An introvert who enjoys time alone, peace, quiet, order and the time to investigate and dive deep in any topic that intrigues me - slowly but deliberately putting the puzzle pieces together.
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The effect taurine has on mitochondrial function is huge.
1) Mitochondrial Protein Formation
2) ATP Synthesis
3) Oxidative Stress reduction
4) Calcium Regulation
5) Apoptosis regulation
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The carb vs no carb debate becomes simple when you understand chronobiology.
For example, insulin sensitivity increases in the summer, and decreases in the winter.
Truth is found in nuance not dogmatism.
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My 6 years in medical school were spent learning about disease.
Every since I graduated, I have been diving into what constitutes health.
The former keeps you alive longer while being sick. The latter creates vitality.
Health Paradigm > Disease Paradigm
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Florence Nightingale: “It is the unqualified result of all my experience with the sick, that second only to their need of fresh air is their need of light”
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Centralized vs Decentralized Medicine:
The allopathic medical system operates on centralized guidelines that are subject to mal-incentives. The game-theory and memetic traits involved in their design lead to them having one primary output: drug prescription.
It does not aim to
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Statins act by reversibly and competitively inhibiting HMG-CoA reductase, a key enzyme in the mevalonate pathway of which cholesterol is a final product.
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High Protein To Lose Weight:
Everyone always says that a high protein diet is beneficial for weight-loss, but never tell you why...
This 🧵will explore all of the mechanisms behind protein's weight-loss benefits.
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All the genes that melatonin targets
When you see this, you realise you are dealing with something important
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Vitamin K Omega Thread:
Want to know why everyone combines vitamin D supplementation with vitamin K?
This 🧵goes deep into the mechanisms of action of vitamin K, and its synergistic relationship with vitamin D in preventing vascular calcification and maintaining BMD.
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Any protocol or treatment that cost nothing will inevitably be underrepresented within the scientific literature.
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@LoriCot60821257
This is often a marker of circadian dysregulation and leptin resistance. Morning appetite returning is a sign of improved circadian health!
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Making dinner for the family, teaching them about circadian health
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Interestingly, animal foods are the sole supply of taurine. Seafood (especially), meat and eggs are rich in taurine.
This is a big problem for vegans and vegetarians.
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Why don’t doctors know about leptin?
Because they haven’t been given leptin as a drug to prescribe.
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Unveiling the Paradox: Do Statins Fuel the Fire of Heart Disease?
This is a deep dive 🧵into the mechanistic relationship between statins and coronary heart disease.
#statins
#CVD
#heartdisease
#cholesterol
#mitochondria
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For every 100 lux increase of daylight in patient rooms, duration in hospital falls by 7.3hrs
How about that
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The reliance of skeletal muscle on energy consumption places mitochondrial dysfunction at the epicentre of SAMS pathogenesis.
This is evidenced by the high blood Lactate/Pyruvate ratio and impaired metabolic recovery observed in statin users.
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Why melatonin is the OG Antioxidant:
1) It can scavenge up to 10 ROS vs traditional antioxidants like vitamin C that cap at 1 or 2.
2) Melatonin metabolites also act as antioxidants.
3) Melatonin has minimal prooxidant activity compared to classical antioxidants.
4) Melatonin
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Increasing calcium intake can improve leptin sensitivity due to its role in regulating the agouti gene.
This gene amplifies leptin production from fat cells while blocking the brain's ability to sense leptin, resulting in leptin resistance, increased fat storage, and inhibited
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@drkohilathas
It is no measure of health to be well adjusted to a profoundly sick society.
- Jiddu Krishnamurti
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Lipophilic statins such as simvastatin result in a significant decrease in mtDNA.
Interestingly, vitamin D supplementation prevents the depletion of mtDNA.
Maybe this is because vitamin D upregulates the biosynthesis of CoQ10, and also has antioxidant properties.
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We have smoke breaks, when will businesses incorporate sunlight breaks?
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Expose as much of your body to the sun as you can. Get naked.
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The majority of CoQ10 circulates bound to ApoB containing lipoproteins.
The inhibition of the mevalonate pathway by statins causes secondary CoQ10 depletion by 16-54%.
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Seems like grounded sleeping at night may aid mitochondrial uncoupling, increasing basal metabolic rate, thermogenic effect
This would lead to weight loss and improved mitochondrial function
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Vitamin D synthesised through sunlight has an automatic dose regulation system embedded within it.
You cannot overdose on vitamin D from the sun.
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High blood pressure?
Total peripheral resistance is a product of vessel diameter and viscosity.
Grounding takes care of viscosity by increasing RBC zeta potential.
Sunlight takes care of diameter by releasing nitric oxide.
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