Meet the winners! Based on expert review and social media impact, the five winners of the 1st cycle of Megabase Spark to receive 100 kb of rBlocks™ synthetic DNA are: 🏆 @mcrae_ewan (Houston Methodist) 🏆 Scott Pownall (Open Science Network Society) 🏆 @theicechol (Institute for

We are excited to share another #MegabaseSpark submission, titled 'Bio-Based Petrochemicals' from @sean_wirt: "We plan to survey enzymes for activity on non-native substrates, enabling the construction of novel metabolic pathways for bio-based commodity chemicals traditionally

We are excited to share another #MegabaseSpark submission, from @ChrisBatianis: "We wire cell growth to enzyme function: if the enzyme fires, the cell thrives. Thousands of variants turn growth into activity data that train LLM models to design better proteins. Synthesised

We are excited to share another #MegabaseSpark submission, from @nehastar03: "We bioengineer microbial biosynthetic gene clusters (BGCs) to unlock cryptic pathways and discover novel antimicrobial compounds. Using heterologous expression and rational design, we aim to produce

We are excited to share another #MegabaseSpark submission, from @AmodRBhat: "Tick-borne flaviviruses are stealthy, neglected threats endemic to me but ignored globally. Tired of watching research stall behind biosafety barriers, I intend to engineer "MiniFlaviReps" that are

With the deadline approaching, we are excited to share another #MegabaseSpark submission, from @HansGerstmans: "Synthetic refactoring and optimization of a biosynthetic gene cluster encoding a potent anti-breast cancer natural product, to improve potency and production in a

Happy Friday! We got a new #MegabaseSpark submission from @lly_sam1: This research uses synthetic biology to determine if all 20 canonical amino acids are essential for life. By designing and testing proteins with fewer amino acids in bacteria, we aim to uncover fundamental life

We welcome the first ever #MegabaseSpark submission, from @mcrae_ewan: "We’re building a synthetic library of RNA sequence variants to map how mutations reshape RNA folding and function. By encoding thousands of designed variants in synthetic DNA, we aim to uncover design rules

4/ 🗓️ First deadline: June 30 🧬 Apply with a brief project summary, a catchy title, and DNA requirements 🌍 Open to academic, nonprofit researchers as well as entrepreneurs worldwide Apply and learn more here →

3/ Every quarter, we’ll select proposals from researchers with promising ideas and limited resources that generate popular support (Fan Favorites) or demonstrate exceptional scientific merit (Professional Picks). Winners receive free rBlocks™ DNA — RootPath’s high-quality,

2/ Why? The high cost of gene synthesis is still a major bottleneck for early-stage research. Megabase Spark is here to change that — empowering scientists to generate critical preliminary data without budget barriers.

1/ 🚨 Today we’re launching something big: Megabase Spark — RootPath’s new initiative to support bold, underfunded research with free synthetic DNA. We’re giving away 3 million base pairs through 2026. Details 👇 #MegabaseSpark

Our founder Dr. Xi Chen will be at SynBioBeta 2025 and speaking on the panel “Deconstructing Cellular Diversity: Single‑Cell Sequencing for Drug Discovery & Synthetic Biology,” Thursday, May 8 at 2:30 p.m. Join us to discuss how next-generation gene synthesis technologies and

Did you know? Since launching our gene synthesis service in late 2023, we have shipped over 35,000 constructs to customers in the US, China, Singapore, and the European Union — averaging nearly 700 constructs per week. Thanks to our novel synthesis technology, we routinely

Did you know? You can save $32K on gene synthesis for a metagenomic mining project that would otherwise cost $63K. In other words, >50% SAVING! Order today: https://t.co/L3oGx3n3Fl #DNA #SynBio

We are proud to launch RootPath Custom Gene Library in the US, slashing gene synthesis cost by more than half, to as low as $0.04/bp. Let RootPath double your screening throughput with the same budget! Learn more from our official announcement:

We’ll be at #SITC22 this week presenting 3 posters on the discovery of #tumor reactive TCRs in various applications of our proprietary platforms: Pathfinder, Interpreter and DisPATCH. More details are available here: https://t.co/xY6I8qrQb7

We are proud to announce that RootPath’s scientific and technology leaders will present on approaches to #TCell therapy at #SITC22 this November. Learn more here: https://t.co/NlU6mW0sq4 #SITC2022

Our Co-Founder & CEO Xi Chen shared his thoughts with @GenomeWeb: "Key values in biotech in the next 10 years will be created by going back and forth between sequences and functional readouts. What we're going to do is remove the speed bumps in between."

Come see our CEO and Co-Founder Xi Chen today present ‘What to do with Limitless Gene Synthesis: T Cell Therapy & Beyond’ at 12:30PM PDT at the #BuiltWithBiology conference! (Oakland Room, 3rd Floor)