Dr Richard Hirschson
@richardhirschs1
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Physician, Intensive Care, pandemics, economics, libertarian, gambler. No financial/medical advice here. #gold #stagflation #H5N1 #MPOX .
Sydney, New South Wales
Joined January 2018
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This confirms
#MPOX
1b is a huge problem:
✴️Airborne and droplet spread.
✴️Nosocomial (hospital ) spread.
✴️Children particularly susceptible.
✴️We are not prepared for what is coming.
@RickABright
@cbarbermd
@DrEricDing
@CDCDirector
@devisridhar
@danibeckman
@drmikeryan
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@EM_RESUS
3 further observations of critical patients of mine that are about to code:
1. Their upper eyelid retracts (Muller’s muscle) due to the adrenalin surge. U see the white’s of their eyes, literally.
2. They often become incontinent .
3. Their skin becomes mottled, especially in
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@1goodtern
We are seeing a very bad
#flu
and
#Covid
season in Australia. Far more viral infections are landing up on ventilators.
I haven’t seen so many young Flu A patients on ventilator’s since 2011 (H1N1).
One of the hospitals I work at in Sydney has reached full capacity, with
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@EM_RESUS
This is the reason London telephone boxes (the red ones with the windows) were banned . They were death traps because the elderly fainted inside from the heat, and then were prevented from falling to the ground because of the 4 walls. Every morning there were a few elderly dead
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#H5N1
virus from the Texan human case in ferrets:
✴️caused 100% fatality in exposed ferret’s.
✴️Spread efficiently between ferrets by direct contact.
✴️No evidence of respiratory droplet spread (like seasonal flu).
#pandemic
#birdflu
@RickABright
@EricTopol
@mtosterholm
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@MichaelAArouet
And having 4 kids and living off welfare makes u ‘rich’.
The
#inflation
that comes together with this policy will make everyone poor.
@MichaelAArouet
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@DaniBeckman
It’s actually worse than that.
PB2 M631L is in cattle, birds, and now a human. PB E627K mutation was found in the Texas case, but he was M631L negative, which means there are other cattle lineages we haven’t fully sequenced, and don’t know the prevalence of.
The combination of
@CoronaHeadsUp
@CDCFlu
3/3 The
#H5N1
sequence from the TX human case having PB2 E627K but not M631L is notable b/c it means there’s likely a branch of the cattle outbreak that we don’t have any sequences from.
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Very important
#H5N1
trial from
@USDA
#H5N1
is spread between cattle by both the
#respiratory
and
#mammary
route.
A 🧵
@FluTrackers
@RickABright
@EricTopol
@HHSgov
@mtosterholm
@cbarbermd
@ameshaa
@jeromeadamsmd
@DrEricDing
@PeterHotez
@VirusesImmunity
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Very concerning for
#H5N1
spread either :
✴️H2H.
✴️Milk to human.
✴️Meat to human.
Big implications for all.
We need PB2 sequencing, contact virology and serology, and food testing urgently.
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@1goodtern
Thank u
@1goodtern
for this excellent thread.👏👏
✴️I’ve diagnosed 2 cases so far this year, both associated with haematological malignancies, and their treatment.
#immunosuppression
associated with these malignancies is usually when the
#JC
virus reactivates in the developed
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#H5N1
on the march.
#BREAKING
The Missouri human case is extremely troubling.
If
@DrJeanneM
is correct and the virus is ‘almost certainly’ the cattle clade, and that the patient had zero contact with livestock there are only 2 possibles:
✴️Missouri has undiagnosed cattle
At meeting this week,
@NIAIDNews
's
@DrJeanneM
said of recent bird flu case in Missouri:
- "quite nervous" about case
- "predisposition to pulmonary infection"
- no contact to anything "remotely" tied to H5N1
-
@CDCgov
can't sequence much because high CT
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@TicTocTick
The
#FED
has no control over the yield curve any longer. Market forces now control this. If they cut the short end, then the long end will spike.
The FED is now irrelevant.
#rates
will go up.
Bond cycles are generational cycles.
#depression
#hyperinflation
#hyperstagflation
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#Mpox
on the move.
✴️My ISID (International Society of Infectious Diseases) alert emails are coming in rapidly today.
✴️Malawi, Gabon, Nigeria, Kenya, Tanzania Mpox alerts have all been sent to my inbox within the last hour.
✴️The below description of a case in Uganda is
This is an alarming development in possible mpox, in Uganda, right next to Kenya.
Everyone who came into contact with his body subsequently got sick.
Location
Src
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@leadlagreport
We were always going to have a credit event or a hyperinflation. 🎯🎯
It’s the timing that is unknown.
Beats me
@leadlagreport
‘There is no means of avoiding the final collapse of a boom brought about by credit expansion. The alternative is only whether the crisis should come
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#BREAKING
#H5N1
lighting up is US wastewater.
Excellent article in
@NEJM
by
@MikeTisza
✴️ ‘The widespread detection of influenza A(H5N1) virus in wastewater from 10 U.S. cities is troubling.’
✴️’Although the exact origin of the signal is currently unknown, the lack of
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Global experts sound alarm on
#H5N1
#pandemic
potential.
@RickABright
@JesseGoodmanMD
👏👏
“The time for decisive action is not when a pandemic strikes, but today, while we have the opportunity.”
“We need voluntary vaccination, improved vaccine stockpiles, and global
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@jrdblades
@RickABright
@cbarbermd
@DrEricDing
@CDCDirector
@devisridhar
@DaniBeckman
@DrMikeRyan
Are u familiar with the Darwin Awards?
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@RageSheen
These are the tests I do on my patients with similar symptoms:
I’m seeing lots of
#Mycoplasma
at present, in addition to the viral causes. She obviously needs a CXR, WCC, CRP to exclude a bacterial pneumonia. If all negative I look at the sinuses. Hope that helps
@RageSheen
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5
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This may well be the day
#silver
closes above $30 on a daily and weekly basis.
The
#shorts
must be getting scared.
As
@TaviCosta
points out, triple tops don’t exist in metals.
This may be the beginning of an epic bull market. 🚀🚀
Now we get to see how much physical is
☆☆New high, silver closed price on SFE since its opening of 2012. New low, silver vaults on SFE since 2020. May 17, the market data on SGE/SFE.
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Yup
@AbraarKaran
.
And
#H5N1
has the ability to re-assort with seasonal
#H3N2
, and produce a reassortment virus that is fatal in mice (2010 study-
@yoshihirokawaokaand
)
The fact that this patient only had eye symptoms and otherwise mild is not the main point of concern.
The issue is ongoing spillover from animals to humans + human flu season getting nearer. Viral reassortment is the major issue given increasing risk of coinfection
#H5N1
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@I_Am_JohnCullen
This is not poultry John. This will be a human pandemic. More US servicemen lost their lives in 2018 than did from the entirety of WW1 from the Spanish flu. I don’t scare easily, but antigenic shift
Flu scares me. It goes for the young and healthy.
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#BREAKING
This is how
#Mpox
travel restrictions start.
✴️China-border checks
✴️Nigeria -border screening
✴️Fiji -below
✴️South Korea (quarantine)
✴️Many countries will follow with mandatory quarantines for passengers from hotspots.
✴️The world will shut down again, only slower
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#H5N1
is mutating rapidly towards the next human
#pandemic
.
US cattle clade sequences are now positive for these PB2 adaptions that will allow efficient spread amongst humans.
✴️E627K
✴️Q591R/K
✴️D701N
✴️M631L
It’s a complex evolution, and the interactions of the various
With our new paper just out thought I'd write a brief thread about one of the ways avian influenza virus ('bird flu') adapts to mammals (with a focus on the polymerase).
Will aim to start off simple then get into the weeds!
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@zerohedge
Watch total
#tax
take drop as the wealthy flee France’s 90% tax rate( at least their assets will).
This will be good for Lichtenstein, Singapore, jersey islands , and Bahamas .
This is not the first time France’s top marginal tax rate has been 90% .🤷♂️
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@DrEricDing
Thankfully we would know if there was efficient H2H spread as we would be seeing many cases in Australia right now. We have not found any other cases of H5N1 (human or animal) in Australia to date, though we are not looking very hard( no wastewater analysis).
@Globalbiosec
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12
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Birdflu pandemic alert:
✴️3 poultry workers in Colorado (culling chickens on the same farm) have tested positive for
#H5N1
. Other workers are also symptomatic, but testing not back.
✴️They all had
#conjunctivitis
and
#respiratory
symptoms . The combination is of huge concern.
BREAKING: Colorado reports 3 human cases of H5N1 bird flu in poultry workers
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@AbraarKaran
Yup. The next pandemic is here.
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A
#H5N1
human pandemic is inevitable, and possibly imminent.
A very important paper on Pathogenicity and transmissibility of bovine H5N1 influenza virus. (Yoshittiro Kawaoka et al , worldwide initiative,CDC)
@FluTrackers
@RickABright
@EricTopol
@HHSgov
@mtosterholm
@cbarbermd
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@StreetCred2017
It’s here. Domestic cats, dogs. Cattle. Birds. Humans. There is no avoiding it.
100 times worse than COVID has arrived . We need to vaccinate urgently. Animals fist, then humans. We really can’t wait/watch much longer.
#pandrmic
#birdflu
#massvaccination
#xofluza
#persmivir
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#BREAKING
#flu
#vaccination
#H5N1
The Holy Grail of flu prevention has proven successful in animal testing.
A Universal Flu Vaccine is to be trialled in humans soon (
#COBRA
)
This will prevent both seasonal influenza, and pandemic influenza (birdflu).
✴️Intranasal
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#BREAKING
✴️
#Mpox
death in Côte d'Ivoire.
✴️This is the first death from 1b in the country.
✴️ "28 confirmed cases, including one death" in Abidjan,
according to Dr. Daouda Coulibaly.
✴️Presumably 1b, although they don’t specifically say
#pandemic
#Mpox2024
@RickABright
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#BREAKING
#Pandemic
#H5N1
✴️
#Birdflu
is at unprecedented levels in Texan wastewater.
✴️The virus is progressively adapting to its new mammalian hosts.
✴️Could humans be next?
@RickABright
@florian_krammer
@Globalbiosec
@Mike_Honey_
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20
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#H5N1
continue to spread in US cattle.
✴️This is a slow motion train wreck.
✴️We need more up to date sequencing.
✴️We need cattle/poultry worker
#vaccinations
.
✴️We seem to be documenting history, rather than attempting to change it.🤷♂️🤷♂️
#birdflu
#pandemic
@RickABright
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@Globalbiosec
Time we started looking for
#H5N1
in our wastewater don’t u think prof??
@Globalbiosec
@DuckSwabber
@CSIRO
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#gold
moonshot in China trading today.
#shortsqueeze
likely in US and London this week. 🔥🔥
$2300 gold, the
#miners
and
#silver
are in play.🚀🚀
We are about to witness what happens when physical buying trumps paper selling.
And for the first time we might get to see what
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Worldwide
#gold
revaluation and
#remonetisation
is happening now, and it is planned.🚀🚀
🚨Gold was elevated to a tier 1 asset in BASEL 3.
🚨Central banks have been accumulating unprecedented amounts of physical gold and storing it locally.
🚨 Why else would European central
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14
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@DarioCpx
The heads of those 4 banks were in Shanghai last month . Scribes I trust think that this was a plea for physical
#silver
.
@MilesFranklinCo
did an excellent presentation on this yesterday as did
@TFMetals
a few days back. Silver can leave China,
#gold
can’t. Could they have paid
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@DrCameronMurray
Ask your local restaurateur how bussiness is. My friends that own restaurants in the eastern suburbs of Sydney say things are dire, customers are down, costs are up.
Restaurants are a pretty good gage on discretionary spending.
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@goldseek
Scary indeed. Only 2 possible causes. 1 includes War.🔥🔥
@JamesGRickards
@LukeGromen
@LawrenceLepard
@TFMetals
Worldwide
#gold
revaluation and
#remonetisation
is happening now, and it is planned.🚀🚀
🚨Gold was elevated to a tier 1 asset in BASEL 3.
🚨Central banks have been accumulating unprecedented amounts of physical gold and storing it locally.
🚨 Why else would European central
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It’s good to have top people like
@DrTomFrieden
@RickABright
@florian_krammer
@mtosterholm
, and many others working on
#H5N1
.
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15
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@DrIanWeissman
#H5N1
has been a pandemic in birds for decades.
It has been a pandemic in more than 20 mammalian species for years.
It has been a pandemic in human food sources for this year (Cattle, poultry).
There have been 14 spillover events of the current cattle virus into humans this
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8
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If I’m reading this correctly then
#H5N1
now has acquired further important
#mutations
that make it more likely to adapt to H2H spread. Thus far US cattle and human cases have had one or the other of the following PB2 mutations.
Now South Dakota cattle have both.🤷♂️🤷♂️
PB2:
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This is likely the first case of
#H5N1
food poisoning . The other option (H2H spread is far worse).
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5/
Summary:
✴️
#H5N1
spreads between cows via both the milking equipment , and the respiratory route.
✴️H5N1 has now acquired the mutations necessary to result in airborne spread between cattle.
✴️The cattle with respiratory infection are often asymptomatic, so would be silent
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#silver
and
#gold
#shortsqueeze
.
Both metals are skyrocketing on Good Friday in China.
Both spot and futures.
🔥🔥
#silversqueeze
#goldsqueeze
@WallStreetSilv
@silverguru22
@TFMetals
@FinanceLancelot
@RafiFarber
@PeterSchiff
SGEand SFE gold continued to boom after opening today. Currently, SGE gold is ￥525.08/g =$2260.40/oz, and SFE gold is ￥527.08/g=$2265.93/oz. Meanwhile, silver surged.
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Well said
@RickABright
👏👏.
There is little concern, or leadership at the highest levels
@CDCFlu
@USDAFoodSafety
@WHO
@CDCDirector
.
✴️We need full genomic sequencing of all mammalian cases of
#H5N1
shortly after diagnosis.
✴️We need to expand testing dramatically.
✴️Without
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#H5N1
has not gone away:
✴️California reports possible bird flu outbreaks in 3 dairy herds.
✴️Bird flu outbreaks in dairy herds likely underreported due to limited testing
✴️ ‘In unpublished research…the virus is detectable 14 to 16 days before farms saw a significant
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#BREAKING
#UNICEF
today announced that it has issued an emergency tender for the procurement of
#mpox
vaccines.
#pandemic
#vaccination
@RickABright
@ScottGottliebMD
@Globalbiosec
✴️UNICEF is the world’s largest vaccine buyer (2 billion vaccine doses annually).
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#MPOX
has not gone away.
✴️MPOX has now spread to 23 of 26 provinces in the DRC.
✴️The disease is spreading through various contact forms, including sexual, nonsexual, household, and healthcare.
✴️Clade 1b predominantly affects kids( 39% of cases).
✴️Mortality is 5%.
🧐Clade 1b
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@6NewsAU
Ridiculous that no one in the infectious diseases community like myself knew anything about this until now. No internal medical channels were activated to the best of my knowledge. Did the patient fly through Sydney, where I work at one of the major hospitals admitting infectious
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@LazarusLong13
Historical data on Orthopoxviruses confirm airborne routes of transmission ( they are respiratory viruses). There is no data suggesting clade 1b is any different .
There is a difference between ‘airborne droplets’ and ‘aerosolised’… but both cause airborne spread. The DRC RO
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There is no doubt in my mind that
#Pox
vaccinations will once again become part of the routine childhood vaccination program, as it was prior to 1972.
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@MarioNawfal
#H5N1
will be the biggest story of the 2020’s.
Notable scientists have been banging the table (
@RickABright
@DrTomFrieden
@mtosterholm
)
Please continue to cover this
@MarioNawfal
🙏🙏.
It may well be the
#pandemic
that restores credibility in the medical system.🤷♂️🤷♂️
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16
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Complicated thread on the human case of
#H5N1
from Missouri.
Take-aways.
✴️This virus has previously only been found in 1 cattle herd from Texas.
✴️This virus has adaptions that allow it to bind to human throat receptors (a2,6 SA).
This is the first case of
#flu
food
Here is analysis of HA mutations in H5 influenza case in Missouri resident without known contact w animals or raw milk.
TLDR: there is one HA mutation that strongly affects antigenicity, and another that merits some further study.
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Airborne infected cows:
Respiratory disease was mild in the heifers, but infection was confirmed by replicating virus detection in the airways and lungs , as well as seroconversion. Thus asymptomatic cows are able to spread H5N1 to the rest of the herd.
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#BREAKING
#Mpox
1b alert in Thailand.
#pandemic
#Mpox2024
✴️Symptomatic patient flew from DRC, via Middle East, to Thailand 14/8.
✴️This is Clade 1b (Clade 2 excluded by testing).
✴️International spread has started (Sweden, Thailand).
✴️African spread continues.
It has not yet been definitively determined whether a foreign national who traveled from the Democratic Republic of the Congo is infected with the new mpox Clade 1b strain, said Dr. Thongchai Keeratihattayakorn, Director-General of the Department of Disease Control (DDC).
Dr.
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Chinese Gold revaluation this year?
The unfolding collapse of the Chinese property/stock markets,and associated deflation, will force the CCB to revalue gold .Watch the metal trade in Shanghai.
#GOLD
@DarioCpx
@TaviCosta
@LukeGromen
@GoldTelegraph_
@goldseek
@GoldSwitzerland
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6
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First case of lethal human
#H5N2
reported from Mexico.
No exposure to birds.
Could this be a reassortment virus from
#H3N2
that is already circulating seasonally in the human population, and
#H5N1
?🤷♂️🤷♂️
Very worrying. Thankfully no close contact contagion.
Thank u
@DrEricDing
NEW—The WHO & Mexico reports world’s first-ever human case & death from H5N2 bird flu (another bird flu type, not the H5N1 that’s more active lately). 59-year-old died in Mexico City and had **ZERO** exposure contact with any poultry or other animals. Close contacts negative too.
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@adamjkucharski
I agree
@adamjkucharski
.
The
#CDC
maintains that
#H5N1
is a low risk for humanity. The
#WHO
has neither declared a PHEIC or a Pandemic Emergency. With this degree of apathy , national health authorities are in limbo.
Quarantine policies won’t work.
Only pre-emotive
#vaccination
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@MarioNawfal
Seems silly. Hope he gets to go for a swim.
A victory for free speech , and freedom of expression.
@JulianAssange_
you will be welcomed home in Australia as a hero.
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@DaniBeckman
It’s actually worse than that.
PB2 M631L is in cattle, birds, and now a human. PB E627K mutation was found in the Texas case, but he was M631L negative, which means there are other cattle lineages we haven’t fully sequenced, and don’t know the prevalence of.
The combination of
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✴️ U.S. Agriculture Secretary
@SecVilsack
authorises the first trial of an
#H5N1
#vaccine
for cattle.
✴️Unsure which vaccine is being trialed ( Ceva and Medgene are contenders).
✴️’A vaccination strategy could be critical in curbing disease spread but could be difficult to
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@DrTedros
@WHO
@AfricaCDC
Thank u
@DrTedros
.
We need leadership from the top.
We’ve controlled/eradicated a POX virus before, no reason why we can’t do it again.
We have the science, we just need to deploy the resources.
#WHO
#MPOX
@RickABright
@JeremyFarrar
@CDCDirector
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Disease in lactating cows was significant, as previously reported . Infection was confirmed by high levels of viral RNA detected in milk, virus isolation, lesions in mammary tissue, and seroconversion. Viral persistence was evident at 24 days post inoculation.
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✴️My opinion: If pandemic flu does arrive, we will save many lives if every Australian has a 20 mg tablet of Baloxavir on hand (or Tamiflu course as a minimum). The cost will be negligible compared to the only other option, lockdowns.
✴️But to stand any chance we need urgent
0
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