preLights
@preLights
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A preprint highlights service run by the biological community and supported by The Company of Biologists
Cambridge, England
Joined December 2017
🚨 Call for preLighters!🚨 Help us highlight the most exciting biological preprints. Share your insights, build your profile, and be part of a supportive community! 🌍 Interested? Apply today & help shape the future of science publishing! 📢 More info: https://t.co/SJeh69HFGU
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Helping the next generation of scientists find their voice. 📣 Discover how @SeahSamantha empowers students through her path from preLights to Executive Editor of the Journal of Emerging Investigators. Interview: https://t.co/0ysXeNwKU6
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Vitamin B12 preserves skeletal muscle mitochondrial DNA integrity and respiration, linking B12 deficiency to mtDNA uracil accumulation and impaired muscle energy metabolism. #preprint from @marthafield7 & team #preLight by Yan Aveiro dos Reis ⬇️👀 https://t.co/pEkJ2r7w3H
prelights.biologists.com
Vitamin B12 preserves skeletal muscle mitochondrial DNA integrity and respiration, linking B12 deficiency to mtDNA uracil accumulation and impaired muscle energy metabolism.
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Meet TFlex— a new tool to uncover how natural & synthetic transcription factors shape human CD8+ T cell states. #Immunology Inês Caiado highlights recent work from Riley Mullins & colleagues. #preprint
#preLight ⬇️ 👀 https://t.co/o7VifROKd9
prelights.biologists.com
Meet TFlex— a new tool to uncover how natural and synthetic transcription factors shape human CD8+ T cell states.
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A cardiomyocyte's journey to maturity ❤️ The #preprint authors, @Mengmenghuang_ & team #BurnsLab, generate a model of RBFOX2 haploinsufficiency to identify the gene’s effects on cardiomyocyte maturation. A more visual #preLight by Theodora Stougiannou⬇️ https://t.co/FA5xo7c1pN
prelights.biologists.com
A cardiomyocyte's journey to maturity: In the preprint highlighted here, the authors generate a model of RBFOX2 haploinsufficiency to identify the gene’s effects on cardiomyocyte maturation.
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Ancient Denisovan DNA from a 200,000-year-old genome & a new global map of archaic structural variants show that inherited Denisovan segments, including whole centromeres, still shape human diversity and local adaptation today. #preLight by @SidSin0809⬇️ https://t.co/wABAfT5sZo
prelights.biologists.com
Ancient Denisovan DNA from a 200,000-year-old genome and a new global map of archaic structural variants show that inherited Denisovan segments, including whole centromeres, still shape human...
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Insightful ‘postLight’ just uploaded by @Simon_J_Cleary 👀 Simon revisits work discovering structures that control megakaryocyte protrusion events: extracellular matrix cages – work reviewed and published at @eLife
#postLight:
prelights.biologists.com
The megakaryocyte: trapped in a cage of its own making
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ILC2 orchestrates the immune defense against intestinal infections through the secretion of type 2 cytokines. #immunology
@andreamorimc63 discusses preprinted work from Rita Berkachy & colleagues now published in PLOS Pathogens. #postLight
#preLight ⬇️ https://t.co/P8Trvmh38y
prelights.biologists.com
ILC2—traditionally recognized for mediating anti-parasite responses—orchestrates the immune defense against intestinal infections through the secretion of type 2 cytokines
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On post-translational modifications & their contribution to help shape human cortical development 🧠 Jawdat Sandakly (@sandaklyj) covers a recent #preprint from Julien Pigeon and colleagues @TheHassanLab. #DevBio #Neuroscience Read the #preLight ⬇️👀 https://t.co/j1Zu8kQds7
prelights.biologists.com
On post-translational modifications and their contribution to help shape human cortical development
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When gut microbes and CD4+ T cells go from chill to allergic drama queens 💥 Mitchell Sarmie teamed up with Serena Restori to highlight recent work from Alexa Weingarden & colleagues @umnmedschool. #preprint #immunology Check out the #preLight ⬇️ https://t.co/esEBXvlqe9
prelights.biologists.com
When gut microbes and CD4+ T cells go from chill to allergic drama queens
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Our next extraordinary biologist is Grace Lim, a prolific preLighter @preLights and contributor to @the_Node and @Dev_journal. #100biologists
@gracelimhuiyi
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GV101 will, GV101 will ROCK you! Collaborative #preprint from David Herrmann & team @GarvanInstitute describes the impact of a ROCK2-specific inhibitor on stromal & epithelial cells in the context of triple -ve breast cancer. #preLight by @PitkeSharvari
https://t.co/xf2be0ZIhP…
prelights.biologists.com
GV101 will, GV101 will ROCK you!
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Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis.🩸 Hannah Pletcher highlights work from Narges Pourmandi & colleagues @LyssiotisLab
#preLight⬇️ https://t.co/hCdyht8iic
prelights.biologists.com
Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis.
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When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning. 🌱 #PlantBiology Goldy & team uncover a central role for F-actin as a cortical landmark. #preLight by Jeny Jose @UmeaPlantSci ⬇️👀 https://t.co/DHGMmU3Xk0
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Hala also shares the heartbreaking, courageous story behind her own #preprint now on #medRxiv. “Every research paper carries a story... Mine begins in a small parasitology lab in Sudan, on the last day before the war forced me to flee.” Read on:
prelights.biologists.com
Every research paper carries a story—one that rarely makes it into the methods or the discussion section. Mine begins in a small parasitology lab in Sudan, on the last day before the war forced me to...
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The challenge of diagnosing Schistosoma haematobium infections in school-aged children in SW Nigeria. @hala_elbashir highlights important work underscoring the urgent need for improved diagnostics & interventions in endemic regions. #preprint
#preLight⬇️ https://t.co/GPq5HCho1e
prelights.biologists.com
Schistosoma haematobium DNA & eggs detected in urine of school-aged children in SW Nigeria. Findings underscore the urgent need for improved diagnostics & interventions in endemic regions.
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Battling the TB blues...😷 A pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala & colleagues @IMI_ERA4TB to characterise the activity of TBAJ-587 and its metabolites. #preprint #pharmacology Latest #preLight from @goh_zhanghe ⬇️👀 https://t.co/T0g69CP435
prelights.biologists.com
Battling the TB blues: a pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala and colleagues to characterise the activity of TBAJ-587 and its metabolites
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1/5 🚨🚨 preprint alert! 🚨🚨 I wish to introduce CARDIB, not the singer, but the protein. CARDIB=CARD Inhibitory Binding protein. In our new work we discover this protein that is found in all Anthozoa (sea anemones and corals 🪸) but not in other animals. https://t.co/9yYZ3ARZvI
biorxiv.org
How antiviral immunity first arose in animals is a central question in evolutionary biology. Using the sea anemone Nematostella vectensis , we identify CARDIB , a previously uncharacterized gene...
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Exposing hydrophilic residues pushes misfolded ER proteins towards degradation. 🗑️ Ana Sanchez-Molina: “…this study reshapes our understanding of protein quality control…” #preprint from @rudypisa & Tom A. Rapoport #HarvardMed
#preLight ⬇️ 👀 https://t.co/LmXsdzcWq3
prelights.biologists.com
Exposing hydrophilic residues pushes misfolded ER proteins towards degradation.
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How an immature glymphatic system fails to suppress Zika virus infection in the brain 🧠 @JimengLi1021 highlights work from Jhulimar Guilherme Doerl & colleagues @ufrnbr #preprint Check out the #preLight! ⬇️ 👀 https://t.co/IfBspACCvY
prelights.biologists.com
The necessary wait – How an immature glymphatic system fails to suppress Zika virus infection in the brain
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On how Vangl2 shapes the heart ❤️ Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism. #preprint from the team of Sigolène Meilhac. #preLight from Anubhav Prakash @appy_anubhav ⬇️👀 https://t.co/R4NWa1tYpU
prelights.biologists.com
Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism.
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