Paolo Actis
@paoloactis
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Nanosurgeon @universityleeds @juventusfc fan
Leeds, England
Joined March 2009
We have developed the most precise "nanoinjection" setup where you can inject biomolecules into cells one at the time . Fun collaboration @RadfordLab @ericcells @aksimentievLab led by the brilliant @chalmerscccc
biorxiv.org
Controlled manipulation of cultured cells by delivery of exogenous macromolecules is a cornerstone of experimental biology. Here we describe a platform which uses nanopipettes to deliver defined...
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Brilliant x-orial (formerly known as tweetorial) on our recent work on nanopore for the real time analysis of biochemical reactions. With a great music reference in the cover @Patrick_Unwin.
Check out our latest work in ACS Nano:.We measured the digestion speed of endonucleases and CRISPR-Cas9 using a solid-state glass nanopore (nanopipette). Quick details below (open access!):.
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RT @RoyalMicroSoc: Our ever-popular #ElectronMicroscopy Spring School is returning to @UniversityLeeds in 2025!. Covers training in both Sc….
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RT @George_R_Heath: PostDoc Position Now Open!.🎞 Join our High-Speed AFM team in Leeds.Application Deadline: 1st September 2024. Apply Onli….
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Team nanopipette for the win.
Finally got to meet @paoloactis in person at the Bioanalytical Sensors GRC after years of following his nanopipette work! Looking forward to finding routes to work together on DNA nanopores! #TeamNanopipette 🧬🥂
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RT @AptaWineClub: Finally got to meet @paoloactis in person at the Bioanalytical Sensors GRC after years of following his nanopipette work!….
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RT @Mitochondri_Al: Thrilled that this paper is finally published! Please check this out if you are interested in how we used nanobiopsy to….
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RT @AmyV91: Congratulations @Mitochondri_Al on your recent paper on the sue of nanobiopsy to study subcellular heteroplasmy! https://t.co/….
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and this is the link to our recent @ScienceAdvances publication
science.org
Nanobiopsy enables the multigenerational, longitudinal sampling of the same cell (and its progeny) over 72 hours.
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You can read more about our technology aiming at breaking the walls of cancer therapy resistance here.
leeds.ac.uk
A groundbreaking nanosurgical tool - about 500 times thinner than a human hair - could be transformative for cancer research and give insights into treatment resistance that no other technology has...
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Happy to be a finalist in the Life Sciences category of the @Falling_Walls #GlobalCall24. Excited for the.Science Breakthroughs of the Year at the #FallingWalls #ScienceSummit24 This is a team recognition for @Fabio_Marcuccio @LucyFStead @nano_chalmers @GeorgetTanner
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RT @KGoepfrich: Why are we so exited about RNA origami? It could be a unique intermediate between DNA origami and proteins for the construc….
biorxiv.org
The central dogma at the core of molecular biology states that information flows from DNA to RNA and then to protein. Our research seeks to introduce a conceptually novel approach towards synthetic...
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RT @Patrick_Unwin: We are open for submissions one week today - 12 June! #ACSElectrochemistry.
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RT @kmkulesa: My favorite & most challenging collab! High-throughput electro-organic synthesis, with automated MS by @ErinHirtzel. @baker_….
pubs.acs.org
Combinatorial electrochemistry has great promise for accelerated reaction screening, organic synthesis, and catalysis. Recently, we described a new high-throughput electrochemistry platform, colloq...
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Massive thanks @epsrc @BBSRC @royalsociety @LeverhulmeTrust @LeedsUniEng @BraggRoyceLeeds @AstburyCentre for making this work possible.
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and the brilliant Chris Maffeo and @aksimentievLab helped us understand the likely reason using MD simulations
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Surprisingly we discovered the cell itself enhances the detection of the molecules delivered
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We can count how many macromolecules are injected into living cells (primary cells and cell lines) one by one . creating the world's most precise cell injection platform
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Delighted to see @chalmerscccc work at the interface of nanopore sensing and cell biology published @NatureComms . Great team effort @RadfordLab @ericcells @aksimentievLab .
nature.com
Nature Communications - Controlled manipulation of cultured cells by delivery of exogenous macromolecules is a cornerstone of experimental biology. Here, the authors describe a platform to deliver...
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RT @ACSPublications: We're proud to announce the launch of ACS Electrochemistry, a peer-reviewed, hybrid journal that will begin accepting….
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RT @warwickchem: We are delighted that our Head of Department, Professor @Patrick_Unwin has been recognised for his invaluable contribution….
royalsociety.org
Over 90 exceptional researchers from across the world have this year been elected to the Fellowship of the Royal Society.
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