Luisa Morales-Nebreda
@luisamnMD
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Physician-Scientist in Pulmonary and Critical Care Medicine @NUFeinbergMed | Immune mechanisms in lung injury and repair
Joined February 2019
Happy to share our work examining lung T cell responses during severe pneumonia—including #COVID19: Huge lift 💪 from The NU SCRIPT Investigators @NM_Lung @NUFeinbergMed. Kudos to @nsmarkov @Ziyou2015 & Karolina Senkow 🧵
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RT @ATS_GG: Our next journal club is on 7 Nov at 4pm ET/1pm PT! "Distinctive Evolution of Alveolar T-cell Responses is Associated with Cli….
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Excited @JulesBass6 visited @NM_Lung and shared her ongoing basic/translational work for our SQLIFTS distinguished scientist lecture series!
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RT @NUFeinbergMed: Northwestern Medicine investigators have identified distinct #TCell responses associated with patient outcomes in unvacc….
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Special thanks to all study participants, our cross-functional SCRIPT clinical and core teams, and @NIAIDFunding SysBio Centers, editors and reviewers at Nature Immunology for supporting this work!.
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We identified that a subset of TCRs generated in response to different pneumonia etiologies associated with survival. Together, we discovered that lung SARS-CoV-2-specific T cells with distinct molecular and specificity profiles are associated with clinical outcomes in #Covid_19
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TCR-seq analysis showed that distinct antigen specificity and magnitude of the response were associated with clinical outcomes, timing of lung sampling and age of patients, revealing a positive association between T cells targeting nonstructural epitopes and COVID-19 severity
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Transcriptional profiling of lung T cells revealed that activation of IFN signaling early during SARS-CoV-2 pneumonia was associated with survival, while upregulation of inflammatory programs driven by NF-κB late during the course of pneumonia was associated with worse outcomes
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We found an enrichment of T cells in the lungs of patients with SARS-CoV-2 pneumonia that correlated with favorable outcomes when compared with other types of pneumonia
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To identify pathogen-specific T cell responses, we integrated cellular and molecular analysis (flow, RNA- and TCR-seq) of 432 serially collected BAL samples with clinical phenotyping of 273 patients with pneumonia
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It is not clear whether the lung T cell response in severe pneumonia is similar across pathogens or whether the cell profiles, gene expression programs and antigen specificity evolve differently over the course of disease.
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RT @immunology_nu: We are excited to partner w/ @FOCISimmunology & present their first Virtual Symposium 9/26 | 10 - 12:30 P.M. CDT. "Trans….
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RT @NUCATSInstitute: KL2 Profile Series: Chiagozie Pickens, MD, MSc, is committed to the implementation of diagnostic excellence in the mov….
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The NU SCRIPT Investigators are happy to share our new work on T cell responses during severe pneumonia!.
A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 . #biorxiv_sysbio.
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RT @CDelaCruzMed: Interested in the biology of acute respiratory infections? We have an exciting program for @GRCBARI2024 + GRS BARI for ea….
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RT @AMcQHMD: Happy to share a little bit of my journey at @NM_Lung @NU_IntMed @NUFeinbergMed 💜
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Congratulations NU PCCM fellowship graduates. We’re very proud of you! @AMcQHMD, Sydney Hyder, Dave Kidd, Romy Lawrence and @KaitlynVitale! @cjschroedl @macwalterMD Espo and @wanderlostlass @NM_Lung !
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Important work from a very talented MD PhD student!.
Happy to share our recently-published literature review authored by myself, NUMSTP colleagues, and @ArdehaliHossein on the impact URM and marginalized identity status has on MD-PhD student experiences and academic outcomes.
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RT @ekaitys: Had an incredible morning at #ATS2023 in the Immunology in Context session with @AJRogers_ICU @TimFlerlage @luisamnMD @AubreeG….
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