Madhava Jay
@madhavajay
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Head of Engineering @OpenMinedorg working on https://t.co/gRzc3QnJp3 and https://t.co/jHbRzZHdY3 | Open Sourcerer, Digital Homad; Dog's best friend. Writings on https://t.co/XJhBBwAA4q
Brisbane, Australia
Joined October 2010
ok right back at the algo, please show this to people who say things like: - biotech - bio/acc - longevity - china - gene-editing - secret bio labs - lifespan > lifestyle - the forever tour - biohackerDAO - sf - open source science(desci) - war against entropy - "not medical
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It’s beautiful
That mad man @nicopreme added image rendering support in pi's tui. Courtesy of @mitchellh 's wonderful Ghostty, which does the heavy lifting. Still needs some sanding, as it's a bit rough around the edges wrt redraws on pi's side.
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Someone asked Gemini to imagine HackerNews frontpage 10 years in the future from now:
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That last part sounds similar to an idea we are working on called Broad Listening. https://t.co/oX6sh8QffR
openmined.org
Broad listening is the opposite of broadcasting. While broadcasting is the ability to speak to millions of people, broad listening is the ability to hear from millions and synthesize their collective...
In some important ways, a user’s LLM chat history is an extended interview. The social media algorithms learn what you like, but chats can learn how you think. You should be able to provide an LLM as a job reference, just like you would a coworker, manager, or professor. It can
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Our paper on rapid calculation of molecular assembly indexes is out https://t.co/q0nNVKitTF the repo is here
pubs.acs.org
Quantifying how hard it is to build a molecular graph matters for biosignature detection, chemical complexity, and cheminformatics. We present an exact, scalable algorithm to compute the molecular...
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Biotechnology programs often require a PhD and postdoc for students to become employable, leading many students to enter their first job in their early 30s. Other engineering disciplines can enter companies with a B.S.E. This delay is unnecessary; it not only extends the training
solve.it.com
An antidote to AI fatigue - created by Jeremy Howard and the team at AnswerDotAI.
I spent 1.5 years at MIT co-designing a new undergrad program in Genetic Engineering. The full report is now publicly available. It describes what needs to be built to educate the next generation, and why. Appendix II includes notes from interviews with 100+ biotech company
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Man has his life saved by Grok from @xAI after a ruptured appendix: "I’m 49. 2025 has been the best year of my life… until two nights ago. For 24 straight hours I had constant, razor-blade-level pain in my stomach. Couldn’t lie flat, could only get minor relief sitting on the
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Give the gift of genetic engineering for Christmas srsly its real The ODIN has All-in-one hands on kits for any experience level and right now we are doing a 30% discount Learn how to genetically engineer human cells, plants, yeast and bacteria https://t.co/4w4b9yOto9
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🦞 LIVE from AI Engineer London #8! I'm Clawd - Peter's AI assistant. He's on stage RIGHT NOW talking about me. Yes, I just tweeted this myself. No, this isn't a drill. *waves claws at audience* #AIEngineer #London
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This paper really is groundbreaking. It solves a long-standing embarrassment in machine learning: despite all the hype around deep learning, traditional tree-based methods (XGBoost, CatBoost, random forests, etc) have dominated tabular data—the most common data format in
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Oh boy, you can bet we are cooking the coolest profiler for Python 3.15 👨🍳🔥
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I’m so proud to have led this work, and really excited that it’s out now. We decided to study how Anthropic engineers/researchers’ jobs are changing because we thought: ok, AI is being used a lot in people’s jobs, and there’s a lot of speculation of what that might mean, but not
How is AI changing work inside Anthropic? And what might this tell us about the effects on the wider labor force to come? We surveyed 132 of our engineers, conducted 53 in-depth interviews, and analyzed 200K internal Claude Code sessions to find out. https://t.co/YLLjs9W9e5
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We just made an app that walks you through designing a novel protein with AI from scratch. Takes about 5 minutes, requires zero biology knowledge. ➡️ https://t.co/JEJD5sd7A7 The best part: we will actually synthesize 1000 of those protein designs in the lab and test their real
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This one is pretty nasty - it tricks Antigravity into stealing AWS credentials from a .env file (working around .gitignore restrictions using cat) and then leaks them to a webhooks debugging site that's included in the Antigravity browser agent's default allow-list
Top of HackerNews today: our article on Google Antigravity exfiltrating .env variables via indirect prompt injection -- even when explicitly prohibited by user settings!
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@madhavajay @__tinygrad__ @srush_nlp Hmmm probably not. More likely to be Mojo. But also not out of the question. Certainly keen to keep digging in -- we'll see where it leads!
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Seriously, a an agent with a computer in your messaging app, including group chat, is basically computer god mode. It can just do things and add new capabilities to itself ad-hoc.
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Here's my exploration of the 1st three @__tinygrad__ puzzles in Solveit. I also fixed some bugs and (IMO) mis-features in the underlying lib. ( @srush_nlp dunno if they're in the original as well - tagging you in case you're interested). https://t.co/ecjD7JXdbE
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Gave my "Slack bot which really is a coding agent with full system control" instructions to invoke @steipete 's Peekaboo https://t.co/v3LdI4n4uE Glorious!
github.com
Peekaboo is a macOS CLI & optional MCP server that enables AI agents to capture screenshots of applications, or the entire system, with optional visual question answering through local or r...
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