Rebecca McGillivary
@rebmcg
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Interested in mechanobiology of the nucleus, microscopy, and cell morphology. Postdoc: @ucdavis, @DanStarrUCDavis & @gwgl1979. PhD: @ucsf, @WallaceUcsf
Davis, CA
Joined April 2012
RT @gwgl1979: This is so exciting! New collaborative work with old friends (Starr/Luxton and MOM Labs). Nesprin-2G….
biorxiv.org
Nesprins are integral membrane proteins that physically couple the nucleus and cytoskeleton. Nesprin-2 Giant (N2G) stands out for its extensive cytoplasmic domain, which contains tandem N-terminal...
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RT @gwgl1979: Check out @rebmcg new review on the regulation of LINC complex assembly now out @sciencedirect Current Opinion in Cell Bi….
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So glad my Stentor paper is out in its final form! Working on this project was an adventure from start to finish. Studying this wild, giant nucleus sparked my interest in nuclear shape and mechanics.
Finally out: We usually draw nuclei as being spherical, but they can have many different shapes. In her new paper, @rebmcginvestigated the mechanism of nuclear shape change, using the Stentor macronucleus as a model system.
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Update - the mystery egg was stuck to the chick this morning (not sure how??), and now it has been removed from the nest
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If any birders on science Twitter have any ideas for what is going on with this mystery egg, we'd love to hear it (4/4).
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And now today we noticed there's a new egg in the nest! Could this be a case of brood parasitism? The new egg (towards the front) looks slightly smaller and grayer, and it has a few gray speckles. (3/n)
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We've been watching this lil guy grow up quickly and got used to him trying to peck us whenever we used our BSL2 trash can near his window (2/n)
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A couple of pigeons have been building a nest next to our tissue culture room's window - today we saw their egg for the first time!
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RT @krassenstein: The attacks on Michael Cohen, Stormy Daniels and Hope Hicks will be over the top as Trump is indicted in Manhattan. Trum….
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Not your typical nuclear envelope! Congratulations, @ENieweglowska! Beautiful work 😍.
Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵. #phage #jumbophage #cryoem .
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RT @WallaceUcsf: happy to announce our paper on the transcriptional program of regeneration in Stentor! . Stentor is a giant cell with a c….
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RT @ENieweglowska: Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a singl….
biorxiv.org
A growing number of jumbo bacteriophages, with genomes exceeding 200 kb, have been found to establish a Phage Nucleus—a micron-scale, proteinaceous structure encompassing the replicating phage DNA....
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Amazing new work from my labmate @karina_perlaza! This is such a cool story 🤩.
Chlamydomonas shf1 mutant flagella grow to half length and then abruptly stop. the shf1 gene was first described in 1984 but its identity was never determined until now - check out this preprint from @karina_perlaza who shows shf1 is a TOG protein.
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Also definitely check out @PranidhiSood’s preprint as well! Her work helped spearhead this project - and there’s a lot more fascinating Stentor biology where that came from! (12/12)
biorxiv.org
The giant ciliate Stentor coeruleus is a classical model system for studying regeneration and morphogenesis at the level of a single cell. The anterior of the cell is marked by an array of cilia,...
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A huge thank you to @wallaceucsf, @PranidhiSood, Kasia Hammar, and the Marshall Lab for all of their contributions to this project and for their enthusiastic support. It was a ton of fun to work on this project with such amazing people! (11/n)
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My time working with Stentor has led me to become fascinated with the broader fields of cellular mechanics and cell biology of the nucleus. I’m so thrilled to study nuclear mechanobiology during my upcoming postdoc with @DanStarrUCDavis and @gwgl1979 at UC Davis! (10/n)
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Working on this project was an adventure – and I still have more questions than answers! How do the mechanical properties of the macronucleus change over regeneration? I hope this work can provide a molecular foothold for future studies of this amazing nuclear shape change. (9/n).
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