Kou-San Ju
@microhabitat
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Associate Professor of Microbiology, MedChem & Pharmacognosy at The Ohio State University. Antibiotic hunter, enzymes & systems biology ✈ All tweets are my own
Joined August 2014
We are hiring at Ohio State University! The Department of Microbiology invites applications for a tenure-track position at the Assistant Professor level in the area of microbial cell biology. Come join us! https://t.co/U9c3RBETN5
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We are hiring at Ohio State University! We have an open-rank, tenure-track faculty position within the Division of Medicinal Chemistry & Pharmacognosy, in all areas of small molecule drug discovery. #chemistry #drugdiscovery #facultysearch
https://t.co/ix1SXD84fP
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lol
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...And also an accompanying paper by @YeyingZhang et al published in @J_A_C_S describing the complete #biosynthesis pathway of valinophos, the origins of new #phosphonate #naturalproduct scaffolds, unexpected ATP-Grasp ligase activities, and new metabolitc branch-points.
Valinophos Reveals a New Route in Microbial Phosphonate Biosynthesis That Is Broadly Conserved in Nature @OhioState @MicrobiologyOSU @OSUPharmacy @CAPS_OSU #Valinophos #Microbial #Biosynthesis #Conserved #Phosphonate
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We’re delighted to publish our latest on #phosphonate #biosynthesis in @J_A_C_S! @YeyingZhang et al deciphered the complete pathway for the #antimicrobial #naturalproduct argolaphos, the origins of two non-canonical amino acids, and a new diverse group of oxygenase enzymes.
Biosynthesis of Argolaphos Illuminates the Biochemical Origins of Aminomethylphosphonate and Nε-Hydroxyarginine Natural Products @OhioState @MicrobiologyOSU @OSUPharmacy @CAPS_OSU #Biosynthesis #Aminomethylphosphonate #Hydroxyarginine #NaturalProducts
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So it's been mentioned that our lab runs really long chromatography columns...
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Really nice obit for Tom Brock. RIP master environmental microbiologist.
nytimes.com
In 1966, he found heat-resistant bacteria in a hot spring at Yellowstone National Park. That led to the development of the chemical process behind the coronavirus test.
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And here's more: "Nature’s Bounty: Revitalizing the Discovery of New Cancer Drugs from Natural Products" https://t.co/na8aNyRznK
#NCICancerCurrentsBlog @NCIResearchCtr
cancer.gov
Mining natural products for leads on new cancer drugs is getting a boost from a new NCI initiative funded by the Cancer Moonshot.
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NCI’s Dr. Barry O’Keefe discusses cancer drugs developed from natural product extracts in the documentary #ExtinctionTheFacts. Here’s a clip: https://t.co/xJRgKJeHjg
@BBCOne #NCIintheNews
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LAST CALL for apps for our new Genentech postdoc prog that accepts based on potential, rather than fit for a posted lab opening. We're esp interested in diverse backgrounds. Apps due Mon! Comes with industry experience and a competitive postdoc salary ($80k)+benefits.
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Brilliant piece from @SeanBiolCarroll in @TheAtlantic on my scientific heroes Jacques #Monod - a brilliant scientist and a man of the utmost integrity- check out Sean’s book ‘Brave Genius’ to find out more too
theatlantic.com
Jacques Monod saw chance as one of the “secrets of life,” an idea he used to tear down all sorts of dogmas.
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Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface https://t.co/xXNDh0SYPn Congrats to my former WarpDrive Bio colleagues and team! Would be amazing for these compounds to find use in COVID-19 control!
pnas.org
The vast majority of intracellular protein targets are refractory toward small-molecule therapeutic engagement, and additional therapeutic modaliti...
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Excited to share our recent #genomemining paper in @ChemicalBiology on discovery of the phosphonoalamides, antibacterial peptide natural products produced via a new route in #phosphonate biosynthesis. Congratulations to @Chase_lol @YeyingZhang
https://t.co/Sp0cet2oIA
pubs.acs.org
Phosphonic acid natural products have potent inhibitory activities that have led to their application as antibiotics. Recent studies uncovered large collections of gene clusters encoding for unknown...
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We have an open tenure-track position within the Department of Microbiology at the Assistant Professor level in the area of Bioinformatics and Computational Biology. Please see:
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When the deliver guy arrives with a pallet and you realize its the 20 cases of Petri dishes you ordered... #microbiology
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The beautiful @AmericanAir #aircal livery at MIA. Always nice to see a piece of the Golden State @CalBand
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