
Myant Lab
@myantlab
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Colorectal Stem Cell Transformation lab. Our lab investigates stem cell transformation in the colon with the aim of identifying novel pathways that drive it.
Edinburgh, Scotland
Joined March 2016
RT @EdinUni_IGC: How cancer resists treatment is the focus of a £1.5million @CR_UK project led by @HobbRollis at #IGC and @CRUK_SI to fin….
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RT @heraldscotland: Scots scientists make key discovery in how bowel cancer is able to disguise itself.
heraldscotland.com
Scottish scientists have made a key discovery in how bowel cancer is able to disguise itself.
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RT @CRUKScotland: Our researchers @EdinUni_IGC @uniofedinburgh have discovered that aggressive bowel cancer cells are able to "shapeshift"….
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@weepatri @Nature This was a huge collaborative effort across the @EdinUni_IGC, @EdinCRC, @CRUKScotland and @CRUK_SI with funding from @CRUK, @ERC and @MRC. Massive thanks to all involved - @RaponiMichela @yrhong_91, @aslibastem, @SebastianPohl, @ColinWSteele, @owen_sansom and others not on X!.
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@weepatri @Nature We found the chromatin remodeller ATRX maintains colonic gene expression and its loss ‘softens’ colonic identity. This allows squamous and mesenchymal-like cell states to emerge, suggesting loss of colonic lineage fidelity is a key driver of cancer cell plasticity and metastasis.
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Excited to share our new study led by @weepatri published today in @Nature. In this project, we identified loss of colonic identity as a key step enabling multilineage plasticity and metastasis in colorectal cancer….
nature.com
Nature - The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.
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RT @aslibastem: Excited to share my PhD preprint now out on bioRxiv! @myantlab. We explore the role of RNA modification enzyme NSUN2 in col….
biorxiv.org
Colorectal cancer is initiated by loss of the APC gene, which drives expansion of LGR5+ intestinal stem cell (ISC) populations. Whilst LGR5+ ISC expansion is a critical step for tumour initiation and...
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Delighted to share a recent preprint from the lab! . We find a role for the RNA methyltransferase Nsun2 in controlling stem cell expansion and tumour initiation via MAPK activation. Fantastic work by @aslibastem during her PhD and everyone else involved! .
biorxiv.org
Colorectal cancer is initiated by loss of the APC gene, which drives expansion of LGR5+ intestinal stem cell (ISC) populations. Whilst LGR5+ ISC expansion is a critical step for tumour initiation and...
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RT @WeeJambos: The Heart of Midlothian Girls’ Academy🇱🇻. Yesterday evening our G13s, G15s and G17s got their team, and individual, photos t….
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@amd_churchhouse Thanks also to all the co-authors and collaborators who helped massively with the study Caroline Billard, @ToshiM32 , @SebastianPohl , Nora Doleschall , @PathologyEdin , @ShahidaDin1 , @Kriegsheim_lab and @CoffeltLab.
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The study was led by @amd_churchhouse who has written a blog post covering the key findings:.
communities.springernature.com
In this paper we identify Dock2 as an immune regulator in IBD-CRC, with potential therapeutic opportunity in this area of unmet clinical need.
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Delighted to share the most recent work from our lab where we identify a role for DOCK2-loss mediated immune dysfunction in IBD-associated colorectal cancer. Great work @amd_churchhouse ! .
nature.com
Oncogene - Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression
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RT @amd_churchhouse: Excited to share my PhD work from @myantlab, published today in @Oncogene. Full text (open access): .
nature.com
Oncogene - Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression
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RT @Joharrr: Fully funded PhD studentship to join us @UofGCancerSci and study microbial metabolism in IBD-associated CRC!! . Very much look….
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RT @RachelGuest1: We are looking for a Research Assistant to join our fabulous new group at @EdinUni_IGC studying liver plasticity and canc….
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Massive congratulations to Asli @aslibastem for passing her PhD viva with flying colours on Friday! Thanks also to @liamfaller and @AlanSerrels for examining! 🎊🎊🎉🎉
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RT @Edin_Football: First P7 festival of the year @Oriamscotland . Thanks to @WLCF_1 @EL_Football_Dev and of course our own players. 12 hi….
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RT @FrontCellDevBio: New Research: Be like water, my cells: cell plasticity and the art of transformation: Cellular plasticity defines the….
frontiersin.org
Cellular plasticity defines the capacity of cells to adopt distinct identities during development, tissue homeostasis and regeneration. Dynamic fluctuations ...
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