Matthew Wilcox
@mattwilcox05
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Foundation Doctor, Oxford Rotation and Research Fellow, UCL School of Pharmacy
London
Joined December 2017
New paper from @poppyosmith reports the production of #EngineeredNeuralTissue using a new automated manufacturing approach. This tissue engineering technology was used to make nerve repair constructs containing stable aligned endothelial cell structures. https://t.co/4fBRhzFxpf
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The end of a long day of discussion on all aspects of traumatic brachial plexus injury. Our @LindAlliance day we have arrived at a top ten! Results are under embargo and will be released during TBPI week (Oct 20-26th) Thankyou to the steering group, facilitators & today’s group.
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Introducing our 2024-25 cohort of UK Scholars to the USA! Our scholars are poised to make a global impact in their fields. Join us in wishing them the best on their exciting journeys across the pond! Learn more about our incoming cohort of Fulbrighters: https://t.co/QLpX5YJ8Aa
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Dysmetria and an earlier onset of muscular fatigue are important pathological features of muscular function after nerve trauma. For the first time, our latest paper identifies and quantifies co-contraction as a key contributor to these characteristics of reinnervated muscle.
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A massive thank you to @UCLTRO @BSSHand @scarfreeworld @rcpsglasgow for funding this conception and to @BAPRASvoice @DominicFurniss @TJQPNI @hoopoe_swana @CNS_PNI @RNOHnhs for supporting the ongoing human trials to translate these data into patient benefit.
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Early surgical referral where appropriate is important because we know some of the key cells which support nerve regeneration start to deteriorate after around 3 months after injury
link.springer.com
Acta Neuropathologica Communications - Nerve regeneration is a key biological process in those recovering from neural trauma. From animal models it is known that the regenerative capacity of the...
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This study addresses challenges identified by nerve trauma patients and clinicians who tell us conventional diagnostic tests (such as EMG and MRI) are often difficult to access and interpret. This can delay referral to reconstructive nerve surgeons.
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https://t.co/9LTFcatjw1 In this pre-clinical study @PhillipsLab @PNIResearchUnit we show a blood test called serum NfL can objectively screen for nerve trauma in the first few days after injury. The method is around 80% cheaper and faster to perform than conventional tests.
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For Gi, renal, cardiac & respiratory disease infections cancer & inflammation bloods tests can assess the severity of the condition to Dx & assess Tx. In nerve injury this has not been possible: we publish data on a possible option. Human data will follow
onlinelibrary.wiley.com
Background Optimal functional recovery following peripheral nerve injuries (PNIs) is dependent upon early recognition and prompt referral to specialist centres for appropriate surgical intervention...
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@PNIResearchUnit @TJQPNI @hoopoe_swana @DominicFurniss Read more about our translational approaches here: https://t.co/a2c3L7e2wv… Grateful to have been a small part of this team!
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Here we used Motor Unit Number Estimation (MUNE) to show PI3Ka accelerates nerve regeneration. This is part of a wider effort developing MUNE (and other biomarkers) to facilitate clinical translation of therapies developed in the lab. @PhillipsLab @PNIResearchUnit
Activation of PI3Ka opens up exciting new opportunities in regenerative medicine research https://t.co/HQpJ1IzYG1. Very pleased to be part of this great collaboration @CellsigL @UCLTRO @GraceQGong @VickoirR and many others.
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Help influence the future of research into Traumatic Brachial Plexus Injuries. Share the questions you want answered by research in @JlaTbpi survey with @Lindalliance here: https://t.co/0dKYRwX3qM Survey is open until the 1st June, 2023. #TBPIPSP
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Clinicians and patients what questions do you have about Traumatic Brachial Plexus Injuries? Tell us the questions you want answered by research in @JlaTbpi survey with @LindAlliance here: https://t.co/u073TpMTiy
#TBPIPSP
docs.google.com
Have your say and help shape future research! What is this survey about? Traumatic Brachial Plexus Injuries (TBPI) are life changing and can lead to permanent changes in the function of the arm and...
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The study benefits from new collaborations between experts in muscle imaging @UCL_QS_CNMD , clinical nerve injury experts @TJQPNI @hoopoe_swana @PNIResearchUnit and translational scientists @UCL_NerveEng
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This study builds on our previous work explained here https://t.co/O88PFyxmQR This final phase of the project will provide data needed to conduct long awaited clinical trials of novel therapies for nerve repair.
ucl.ac.uk
An interdisciplinary group of researchers in a study led by UCL have identified a new way to track nerve regeneration in humans using MRI.
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Excited to start as an Early Career Research Fellow @OR_UK this year hosted by @PhillipsLab @PNIResearchUnit @School_Pharmacy. The position comes with £110k to develop a new imaging based approach to measure muscle recovery following nerve injury.
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@PNIResearchUnit @hoopoe_swana @mattwilcox05 @LeedsPlexus @studyCOMBINE @TBPIUK @DeanBoyce6 @dominicpower1 @PhillipsLab @UCL_NerveEng @c_ahern26 @LindAlliance
Our steering group (representatives of patient experience & clinical expertise & our wonderful facilitator Katherine Cowan) met online today working towards the publication of our @LindAlliance protocol document. This process will soon lead to us inviting everyone to contribute
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This week is #brachialplexus awareness week. We are leading a JLA process to highlight the challenges faced by these patients so that researchers can identify solutions #JLAPSP @TBPIUK @LindAlliance @BSSHand @RNOHnhs @UCL_NerveEng @hoopoe_swana @TJQPNI
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