If you are a single guy, this may be the most valuable podcast of the year for you. Blaine Anderson (the #1 dating coach for men) explains how to feel more confident dating + attract awesome girlfriends:. (🧵)

The Epstein List is The Ring

3% inflation is insane as a target. Bessent is generally cool, but a 50% increase in inflation forever is a nightmare. 3-2-3, not 3-3-3 plan….

Highly recommend Tuttle Twins for kids and Angel. Not perfect, but lots of great and fun lessons. H/t to @JMilei

RT @ParanoidPol: Cooper’s dislike of Churchill doesn’t stem from his actions during WWII. We cover this in the episode of @crackpothist I….

RT @podcastnotes: There's no magic cure for depression. But there are some things that actually help when you feel like you're drowning.….

RT @podcastnotes: 4/ The inflammation factor:. Chronic stress triggers brain inflammation. Instead of producing serotonin from tryptophan,….

RT @JoshuaSteinman: Dear friends. Once again, we find ourselves at decisive point. Moneyed interests are trying to slip a dangerous anti-A….

Startups and biotech rejoice. Your losses count as losses again.

RT @podcastnotes: 5/ EPA omega-3 fatty acids (1000mg+). Clinical studies show EPA specifically reduces brain inflammation and improves depr….

All of this comes from @hubermanlab latest ESSENTIALS episode "Understanding & Conquering Depression" 👉 He breaks down the actual biology behind depression and gives you the real science, not just "think positive" nonsense. Worth listening to the full.

10/ Depression has real biological causes and real biological solutions. You're not weak or lazy. Your brain chemistry is disrupted. Start with basics: sleep, omega-3s, professional help when possible. The goal isn't perfection, it's progress. Hope this helps someone today.

9/ Emerging treatments showing promise:. • Ketamine therapy for treatment-resistant cases. • Psilocybin in clinical trials with 60-70% response rates. • Ketogenic diet for some people who don't respond to medications. These aren't mainstream yet, but the research is.

8/ Sleep and cortisol timing. Depression often disrupts your cortisol rhythm. It should peak in the morning, not at night. Morning light exposure, consistent sleep times, and avoiding screens before bed can help reset this cycle. Simple but surprisingly effective.

7/ Cold exposure (when you can manage it). Brief cold exposure naturally increases norepinephrine, which can help with energy and focus. Start small: 30 seconds of cold water at the end of a shower. Not a cure, but a tool that works through known biological pathways.

6/ Creatine supplementation (3-5g daily). Originally studied for muscles, now showing promise for brain energy metabolism. Some studies suggest it can enhance antidepressant effectiveness or help on its own. Inexpensive and well-researched for safety.

5/ EPA omega-3 fatty acids (1000mg+). Clinical studies show EPA specifically reduces brain inflammation and improves depression symptoms. It's not magic, it's targeting the same inflammatory pathways that contribute to the condition. Easy to start, works alongside other.

4/ The inflammation factor:. Chronic stress triggers brain inflammation. Instead of producing serotonin from tryptophan, your inflamed brain creates a toxic byproduct. This explains why depression feels so physical and why anti-inflammatory approaches can help.

3/ SSRIs help about 60-70% of people, but they're not perfect. They don't increase serotonin production. They just help existing serotonin stay active longer. This is why they can take 2-6 weeks to work, and why they don't work for everyone.

2/ The three key brain chemicals:. • Norepinephrine = energy and alertness. • Dopamine = motivation and pleasure. • Serotonin = mood regulation and sleep. In depression, these systems malfunction. That's why "just think positive" doesn't work.

1/ Depression isn't just sadness. It's a biological state where:. • You wake up at 3-4 AM and can't fall back asleep. • You lose the ability to feel pleasure (anhedonia). • Your brain creates negative thoughts that feel completely real. • Basic tasks become overwhelming. Your.