ALADDIN project
@projectaladdin
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ALADDIN is an #EICPathfinder project accelerating the discovery of therapeutic nanobodies for an improved treatment of #cancer. Funded by the @EU_EISMEA 🇪🇺
Joined February 2024
Oncology research is crucial in ALADDIN to... 🔎 Set up the tools for preclinical nanobody validation 🔎 Identify therapeutic targets in pancreatic & colorectal cancers @ISCIII & Instituto Investigación Sanitaria Fundación Jiménez Díaz focus on this field in the project!
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New anti-carcinoembryonic antigen nanobody CE-21 enables high-contrast PET imaging & effective radionuclide therapy in colorectal & epithelial cancers. 🔬 This gives promise for faster, safer, and more precise treatment! https://t.co/N5KoWbGISp
link.springer.com
Journal of Nanobiotechnology - Carcinoembryonic antigen (CEA) is a clinically validated biomarker and therapeutic target in colorectal and other epithelial malignancies, yet current antibody-based...
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Zebrafish modelling is one of the core elements of the ALADDIN approach! The @liu_universitet team focuses on... 🐠 Developing humanised zebrafish models 🐠 Assessing the efectiveness of selected nanobody candidates in zebrafish models #ALADDINproject #EICPathfinder @EUeic
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Research article from a team including researchers from ALADDIN partners @SaludISCIII & Instituto Investigación Sanitaria Fundación Jiménez Díaz! Tropomodulin-2 (TMOD2) could be a promising therapeutic target to combat colorectal cancer metastasis. 🧬 https://t.co/DznGRR4wUx
nature.com
British Journal of Cancer - Deciphering the central role of TMOD2 in colorectal cancer progression and metastasis
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Molecular & synthetic biology are essential in ALADDIN, including: 🔬 Nanobody selection from non-immune libraries & in vivo maturation systems 🔬 Nanobody discovery with the integrated ALADDIN platform These tasks & project coordination are carried out by the @CNB_CSIC team!
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New hope for snakebite victims 🐍 A new nanobody-based recombinant antivenom protects against cobras, mambas, and rinkhals, outperforming traditional antivenoms in animal tests. 🔗 Read more from @Nature:
nature.com
Nature - A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and...
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A nanobody-based “plug-and-display” system enables rapid development of combination vaccines. 💉 Tested against SARS-CoV-2, influenza & RSV, it showed strong protection in animals. Read the article published in @NatBME:
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All research articles published as part of the ALADDIN project, in one place! 📄 Dive into the Resources page of our website for a continuously updated repository of our project’s research papers. Discover more: https://t.co/6JuUBgVJK1
#ALADDINproject #EICPathfinder @EUeic
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Today is World Pancreatic Cancer Day, a day all about raising awareness of the risks and symptoms of this cancer. In ALADDIN, we study pancreatic cancer patients’ samples to identify therapeutic targets, contributing to the work towards improved treatments for cancer. #WPCD
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Uncovering dormancy in colorectal cancer 🧬 Colorectal cancer remains one of the most prevalent & deadly cancers worldwide, with up to 50% of patients relapsing after treatment. This study explores tumour dormancy and biomarkers to predict recurrence. https://t.co/bm66lfd31Q
pubmed.ncbi.nlm.nih.gov
Colorectal cancer (CRC) is not only the third most common cancer worldwide, with 1.1 million new cases per year; it is also the second leading cause of cancer death. However, mortality has decreased...
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ALADDIN in the spotlight 💡 Researcher Lidia Cerdán García presented our project at the "V Jornadas Científicas PTI+ Salud Global" event in Madrid, Spain. The event focused on the research conducted at our coordinating institution, the Spanish National Research Council @CSIC!
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In ALADDIN, synthetic biology works hand in hand with #AI! Using AI, structural predictions can be done to... 💻 Model how nanobodies bind to antigens 💻 Optimise and humanise nanobodies AI modelling in the project is done by @HebrewU. #ALADDINproject #EICPathfinder @EUeic
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Microfluidics form a crucial ingredient in our project approach ✅ In ALADDIN, @INLnano... 🔬Develops microfluidics devices to select nanobodies from bacteria 🔬Implement the devices into the multidisciplinary ALADDIN platform #ALADDINproject #EICPathfinder @EUeic
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It's World Science Day for Peace and Development 🌏 This day, established by @UNESCO, highlights the role of science in society. We contribute to this mission through our work in raising awareness and supporting research & innovation to achieve real impact! #WorldScienceDay
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Mathematical modelling is a key part of the ALADDIN project📈 It’s crucial for: 🔎 The identification of therapeutic targets 🔎 The preclinical validation of nanobodies in zebrafish The power of mathematics is unleashed in our project by @InCELLia! #EICPathfinder @EUeic
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Refining prognosis in pancreatic cancer 🎯 Accurate staging is vital for improving outcomes in pancreatic adenocarcinoma. A study comparing the 7th and 8th editions of the AJCC TNM staging system in 214 surgically treated patients reveals key findings. https://t.co/o7srMSXYp8
pubmed.ncbi.nlm.nih.gov
Introduction: Accurate staging is essential in pancreatic adenocarcinoma due to its aggressive nature and poor prognosis. The 8th edition of the AJCC TNM staging system introduced changes in tumor...
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ALADDIN at the XXI National Meeting of Sociedad Española de Biología Celular 🙌 Last week, PI Javier Martinez-Useros from the Instituto Investigación Sanitaria Fundación Jiménez Díaz joined the event and presented the ALADDIN project. #ALADDINproject #EICPathfinder
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Did you know? By combining omics, mathematical models, synthetic biology, AI & microfluidics, we can... 🔎 Identify novel therapeutic targets 💡 Predict which nanobodies will bind best to their targets 🙌 Validate the efficacy of the nanobodies https://t.co/PPgZGrldcx
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Pancreatic cancer is highly aggressive and often resistant to therapy. 🚫 Exosomes mediate communication in the tumour microenvironment, driving chemoresistance. Learn how targeting them could improve outcomes:
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Stay up to date on the latest ALADDIN news! 📰 Our blog is the go-to for relevant updates about the project. Discover our meeting summaries, interviews with project partners, and more: https://t.co/7dojtAoLTY
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