Richard Neher
@richardneher
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i am a biologist/physicist at the @biozentrum in Basel trying to understand how microbes evolve. I am rarely here -- find me at: @[email protected]
Basel, Switzerland
Joined August 2012
Ever wondered how fast accessory genome dynamics of bacteria really is?. In a new preprint we (@mrcmolari, Liam Shaw) explore how rapidly E coli picks up genes horizontally, breaks genome synteny, etc. For a thread by Marco see .
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If you are interested in phylogeography and its limitations, have a look at my new preprint: . I also made a short thread over on
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We at the Biozentrum in Basel are launching a new MSc program in Physics of Life! Three semester of exciting courses and research. Apply by April 30 for this fall semester. And we also have a few fellowships!.
NEW: MSc in Physics of Life – training in cutting-edge research at the interface of physics, mathematics, engineering and life sciences. Apply now and be one of the first students of the program. Scholarships available. @biozentrum @UniBasel_en
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If you are an advanced PhD Student or postdoc interested in quantitative approaches to horizontal processes in bacterial evolution (exp. and theory), don't miss this opportunity!. Application deadline March 24!.
PhD students + postdocs: apply to 2024 #kitpqbio summer course, Mobile Elements in #MicrobialEvolution, at Deadline ext. to March 24. Course directors @benjaminhgood @HonourMcCann @PaulTurnerLab @jemersonmicro @richardneher #microbialecology
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I put together a short thread on our recent preprint on eco-evolutionary dynamics of RNA viruses and their hosts immune systems:.
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RT @KITP_UCSB: PhD students and postdocs: apply to the 2024 #kitpqbio summer course, Mobile Elements in #MicrobialEvolution, at https://t.c….
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Most of the credit for this part of the analysis goes to @CorneliusRoemer!.
@richardneher did an analysis of where this variant may have come from. As you can see, BA.2.86 most closely resembles the sequences circulating in Southern Africa in early 2022. It then evolves but does not spread for over a year.
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Quick reminder:. Tomorrow (Jan 3rd) is the abstract submission deadline for the 30th Viral dynamics and Evolution meeting. This year's meeting will be in Heidelberg in April!.
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RT @yunlong_cao: Our paper regarding Omicron convergent evolution is out on @Nature. In this story, we analyzed the immune evasion capabili….
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too bad this study wasn't posted on a preprint server -- the community would have had an opportunity to discuss the data and give feedback to the authors before it ends up in final form in a journal. 5/5.
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The authors report a lot of interesting data and most of these data are consistent with the canonical picture of Omicron's spread. But the putative intermediates don't support the surprising claim of gradual evolution. 4/n.
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Two of these sequences for example have mutation A23604G (P681R in Spike) that is characteristic of Delta -- a variant that dominated in August 2021. There are more such examples. 3/n.
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The putative intermediates from Benin (BEN-1 to BEN-5) are low coverage and contain signature mutations of Delta and Omicron. Contamination is thus a more likely explanation of these unexpected sequences. 2/n.
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This recent paper by Fischer et al . claims that Omicron evolved in a step wise manner with circulating intermediates. I am not convinced.
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This was a fun project with 🐘jbloom_lab@mstdn.science ! See Jesse's thread for a summary!.
In new study, we examine evolution of #SARSCoV2 mutation spectrum. TLDR: There have been changes in relative rates of mutations during SARSCoV2’s evolution, & mutation spectrum is becoming more similar to other sarbecoviruses. Thread below.
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RT @jbloom_lab: In new study, we examine evolution of #SARSCoV2 mutation spectrum. TLDR: There have been changes i….
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Thank you very much @AHRI_News @sigallab for inviting me to this fantastic workshop with exciting science in beautiful St. Lucia!.
The 1st 🇿🇦 Workshop on SARS-CoV-2 Variants & Evolution #SACovidWorkshop22 kicks off today. 84 leaders in SARS-CoV-2 immunology, virology, epidemiology, evolution & vaccines from over 30 universities & institutes are gathering to share the latest advances in #Covid19 research.
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RT @jbloom_lab: I've written an essay with my views on how to balance risks & benefits in virology research: Impor….
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