Martin Mittag
@midimittag
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Comp Neuroscience, Physics, 3R Centre Giessen, ESI Frankfurt
Joined November 2015
We are excited to share our new paper "Modelling the contributions to hyperexcitability in a mouse model of Alzheimer's disease (AD)”. 😊.A great collaboration with @lsmediavilla, @jedlickap, @ComputingCajal and @SR_neurostar (1/4)👉.
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RT @ximica1: It’s been a while, but it’s never too late to share good news: this year I officially became a Dr. 🎊😁!! I can’t express enough….
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RT @ximica1: Our study uncovering the functional architecture of #dopamine neurons driving #FearExtinction learning is out in @NeuroCellPre….
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RT @jedlickap: The skewed distribution of synapse sizes is surprisingly little affected by synaptic activity and activity-dependent plasti….
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If you like this workshop, join our intriguing poster sessions (#30 and #85) @CNSorg on July 16 regarding optimising dendritic diameters and Pareto optimal granule cells for pattern separation and energy efficiency :).
Excited to announce our workshop @ CNS*2023 Leipzig (@CNSorg) on "Optimality, Evolutionary Trade-offs, Pareto Theory and Degeneracy in Neuronal Modeling" w/ @jedlickap, @AlexNeurosci July 18 & 19, Leibniz Room. Talks by Astrid Prinz, Tim O'Leary, Anna Levina et al. CU there! 1/2.
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RT @jedlickap: I am very much looking forward to our upcoming workshop on Pareto optimality, evolutionary trade-offs, and degeneracy in neu….
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Our results are in line with multi-causality: multiple different disruptions (such as pathological network and ion channel changes) are separately sufficient but no single particular disruption is necessary for neuronal hyperexcitability. (4/4).
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Possible scenario 1: enhanced excitation/inhibition (E/I) ratio.Possible scenario 2: alteration of intrinsic ion channels (IAHP down-regulated; INap, INa, ICaT up-regulated) in addition to enhanced E/I .Possible scenario 3: burst hyperactivity of the surrounding network (3/4).
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Dendritic degeneration alone can change the pyramidal cells (PCs) responses to layer-specific input but additional pathomechanistic scenarios are required to explain neuronal hyperexcitability - especially increased bursting - in APP/PS1 mice as follows: (2/4).
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RT @jedlickap: Our new preprint about the activity-independence of lognormally distributed spine sizes:.
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RT @biorxiv_neursci: Robust and consistent measures of pattern separation based on information theory and demonstrated in the dentate gyrus….
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RT @danylobatulin: I am happy to share our article on principles of epilepsy development after injury.#epilepsy #neurology #epileptogenesis….
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RT @cnl_mbu_iisc: Degeneracy in epilepsy: Multiple Routes to Hyperexcitable Brain Circuits and their Repair. Tristan Manfred Stöber @trista….
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RT @jedlickap: Which ion channel parameters from a huge theoretically possible parameter space are present in real neurons? In our preprint….
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RT @jedlickap: Check out our new paper at .@NeuroCellPress. We show that realistic neuron models with a large variety of dendrites display….
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RT @HCuntz: Our paper on dendritic constancy has been published at @NeuroCellPress. It is abundantly clear that dendritic trees shape the c….
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I am happy to have contributed on active compartmental models (Spruston, Poirazi, Korngreen) to show spike responses within the context of dendritic constancy. link:
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After intensive simulations and revision work over the past year we finally have our new paper out: A general principle of dendritic constancy.
Our paper on dendritic constancy has been published at @NeuroCellPress. It is abundantly clear that dendritic trees shape the computations that neurons perform. But here we show an input-output relation that is largely independent of dendritic length and branching.
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RT @RenaudJolivet: This is on right now! Join us @CNSorg #CNS2021Online to learn all about Computational Gliosciences! #glia2021
https://….
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