1. PSEUDOGOBLET CELLS. Continuous and linear pattern and lack the strong blue staining of acid mucin when stained with alcian blue. 2. TRUE GLOBET CELLS. Singly dispersed, pale gray on H&E, and due to acid mucin they turn intense blue with alcian blue stain. #GIpath

While causes of IBS are unknown, they found a positive feedback loop where 5-HT7 plays a key role. This may lead to a promising treatment using 5-HT7 antagonist which would improve the quality of life for millions of sufferers. So checkout the latest and greatest in this paper!

IBS is often diagnosed. Pain from hypersensitivity is the worst part for patients. In this paper they investigated the role of 5-HT7 receptors in mucosal innervation and intestinal hyperalgesia.

Colonic biopsies due to chronic pain are very common in Pathology labs. Chang et al describe mechanisms of hypernociception from IBD in this awesome paper: https://t.co/Rsb2PBrZdq A must read! @DCF_path #GIpath #IBD

▪️Piet Mondrian Mondrian is known for his straight lines and pure colors, orderly and mathematical. However, some of his early works with serene landscapes reminds us of the diverse structures of neurons in the central nervous system #pathart #pathtwitter #pathology #pathologist

▪️Jackson Pollock Perhaps the greatest figure in the abstract expressionist movement. His "drip technique" is reminiscent of loose connective tissue that is stained with charcoal from a submucosal tattoo and other dyes. #pathart #pathtwitter #pathology #pathologist #GIpath

▪️Lee Krasner One of the 20th century's most inspiring women artists and a pioneer of abstract expressionism. Her masterpiece “Night Creatures” reminds us of the bone structure seen under the scope. #pathart #pathtwitter #pathology #pathologist #histology

▪️Alma Thomas Recognized as one of the major American painters of the 20th century. Her masterpiece “The Eclipse”, reminds us of how follicular cells and thecal layer arrange around oocytes in ovarian follicles. #pathart #pathtwitter #pathology #pathologist #histology #gynpath

▪️Leonid Afremov The use of his impressionistic spatula is unmistakable and unique. His technique reminds us of the epithelial cells seen in cytological smears. #pathart #pathtwitter #pathology #pathologist #histology #cytopath

▪️Georgia O'Keeffe She captured the endless expanses of clouds as observed from an airplane window. For us, “Sky above the clouds IV” is reminiscent of a nonkeratinized squamous epithelium. #pathart #pathtwitter #pathology #pathologist #histology #GIpath

▪️Gustav Klimt His work with gold leaf reminds us of bile salts, but this isn’t the only aspect of his work. His radiating rings, swirling and concentric spirals reminds us of Hassal corpuscles in the thymus. #pathart #pathtwitter #pathology #pathologist #histology #GIpath

▪️Van-Gogh His thick brushstrokes can capture movement. We think that ovarian stroma has some “impasto” similar to Van Gogh's works. #pathart #pathtwitter #pathology #pathologist #histology #GYNpath #VanGogh

▪️Wassily Kandinsky Credited as a pioneer of abstractionism, his work “Color Study: Squares with Concentric Circles” reminds us of the corpora amylacea seen in prostate. #pathart #PathTwitter #pathologist #uropath #Kandinsky

ART & PATHOLOGY From Kandinsky to Georgia O'Keeffe, it’s almost as if these artists peered into a microscope to find inspirations for some of their works. Follow the 🧵 to see similarities between these masterpieces and benign tissue samples. @DCFpath #pathart #PathTwitter

9/9 Pathologists and clinicians must be cautious of the limitations and pitfalls of morphological diagnosis and be mindful of the tests needed to make organism-specific diagnoses. #DCF_path #pathology #pathologist #PathTwitter

8/9 Hyalohyphomycetes are a diverse group with similar tissue forms, but treatments vary tremendously. Namely, Scedosporium apiospermum does not respond to Amphotericin B, but Aspergillus does. So, by stating that it’s Aspergillus, one may have misdirected the treatment.

7/9 For example: ❌ "compatible with Aspergillus" ✅ "Hyaline, septate, branching fungal hyphae with morphology shared by Aspergillus, Fusarium and Scedosporium, and other hyalohyphomycetes, identification by culture or molecular methods is recommended. " #DCF_path #pathology

6/9 ⚠️ Avoid terminology like "compatible with [ specific fungi ] ” This can limit differential diagnosis and treatment because you can’t ascertain the genus and species. Instead, focus on the description and potential suspects. #DCF_path #pathology #pathologist #PathTwitter

5/9 🍄 A statement in the comments regarding the importance of correlating clinical-epidemiologic features and results of cultures or other laboratory tests #DCF_path #pathology #pathologist #PathTwitter

4/9 🍄 A comment stating which fungi are most frequently associated with the observed morphology as well as other possible fungi and parasites for use in a differential diagnosis #DCF_path #pathology #pathologist #PathTwitter

3/9 🍄 Invasion of the tissues and vessels 🍄 The host’s reaction to the infection (inflammation, necrosis, or hemorrhage) #DCF_path #pathology #pathologist #PathTwitter