An excellent programme with fantastic talks! Inspiring to see the cross speciality work on frailty 👍 Thanks to @colki1983 and @DrTerryQuinn the invitation to speak on Supporting Older Adults with Cancer. @JGeriOnc @SIOGorg @YoungSIOG.

Excellent session at #UKOF25 focused on Older Adults with Cancer, highlighting the current challenges and models of care in the UK. @kwokleungcheung @EtienneB66 @DrKirstyB @jenny_welford @JGeriOnc @YoungSIOG @siognah

The #UKOF25 treating the older cancer patient session has begun with @EtienneB66 giving an excellent update on trials in older adults and emerging data from ASCO! @JGeriOnc @YoungSIOG @siognah

RT @RussellPetty19: Fourth year @UoDMedicine student Cyril Kocherry presenting his research on brain metastases in Oesophageal cancer a….

Fantastic to see another @onctrainees project published! . The TOURISM study (Treatment Outcomes in UteRIne SarcoMa) was a UK-wide study with the goal of reporting patient characteristics, treatment strategies and outcomes in this rare tumour type. @UoDMedicine @NHSTayside.

RT @BMJOncology: 📣 UK national observational cohort study investigating Tolerance of Anti-cancer Systemic Therapy in the Elderly: the TOAST….

Congratulations @MissHClements! . @UoDMedicine @NHSTayside.

RT @JulveMax: Team UK ESMO football team 🇬🇧🙌🏻.#ESMO2024 @MelanomaPod @cdanicas @DrSapnaPatel @royalmarsdenNHS @DuncanGilbert11 @Adam_Hexter….

RT @UoDMedicine: Cancer tool "unable to accurately predict" toxicity levels in UK patients: new methods to determine which older adults wit….

This study was a monumental effort from the @onctrainees trainees involved - no funding or protected time was received & planning began (led by @HelenDearden3) in 2017 with recruitment over 2 years! . Finally, we must also thank the patients and families who took part. 9/9.

In summary, in a UK pop of older adults receiving 1st line CTx:.➡️ Frailty is prevalent.➡️ ~1/4 develop at least one severe toxicity.➡️ ~1/4 have a hospital admission.➡️ CARG Score was not validated . Importantly patient/clinician perceptions of risk differ significantly!.

Perception of toxicity risk:.➡️ Patients were more likely to think they had a ⬇️ risk than clinicians .➡️ Clinicians were more likely to think patients were at a ⬆️ risk of toxicity.➡️ Overall, there was poor correlation between the clinician & patient perceptions of risk. 7/9.

Toxicity prediction:.➡️ Median CARG score was 6 (range 1–14); 34.3% low risk, 53.2% medium risk & 12.5% high risk.➡️ CARG Score/Grouping did not robustly predict toxicity risk. However:.➡️ CFS 1–3 had significantly fewer G3+ toxicities than CFS of 4+ (19.7% vs 36.4%, p=0.02). 6/9.

314 patients had follow-up data:.➡️ 26.4% required at least one dose delay.➡️ 39.2% did not complete the planned number of cycles. ➡️ 22.3% developed a Grade ≥3 CTCAE toxicity .➡️ 26.8% patients had at least one hospital admission during the study. 5/9.

339 eligible patients were recruited from 19 UK sites:.➡️ Median age 73 years (range 65–92).➡️ 59.1% ECOG PS 1.➡️ Median Rockwood CFS was 3 (range 0–8).➡️ Median G8 was 12 (range 6–16). Only 21 (6.2%) patients had a formal baseline frailty assessment as standard of care. 4/9.

In a UK population, aged >65 recieving 1st line CTx, TOASTIE aimed to:.➡️ Validate the @myCARG Score.➡️ Describe the prevalence of frailty.➡️ Demonstrate feasibility of frailty assessment.➡️ Describe patient and clinician perception of toxicity risk associated with CTx. 3/9.

Alongside the accompanying editorial by @BreastDocUK @nicolobattisti . 2/9.

Delighted to see the @onctrainees UK prospective 'Tolerance Of Anti-cancer Systemic Therapy In the Elderly: The 𝐓𝐎𝐀𝐒𝐓𝐈𝐄 study' published in @BMJOncology. @HelenDearden3 @michaelroweuk2 @DrSallyMartin @SIOGorg @YoungSIOG @siognah @UoDMedicine . 1/9.

Thank you @RussellPetty19 @PeterHall001 Prof Chim Lang @TASC_Research for your support in obtaining the @CSO_Scotland EPD Fellowship. We will investigate the impact of age, co-morbidity & frailty on cancer outcomes in older adults. @UoDMedicine @YoungSIOG @SIOGorg @NHSTayside.

👇Wellcome Trust Multimorbidity PhD opportunity in Geriatric Oncology commencing August 2025 👇. Any questions, please get in touch!. @UoDMedicine @RussellPetty19 @PeterHall001 @YoungSIOG @onctrainees.