Antonio J. Pérez Pulido
@ajperezpulido
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Bacterial CRISPR lover (they found me), phages (they find them), and SMA patient and researcher (I found it). I admire Acineto as an example of self-improvement
Sevilla
Joined November 2009
Bluesky’s science takeover: 70% of Nature poll respondents use platform
nature.com
Nature - Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
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Gracias por contar la historia de estos belicosos virus de bacterias. .
🔬 El grupo investigador #UPOBioinfo revela un fascinante conflicto entre bacteriófagos (virus que atacan bacterias), en el genoma de la bacteria #Acinetobacterbaumannii, una de las más resistentes y peligrosas según la #OMS. Publicado en Cell Reports, este avance puede ser
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All this we have been able to study using computational biology to analyze thousands of genomes of the bacteria and of the phages. Watercolor showing the PPTOP vs DgiS1 warefare made by Silvia Cano Martos. More on bluesky.
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DgiS1 carries other defense systems and defends itself against the CRISPR-Cas system of PPTOP by PAM escape. And this warefare takes place in a tmRNA of the bacterial genome, in which either DgiS1 or the CRISPR-Cas system is integrated, depending on who wins. .
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We present the full story of the PPTOP vs DgiS1 phage battle using Acinetobacter baumannii bacteria as the battleground. PPTOP is a phage-plasmid that, among other weapons, carries a CRISPR-Cas I-Fa system specialized in targeting DgiS1.
cell.com
Rubio et al. describe an archipelago of anti-phage systems in the opportunistic pathogenic bacterium A. baumannii. This is the battleground of two phages fighting for integration. One of them inserts...
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‘El peor vecino del mundo' Qué preciosidad de película.
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In addition, both groups differed by their phage profile. But this is only the beginning of a nice story. @agarvil @arubval @smani_lab.
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And more specifically, we have found that part of them have classical restriction systems based on methylation, and another important part have systems based on phosphorothioation.
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First paper of the thesis of @antoniomore97, in which we show how the pangenome of A. baumannii is divided according to the defense systems that present their genomes.
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The defensome of Acinetobacter baumannii reveals two genome groups according to their innate defense systems and phage profile
biorxiv.org
Phages are guilty of killing daily almost half of bacterial cells, while bacteria have developed defense mechanisms that number in the dozens. Individual defense systems are gained and lost by...
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Ya tengo cita con mi médico. ¡Para el día 6 de noviembre! Así que mientras tanto, vamos para urgencias.
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No hay citas disponibles en la app de salud responde nunca, no cogen el teléfono y en la puerta del centro de salud una cola que se sale por la puerta. ¿Forma esto parte de algún plan?.
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¡Qué bien! Me dice Mr. Google que he hecho 3km en bici. Poco a poco. Mañana más. 🚴🏽♂️.
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¡Qué buenas jornadas hemos pasado este finde en Madrid! Gracias por todo el trabajo que hacéis con la #AME @FundameNet.
FundAME reclama seguir impulsando la #investigacion de la #AME en las Jornadas de Familias. Más de 230 personas se reunieron para compartir avances y experiencias de esta #enfermedadrara .Patrocinadas por @NovartisSpain @roche_es @biogen @ScholarRock @NMDPharma y @OximesaNG
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RT @McCarthy_Ronan: Delighted to have some of our work on plastic degrading biofilms showcased in this Feature article.
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🤣.
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RT @IsabelAlmudi: Una enfermedad rara como desafío: una bióloga sevillana investiga un mal que solo sufren 600 personas en el mundo https:/….
eldiario.es
Gloria Brea Calvo, profesora e investigadora de la Universidad Pablo de Olavide, impulsa la investigación del síndrome de deficiencia de coenzima Q, que padecen solo 600 personas en todo el mundo
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