It's good to take a break sometimes.

Meet the winners! Based on expert review and social media impact, the five winners of the 1st cycle of Megabase Spark to receive 100 kb of rBlocks™ synthetic DNA are: 🏆 @mcrae_ewan (Houston Methodist) 🏆 Scott Pownall (Open Science Network Society) 🏆 @theicechol (Institute for

I'm honored to join the 2025 class of Pew Scholars in the Biomedical Sciences. This program has supported an extraordinary community of scientists, past and present, whose work I deeply admire. I am grateful to be part of this legacy! https://t.co/Ao5Xbnj6Rx @pewtrusts

https://t.co/6pE4Wx7R8s

New lab space!

I'm always happy to hear feedback from my peers, feel free to DM or email me with any questions or thoughts.

Read this #preprint on @researchsquare: Base modifications reshape RNA folding landscapes and structure–function relationships in synthetic and natural RNAs

We use cryo EM, MP, FRET and activity assays to understand the effects. The tl;dr is that these base mods don't change the secondary structure (for these RNA) but do alter the tertiary structure and activity through modulation of base-stacking choices at helical junctions.

First manuscript from my lab is now under review! To investigate the effects of modified nucleotide bases commonly used in mRNA therapeutics on RNA 3D structure and function, we synthesized two well characterized RNA with either 5mC or N1m-pseudoU.

We welcome the first ever #MegabaseSpark submission, from @mcrae_ewan: "We’re building a synthetic library of RNA sequence variants to map how mutations reshape RNA folding and function. By encoding thousands of designed variants in synthetic DNA, we aim to uncover design rules

Interested in starting or continuing a lab geared towards RNA therapeutics? Come work in Houston! https://t.co/LSghm6YYYW

All systems are go!!

Well... it's a start.

Hi #RNA researchers out there. Since Brandel is out of business, does anyone know where we can get replacement parts for thier fractionator? Right now, we're looking for these gasket sets. in particular size c

Hello X network! My lab is currently looking to hire a post-doctoral researcher to work on the design and characterization of RNA nanostructures with therapeutic applications. https://t.co/wyRjaZO23h Should you or anyone you know of be interested, please do reach out!

Join our #18 webinar of a series on RNA structure, CASP-RNA-Sig: “RNA Texas Fold 'em: One step to the right, run me to the left, spin me in the middle?” by @qvicens, April 23 PDT8am/EDT11am Join the Google group! https://t.co/RZVzHClMc3 @RachaelKretsch #rna #casprnasig

$10 from amazon for the magnets and $0.75 for the plastic resin makes me feel like I avoided highway robbery.

Saving tax payer money one 3D print at a time.

Join us on April 2nd at 1 PM Mountain for the Gulf Coast Consortia Speaker Series, where I will discuss our recent work on RNA G-quadruplex identification and functional studies. Thanks to Dr @mcrae_ewan and colleagues @MethodistHosp for this invitation! @uLethbridge @UofLArtsci

CryoEM unveils structure of nano-sized 'RNA copy machine,' a key player in the ancient RNA world. This breakthrough may fuel RNA nanotech and medical advancements. 🧬 @esandersen, @PhilHolliger, and @mcrae_ewan et al. publish findings in PNAS (@PNASNews). https://t.co/HdKtBI90Es