Fear #engrams are very popular but what about #SpatialMemory engrams? Here is what we learned about #cFos, #GranuleCells and navigation in freely swimming mice. Check out our paper on @NatureComms carried out at the @OertnerLab 🧵(1/5)

RT @tpatriarchi: Happy to see our new Review out! .Engineering, applications, and future perspectives of GPCR‐based genetically encoded flu….

RT @JasonSynaptic: Thought provoking work here on what kind of neuronal activity is FOS expression really reading out! Especially for taggi….

RT @GraeffJohannes: Just out: Check out our newest review on brain #clearing techniques for #memory #engram research! .

Delighted to hear that our recently published paper was selected by the @UKEHamburg as #PaperOfTheMonth Check it out here:

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RT @TanjaFuchsberg1: (1/5) Reactivation of neurons in the hippocampus is important for memory. So does reactivation induce or modulate syna….

RT @KasiaGrochowsk3: Please share! The PhD position is also available, flyer with more details comes soon!

So. What the Fos is going on? The mechanism preventing repeated cFos expression in granule cells involves… drumroll please 🥁, accumulation of #ΔFosB For this and more about space, time and engrams take a look at our paper🥳(5/5)

Here is where it gets tricky! These “engram cells” do not re-express cFos although they are electrically active! We used #CaMPARI2 to show how WM-tagged cFos cells fire (electrically active) specifically in the WM and yet they rarely express cFos. (4/5)

Using #optogenetics, we found that silencing cFos+ cells from the first WM-training day impairs memory retrieval in novice and expert mice. This suggests that indeed cFos+ granule cells are the “WM engram”, or at least part of it (3/5)

cFos re-expression (encoding vs. retrieval, aka. “reactivation”) is a criterion to define an #EngramCell. We found that cFos expression patterns in the #DentateGyrus change dramatically from day to day in a water maze spatial learning paradigm, regardless of training level (2/5)

I am delighted to finally share the result of 6 years of work. Thanks to all the collaborators and specially to my dear friend and co-first author @franzeasva it wouldn’t have been possible without you.

RT @SimWieg: 9 years ago, when I was a postdoc in @OertnerLab iGluSnFR was published. We ordered it immediately from @Addgene for @CelineDu….

RT @z_chiang: Confused by all the "what is epigenetics" discourse?. Well I have just the thing for you -- presenting the Epigenetics Alignm….

I feel 🐁C57BL/6 mice are underrepresented in the internet. I decided to make my own drawing and it looks pretty cute

Paper status: Resubmitted .COVID status: Reinfected .Overall status: 🕺🏻🦠 🎉 😴.

3 months since my last stereotaxic AAV injection. I though it was gonna be rough but everything went sooo smoothly. I guess it's almost like riding a bike 💉🧠🚴‍♀️.

Thanks to everyone who came to my poster. Super enriched discussions and excellent questions. It’s so rewarding to finally meet again in person and talk about amazing science.

So excited to be able to present in person again. Please join me for a discussion on how cFos temporal instability might contribute to pattern separation of memories. Today at #FENS2022 (Sun. July 10th at 14:00). #Engram #Optogenetics #SpatialMemory