CAR-T cell therapy can be great, but. the T cells express PD1 and get exhausted. Check out this #GIF I made for a recent @jitcancer paper on this topic (.___.#cancer #immunotherapy #AcademicChatter #AcademicTwitter #scicomm (credit: @Biorender)

Just like people, T cells get exhausted. Taking a break helps!. Here, the authors developed a SNIP CAR - “a protease-based platform for regulating CAR activity using an FDA-approved small molecule”, which showed diminished T cell exhaustion #Immunotherapy

How can regulatory T cells (Tregs) be depleted in cancer?. In this recent paper in @ScienceTM, the authors show how dual targeting of CTLA4 and CD47 on Tregs is effective. #AcademicTwitter #Immunotherapy @UTSWNews

What’s happening with CAR-T cells and beyond in cancer?. This nice review summarizes recent advances and efforts to leverage T cells and NK cells. . #Immunotherapy #AcademicTwitter

Can pre-treatment with targeted therapy influence response to subsequent immunotherapy?. Here, they show that "when tumors relapse after anti-MAPK targeted therapy, they are cross-resistant to immunotherapies". #Immunotherapy @NatureCancer

Can immunotherapy provide long-term responses?. Median survival (months) for metastatic melanoma was reported at ASCO for:.CTLA4 + PD1 👉 72.1 .PD1 👉 36.9.CTLA4 👉 19.9. #AcademicTwitter #cancer #Immunotherapy @ASCOPost .

Predicting response to immunotherapy is important, but what’s a good marker?. Here they show how TCR clonality of tumor-infiltrating T cells predict anti-PD1 efficacy: #AcademicTwitter #cancer #immunotherapy @NatureComms

Does tumor location/tissue site matter?. Here they show how the same tumor cell line display different take rates, immune infiltration, and response to immunotherapy depending on where the tumor grows. #AcademicTwitter #cancer #Immunotherapy @CIR_AACR

How do tumor cells survive in the circulation?. This recent paper highlights the importance of CCL5 as a mediator of immune evasion. #AcademicTwitter #cancer @NatureComms

When to give immunotherapy?. Giving anti-CTLA4 BEFORE anti-PD1 was found to be superior in this recent paper: . #AcademicTwitter #Immunotherapy @NatImmunol @ljiresearch

#cancer #Immunotherapy.

Who will respond to immunotherapy?. This recent paper suggests that the tumor microenvironment falls into 4 categories and can predict therapeutic response: #AcademicTwitter @MDAndersonNews @BostonGeneCorp

Cool new finding and beautiful images when researchers identify "a link between sensory neurons activation and the immune system". #AcademicTwitter #phdchat .

RT @ndemenez: Send a picture of something that shows very clearly you are a Grad/Undergrad student! This is mine 🤣 . #phdchat @AcademicChat….

Repurposing of drugs for cancer is already a popular strategy. Should all drugs, within reason, that have passed toxicity studies in any indication, be tested in preclinical models of cancer in a high-throughput manner? #AcademicTwitter.

Just me having too much fun editing this video! Tell me more about you #phdchat #phdlife #postdoc #academictwitter

RT @OpenAcademics: Let me know if you have entered this graphical abstract contest at @BioRender - I would love to share yours❤️.#AcademicT….

It really hits me hard seeing young people die in cancer. Moments of feeling hopeless is exchanged with motivation. Motivation to do better, to contribute to better therapies. What's your motivation? #AcademicTwitter #cancer #phdchat #beatcancer.

Making friends with scorpions? 🦂 . Enter this competition at @BioRender or just vote for my contribution 😃 #AcademicTwitter #sciencetwitter #phdchat #scicomm #cancer #Immunity #scicomm. Link:

Enter this competition at @BioRender or just vote for my contribution😀 #AcademicTwitter #sciencetwitter #phdchat #scicomm #cancer #Immunity #angiogenesis . Link:

Enter this competition at @BioRender or just vote for my contribution😍 #AcademicTwitter #sciencetwitter #phdchat #covid #corona #Covid_19 #scicomm #openscience .