Matt Mandel
@matthewjmandel
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investor @usv | ordinary reasoning rendered persistent
NYC
Joined January 2015
RT @asimon_says: I'm excited to share that my Recent Case Comment was published in the June issue of the Harvard Law Review! I wrote about….
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TIL Vimeo was started a year before YouTube as a CollegeHumor skunkworks project. Good example of new infrastructure being developed out of necessity by app-level innovators (a phenomenon @nickgrossman and @thedanigrant dubbed “the myth of the infrastructure phase”)
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RT @shelbynewsad: AMA with @bryan_johnson . Micro plastic reduction (@trevor_klee), Pareto frontier of blood testing (@RobbyWade6, @kenneth….
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RT @mackenziejem: Great research day from @shelbynewsad. An idea that stuck with me was reformulating over the counter supplements to feed….
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Sorkin’s gonna over-rotate on making sure no one leaves this inspired by Zuck isn’t he.
‘The Social Network Part II’ is officially in development, with Aaron Sorkin returning—this time as director.
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RT @grant_brewster: Shoutout to @bryan_johnson for answering my question about microplastics at the @usv Biohacking Demo Day . Had a ton of….
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This was so incredibly fun– thanks to everyone who came out and made today such a mindblowing experience. And special thanks to all of our presenters:.@benjileibo / Pump Science.@trevor_klee / NeutraOat.@kubla / Fulcra.@EvanZhao6 / Pacagen.@RobbyWade6 / Rythm.@oldestasian /.
In the fall, we hosted an incredible Biohacker Research Day with our friends at @CompoundVC. Since then, we've felt the field accelerating. We've been amazed by the talent coming in and the truly mind-blowing things people are working on. In that spirit, we were inspired to.
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RT @kaminskymethod: This event was a highlight of the last month. Thank you to @usv @matthewjmandel @usvlibrarian for hosting.
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RT @emmanuelBHarel: Haven’t been to an event this exciting in a long time…. 🗽Biohacking Demo Day 2.0: @usv x @CompoundVC in NYC. The future….
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Is AI progress studies’ killer use case.
The rise of nuclear weapons accelerated game theory's development as a way to help society reason about their proliferation and use. Today, no one knows how to respond to AI, in part because we don't know how quickly it's progressing. The titotal / AI 2027 exchange really makes.
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The foundation model war is a fascinating case study in what matters in a leader. Sam is a great company builder and communicator but never did AI research. Dario was a leading AI researcher but hadn't led an org before Anthropic. As Meta reorganizes their AI efforts around Alex.
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The rise of nuclear weapons accelerated game theory's development as a way to help society reason about their proliferation and use. Today, no one knows how to respond to AI, in part because we don't know how quickly it's progressing. The titotal / AI 2027 exchange really makes.
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RT @usv: On June 24th we’re bringing together leading optimizers, operators, scientists, and all those in between, for a focused discussion….
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People don't sufficiently appreciate technology's ability to cut through wicked moral and societal problems. Eg it's hard to deny that animal welfare is a huge issue. But outright banning factory farming or animal drug testing is unrealistic. It's hard to look the problem in the.
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In (partial) defense of contemporary feuilletonism.
Classical civilizations told stories about a great past from which they had fallen. After the Industrial Revolution, and especially after WWII, we started telling sci-fi stories about a great future we might build towards. People like to bash our media environment for being hyper.
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Classical civilizations told stories about a great past from which they had fallen. After the Industrial Revolution, and especially after WWII, we started telling sci-fi stories about a great future we might build towards. People like to bash our media environment for being hyper.
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It's pretty cool that @VerveTx is using gene therapies to go after huge indications. Not sure how repeatable that will prove to be. But if they succeed, the scale they'll operate at will have to be great for accelerating further gene therapy progress. Exciting acquisition for.
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I hadn't realized Brex had already raised $300mm before Ramp raised their first round. Pretty wild to go head-on against a well-funded competitor like that.
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