Abhijit (Jeet) Naik
@minimalchange
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Physician-Scientist at large @UMich, Informatician, always in flux regardless of pore size. Tweets are my own views and not medical opinion.
Ann Arbor
Joined April 2011
JCI Insight - The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure
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We propose GH-IGF1 mediated signaling as a potential risk factor for long term kidney allograft survival.
medrxiv.org
Introduction Maladaptive hypertrophy and podocyte stress and depletion contribute to kidney function decline. Although IGF-1 plays a key role in early hypertrophic responses in the single kidney...
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Blazing-fast image creation – using just your voice. Try Grok Imagine.
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Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy
biorxiv.org
Rationale We take a unique approach to understanding the causes of podocyte injury in collagen IV nephropathies, a crucial step in developing targeted therapies for conditions like Alport Syndrome....
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RT @AJKDonline: In the Literature commentary by @minimalchange and Frank C. Brosius:. Cannabinoid Signaling in the Diabetic Proximal Tubule….
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Identification of glomerular cell type stress after kidney transplant at a single cell resolution. We observed significant reduction in nephrin and key integrin (ITGA3) both at an mRNA and protein level. Thanks KPMP, HCA, NIDDK. @MiKTMC @UMichKidney.
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The timing of ACE inhibition in relation to uni-nephrectomy has significant impact on hypertrophic stress associated single kidney outcomes. Ramifications for kidney transplantation and live donors?.@UMichKidney @UMIntMed.
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RT @minimalchange: Urine marker analysis identifies evidence for persistent glomerular podocyte injury across allograft lifespan https://t.….
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Urine marker analysis identifies evidence for persistent glomerular podocyte injury across allograft lifespan . Our heuristic approach in testing the idea that podocyte injury and detachment continue across lifespan of allograft. @UMichKidney.
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SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease . @MiKTMC @UMichKidney @umichmedicine @Berthiercc @OlgaTroyanskaya .
kidney-international.org
COVID-19 morbidity and mortality are increased via unknown mechanisms in patients with diabetes and kidney disease. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry into host cells....
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RT @NadaAlachkar: I think it is a very important cause of late kidney allograft failure! #ATC2020Virtual
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New from a fantastic group @MiKTMC /Princeton as preprint that leverages the power of scRNAseq to demonstrate how cells in pathologic environments (e.g. diabetes) have their cellular machinery primed for viral (SARS-CoV-2) entry.
medrxiv.org
COVID-19 morbidity and mortality is significantly increased in patients with diabetes and kidney disease via unknown mechanisms. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry into...
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See our paper in KI that uses nephron segment specific urine mRNAs to explore how systemic blood pressure might initiate and drive subclinical glomerular injury and affects glomerulus >> tubular compartments. @UMichKidney @UMIntMed @MiKTMC @Kidney_Int.
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RT @MiKTMC: 1/7 We just published a new single-cell transcriptomics study in @JCI_Insight using @KPMP, #NEPTUNE, and #ERCB data. https://t.….
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See our article on impact of donor BMI on kidney allograft outcomes and an accompanying editorial @UMichKidney.
Kidneys from overweight and #obese deceased and living donors are associated with a graded increased risk of #graft #failure @minimalchange
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University of Michigan spends record $1.62 billion on research in 2019
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Dustin our star resident (University of Michigan) describing his work at Kidney week to KIDNEY STARS.@UMichKidney @MiKTMC
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Publish houses of brick, not mansions of straw : Nature News & Comment via @NatureNews.
nature.com
Nature - Papers need to include fewer claims and more proof to make the scientific literature more reliable, warns William G. Kaelin Jr.
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The temporal and long‐term impact of donor body mass index on recipient outcomes after kidney transplantation ‐ a retrospective study
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