Colonic biopsies due to chronic pain are very common in Pathology labs. Chang et al describe mechanisms of hypernociception from IBD in this awesome paper: https://t.co/Rsb2PBrZdq A must read! @DCF_path #GIpath #IBD
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IBS is often diagnosed. Pain from hypersensitivity is the worst part for patients. In this paper they investigated the role of 5-HT7 receptors in mucosal innervation and intestinal hyperalgesia.
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While causes of IBS are unknown, they found a positive feedback loop where 5-HT7 plays a key role. This may lead to a promising treatment using 5-HT7 antagonist which would improve the quality of life for millions of sufferers. So checkout the latest and greatest in this paper!
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