RNA4T: RNA for therapy
@rna4t_opjak
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Project RNA4T: RNA for therapy brings together 14 research groups from @IOCBPrague @imgprague @ceitec_brno @BiologyCentre @science_charles & MBU CAS
Czech Republic
Joined April 2024
RT @hocekm: Our newest paper on enzymatic incorporation of 2-substituted adenine nucleotides into RNA and their use for RNA labeling has be….
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RT @hocekm: Our newest paper on enzymatic synthesis of hypermodified DNA bearing functional groups mimicking amino acid side chains in enzy….
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RT @hocekm: Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA displaying 4 different cationic groups just published….
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RT @hocekm: Our new paper (with P. Rezacova group) on the use of environment-sensitive fluorescent nucleotide in DNA probes for identific….
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RT @IOCBPrague: #research.Enzymatic synthesis of reactive RNA probes containing squaramate-linked cytidine or adenosine for bioconjugations….
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RT @hocekm: Ambra Spampinato has successfully defended her PhD thesis entitled: Modified Nucleotides and DNA Bearing reactive Groups for….
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RT @hocekm: Our newest paper on bacteriophage-related epigenetic pyrimidine nucleotides and their influence on transcription with T7 RNA po….
nature.com
Communications Chemistry - DNA modifications on pyrimidine nucleobases play diverse roles in biology such as protection of bacteriophage DNA from enzymatic cleavage, however, their role in the...
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Mycobacterial HelD connects RNA polymerase recycling with transcription initiation
nature.com
Nature Communications - This study provides mechanistic insights into how the mycobacterial transcription factor HelD gradually dissociates from RNAP during transcription initiation and protects...
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New paper by the Stefl group: Linhartova, K. et al. Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7. Nat Commun 15, 9163 (2024).
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RT @CEITEC_Brno: Yesterday,#RNAClub2024 took place at @CEITEC_Brno,featuring excellent talks, inspiring guests, engaging poster presentatio….
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RT @CEITEC_Brno: Today, we are excited to continue our work in #RNA with the launch of a new project – RNA4T: RNA for Therapy. We look forw….
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RT @CahovaB: A new PhD is among us! Congratulations to @BiancaMariaMit2 on her successful thesis defense and thanks for all your hard work….
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Differential effects of 40S ribosome recycling factors on reinitiation at regulatory uORFs in GCN4 mRNA are not dictated by their roles in bulk 40S recycling
nature.com
Communications Biology - A study of ribosome recycling in the budding yeast shows that 40S subunit recycling factors influence translation reinitiation independently of their function in bulk...
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RT @hocekm: Our newest paper on reactive modification of DNA for crosslinking and bioconjugation with Trp-containing peptides and proteins….
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RT @ChemEurope: Our Pick of the Week, out #OpenAccess in @ChemEurJ by @hocekm & team at @IOCBPrague and @Akademie_ved_CR:. Glyco-DNA: Enzym….
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Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II | Journal of Virology
journals.asm.org
Understanding the intricate interactions between influenza A viruses and host proteins is crucial for developing targeted antiviral strategies. This study employs advanced imaging techniques to...
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RT @CahovaB: We wrote a review about non-canonical #RNA caps and all they do (or don't do). From methylated 5' phosphates to #Ap4A, #NAD, #….
tandfonline.com
RNA capping is a prominent RNA modification that influences RNA stability, metabolism, and function. While it was long limited to the study of the most abundant eukaryotic canonical m7G cap, the fi...
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RT @IOCBPrague: A fully-funded #postdoc position is open in @hocekm lab for a project focused on the chemical and enzymatic synthesis of ba….
uochb.cz
A fully-funded postdoctoral position in the Research Group Bioorganic and Medicinal Chemistry of Nucleic Acids (headed by Prof. Michal Hocek) for an initial period of one year (with possibility to…
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