RESAT CINAR
@resatcinar
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Scientist, pharmacist, pharmacologist, researching on cannabinoids, endocannabinoids, and pulmonary fibrosis. fibrosis researcher. —opinions are my own views.
Maryland, USA
Joined July 2012
🧵7️⃣.Our research exemplifies amazing team and collaborative effort (@m_konigshoff lab)! Big shout out to @abhishekbasu86 @muharif . #antifibrotic #TherapeuticDiscovery #DrugDiscovery #PulmonaryFibrosis #CurePF #CureHPS .#CB1R.
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🧵6️⃣ . 📌 #Zevaquenabant treatment effectively reduces #fibrosis in human precision-cut lung slices (#hPCLS). 📌 Pulmonary delivery of zevaquenabant may offer a more targeted and safer #therapeutic modality for #fibrotic #lung #diseases.
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🧵5️⃣ ⚡️Therapeutic modality to improve antifibrotic efficacy⚡️. 📌Systems #pharmacology reveals that #zevaquenabant and #nintedanib treatments reverse distinct and shared #pulmonaryfibrosis related pathways, provides opportunity for future clinical trials to improve the efficacy.
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🧵4️⃣ ⚡️Therapeutic modality to improve antifibrotic efficacy⚡️. 📌 #Zevaquenabant attenuates multiple #fibrosis-related pathways in lungs. 📌 Pulmonary delivery of zevaquenabant attenuated #fibrotic #macrophages expressing Spp1, Trem2, Tgfb1, Mertk, Fabp5, Cd9, Cd63, Gpnmb, Fabp4.
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🧵3️⃣ ⚡️Therapeutic modality to improve safety ⚡️. 📌🫁Pulmonary delivery of #zevaquenabant (#MRI1867) by lowering the systemic dose 20-fold retains superior therapeutic efficacy in mitigating PF by eliminating systemic exposure in animal model of #PulmonaryFibrosis.
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🧵2️⃣ ⚡️Therapeutic target identification⚡️. 📌 CB1R regulates #CD206-expressing macrophages and releases of #profibrotic mediators (IL-6, IL-4, LIF, GM-CSF, CXCL10, CCL7, CCL11, IGF-1). 📌 Inhibition of CB1R in AlveolarMacrophages attenuates #fibrogenic activation of Macrophages.
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🧵1️⃣ ⚡️Therapeutic target identification ⚡️ . 📌 CB1R in #AlveolarMacrophages (AMs) is responsible to release #anandamide into #alveoli and to promote #fibrosis. 📌 CB1R in AMs plays a dominant role in pulmonary fibrosis by inducing fibrogenic macrophages.
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📣Our research @JCI_Insight highlights the key role of #cannabinoid receptor 1 (#CB1R) in #AlveolarMacrophages in promoting #PulmonaryFibrosis. We propose that pulmonary delivery of #zevaquanabant as an effective and safer therapeutic approach for PF.
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‼️A post-doc position available in my lab at the NIH ‼️. ⚡️Fibrosis Biology.⚡️Biomarker Discovery.⚡️Pharmacology.⚡️Therapeutic discovery.⚡️Translational research . See the position details👇. #postdoc #Fibrosis #pulmonaryfibrosis #RareDisease . Please RT.
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Our research shows anandamide in blood has biomarker functions in Hermansky-Pudlak syndrome. It not only captures early stage fibrosis progression in lung but also informs on therapeutic effect for CB1R antagonism.This may help to design effective anti-fibrotic therapy @CureHPS.
Anandamide Is a Potential Blood Biomarker of Hermansky-Pudlak Syndrome Pulmonary Fibrosis. This study suggests that circulating anandamide levels begin to increase with the fibrotic lung process even at subclinical stages.@resatcinar @IRPatNIH . 🔗
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RT @neurovoice: 📣 New Hurd Lab paper in @molpsychiatry explores how cannabidiol (#CBD) can help reduce anxiety linked to specific triggers.….
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RT @NIAAAnews: Meet Lenny Pommerolle, Ph.D., @pommerollelenny, a postdoc in NIAAA’s Section on Fibrotic Disorders, is studying the biologic….
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RT @NIAAAnews: Study by @IRPatNIH scientists in #NIAAA's intramural program sheds light on gender-specific mechanisms by which chronic alco….
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Congrats to @pommerollelenny and @ctm_dijon team for this impactful work! This work not only endorsed CD206 expressing macrophages as a profibrotic macrophages in progressive #pulmonaryfibrosis but also elegantly provides an imaging tool to use biomarker function of CD206 imaging.
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The blood biomarker functions of #Anandamide may help targeted prophylactic or early therapeutic interventions in a highly predictable fibrosing #rarelungdisease #HPSPF in the future.
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Our preprint presents #endocannabinoid #anandamide (#CB1R agonist) in blood has both early disease #biomarker and surrogate marker functions in Hermansky Pudlak syndrome pulmonary #fibrosis (#HPSPF) @HPSNetwork.
Anandamide is an Early Blood Biomarker of Hermansky-Pudlak Syndrome Pulmonary Fibrosis #medRxiv.
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19 Mayıs’ta gençler ve bilim tutkunları ile #bioinfocongress de buluşmayı heyecanla bekliyorum. Sizlerle kendi bilimsel serüvenimi ve laboratuvardan kliniğe ulaşan bir ilaç geliştirme hikayesini paylaşacağım. @bioinforange #obezite #diyabet #fibrozis #farmakoloji.
#Bioinfocongress VI kapsamında, 19 Mayıs 2024 tarihinde 16.30-17.30 saatleri arasında Sayın Dr. Reşat Çınar "Metabolik Hastalıklar için Kannabinoid Reseptörleri Hedef Alan Bir ilaç Geliştirme Hikayesi“ konulu konuşmasını gerçekleştirecektir. 🔗Kayıt linki:
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#postdoc #NIH #aespaSupernova #Drugdiscovery #fibrosis #AUD @NIAAAnews . ✨@IRPatNIH has excellent training opportunities in a highly supportive and collaborative environment.
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