Julie Bastarache
@JulesBass6
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Physician, scientist, mom. Basic and translational research on acute lung injury, alveolar capillary barrier. #ARDS #sepsis #CellBiology #PulmCCM
Joined March 2020
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Pinned Tweet
The 5 stages of scientific conference development:
1. No one knows you and you don’t know anyone
2. No one knows you but you know everyone
3. Every one knows you and you know everyone
4. Everyone knows you but you don’t know anyone
5. No one knows you and you don’t know anyone
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If I could give aspiring scientists and trainees one piece of advice it would be this: Find a mentor who cares enough about you to do this 👇
#Mentorship
#AcademicChatter
#PhysicianScientist
#CareerAdvice
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Note to mentors: remember to warn new mentees that this👇is normal. Although I’m totally used to seeing my work come back to me like this (one of my old grants), it can be shocking the first time. I forgot to warn a new grad student and regrettably caused a lot of distress 🤦♀️
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CXR quiz: what’s the diagnosis? The newest generation of MDs may not recognize this. It’s a good example of the desperation of the times and the daring of surgeons.
#MedTwitter
#Pulmonary
#CXR
#HistoryOfMedicine
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CXR quiz: what’s the diagnosis?
This is one of my all time favorite X-rays!
#MedTwitter
#Pulmonary
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Things I’ve learned from being a ICU doctor for 15+ yrs
-getting a good hx takes an hour
-do a full skin exam
-look at rads images before reading the report
-have pts/family bring in actual med bottles
-sometimes the only thing you can offer a pt is your time, give it to them
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What makes a great mentor? Someone who takes the time to do this👇to your grant. This is one of my first attempts at a K08. So thankful that Lorraine Ware took the time to help me become a scientist and who showed me how to be a great mentor.
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Advice to early career scientists: don’t give up!! Here is a timeline of grants I submitted (orange) and grants funded (green). The submitted section is incomplete because I ran out of space. Perseverance pays!!!
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I joined Twitter last week to follow the coronavirus pandemic and have discovered an unexpected benefit-a strong sense of scientific community. So important right now as all of our scientific meetings are cancelled. Thanks guys!
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@visevic
@WUR
Beautiful!! I encourage everyone to read this amazing book. You will never look at trees the same way again!
@PeterWohlleben
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@iamspdwivedi
It’s an old surgical treatment for tuberculosis (Tb) a lung infection also known as “consumption”. Since there were no antibiotics at the time, surgeons would collapse the infected lung and fill the space with balls to “suffocate” the Tb. It’s called Plombage.
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@jfitzgeraldMD
I wish someone had told me:
1. Breastfeeding REALLY hurts for the first week
2. I would still be wearing maternity clothes for months after the baby was born
This knowledge would have saved me a lot of mental anguish. I thought something was wrong with me ☹️
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@BaranTuranMD
It is a form of calcified granuloma post infection but not from tb. This is post histoplasmosis mediastinal granuloma.
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Our lab has a mantra, “Celebrate negative data” so that everyone knows we want rigorous experiments and not the “right” answer. This fosters open communication and reduces stress since we do seem to have a lot of negative data. 🤣 It may not apply to your lab.
#TrustInScience
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Want to know what it’s like to live with end-stage
#COPD
? Take a deep breath in and use that as your starting point, try and breathe on top of that.
I was reminded of this on rounds in the ICU this morning.
#ICU
#PCCM
#MedTwitter
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What does a physician scientist career look like? Here’s my career timeline from fellowship through tenure. Blue=milestones, orange=grants submitted, green=grants funded.
#AcademicChatter
#GrantTips
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Brackish water + cirrhosis = vibrio. All MDs need to burn this into their memory. Thanks for sharing!
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As a research mentor and PI I try to be very deliberate about praising a well done experiment rather than a specific result. I don’t want my lab to think that I’m only excited when an experiment turns out a certain way. Scientific integrity is so important and starts with the PI.
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In the first few years of your scientific career, it’s important to publish early and often. This is my bibliography when I submitted my first R01. Note the absence of “high impact” pubs. Reviewers noted my “excellent productivity.” Publish everything, even “negative” data.
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@OGdukeneurosurg
I wear a white coat (nice thick fabric one with knot buttons) for a few reasons.
1. Pockets. Lots of pockets
2. Keeps me warm
3. Protects my clothes. I work in the ICU->blood, sputum, stool, etc
4. As a female physician, it lets the patients know that I’m their doctor
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Early career scientists: ever wonder why mid career peeps seem less frazzled? It’s not that our To Do lists are shorter. Our secret is that we become comfortable with never for finishing everything on our endless To Do list. Reaching this level of acceptance is a key career skill
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When I became a mom I decided that I would not work at home when the kids were awake so that I could spend time with them. We have dinner as a family every night and I don’t work until after they go to bed. Maybe this means I’ll never have a CSN paper but I’m ok with that.
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Things I’ve learned from being a scientist for 15+ years
-my hypotheses are almost always wrong
-things take 4x longer than expected
-there are many ways to screw up an experiment and I’ve done them all
-a scientist is s professional writer
-science is unexpectedly social
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True confession:
I have a full time nanny. I couldn’t do everything I do w/o help. I know this is not possible for many. I realize I’m privileged. I get so uncomfortable when people say to me “I don’t know how you do it!” I don’t. I have lots of help.
#WomenInSTEM
#WorkingMom
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Advice for those looking for a research mentor: find someone who will encourage you to publish early and often even if in a “low impact” journal. # of pubs early on is so important. A generous mentor is a great mentor.
#AcademicTwitter
#sciencetwitter
#mentorship
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@chungk1031
Only half of what you learn in medical school is true - we just don’t know which half.
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@TheBlondeRN
Nope. They stay in for life. Freaked me out the first time I saw an X-ray like this from one of my patients!
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Advice for early career scientists working on a K (or any CDA): make sure the reviewer can envision what your R01 will look like after the K ends. As reviewers, we discuss that in study section. If we can’t imagine the R, it is difficult to see how you will become independent.
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Early career scientists (esp 🚺) are worried that they are too busy to have children. Couple of thoughts:
-having kids made me WAY more efficient at work
-my kids have never made me feel guilty about working
-I’ll never have a Cell or Nature paper but that’s ok
#AcademicChatter
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Writing good grants is key to research success in an academic environment. I put this together for a recent career development session. Each tip was learned the hard way!!
#GrantWritingTips
#AcademicTwitter
#CareerDevelopment
.
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I hear a lot of my friends/colleagues say that they don’t have time to read. I find that reading (non-work related) makes me a much better writer. After all, being a scientist = being a writer. IMO, “leisure” reading is well worth the time spent.
#AcademicChatter
#CareerAdvice
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Just had a great session with med and grad students about failure. Here’s a compilation of 15 lessons learned in my 17 years as a physician scientist and the “failures” from whence they came.
#CVofFailures
#AcademicTwitter
#WomenInSTEM
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Really important lesson I learned in the ICU that applies to many (all?) situations in work and life:
The time when you least want to walk into a room and have a conversation is the time when you most need to do it.
#MedTwitter
#AcademicTwitter
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Random Grant Writing Tips:
-lead with your strongest Aim
-have preliminary data for each Aim
-make figures large enough for your grandma to see
-try and get a figure/table on every page
-avoid jargon
-don’t neglect the Alt Approaches section
#GrantTips
#AcademicTwitter
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When I was a resident in the ICU I noted several gift baskets in the break room. I said to a nurse
“It’s so nice when a patient we saved sends us a gift basket”
“No” she said “these are from the families of patients who died”
We can make a positive impact even when patients die
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Critical care pearl of the day: there are only two ways to increase oxygenation using the ventilator:
1. Increase FiO2
2. Increase mean airway pressure
That’s it. Every change you make that improves O2 does one of those 2 thinks.
#PCCM
#ICU
#CriticalCare
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Wow! Now I’ve made it! Top 0.1%!!! Who else has made it to the top? 🤣🤣🤣
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A message to early career scientists who won’t get funded this cycle. Don’t give up!! I vividly remember the awful feeling of seeing my unfundable score on my first K08 submission. Fortunately I also vividly remember my mentors encouragement that helped me persevere.
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As scientists, we need to embrace and publish ALL of our data - even if “negative”. It help science in general and also our trainees who often put their heart and soul into those “negative” findings. Submit to
@PLOSONE
@PhysRep
& others (?suggestions)
#ScienceTwitter
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A note to women starting out on science or medicine (or any career, really). If you choose to wait to have kids, you won’t be alone. I am about to turn 49 and have a 1st grader. Hopefully being an older parent has already been normalized but if not, it needs to be.
#womeninSTEM
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The 5 stages of scientific conference development:
👉1. No one knows you and you don’t know anyone
2. No one knows you but you know everyone
3. Every one knows you and you know everyone
4. Everyone knows you but you don’t know anyone
5. No one knows you and you don’t know anyone
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@Pierce_Vasc_Lab
@katiedimartin
I see 2 potential problems with that
1. I’m not always thankful
2. My name’s not Ric
But at this point, I’m willing to try anything. I’ll let you know how it goes.
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Question for people who attend academic or medical conferences:
Do you request meal reimbursement?
I feel guilty about doing it because I’d still be spending money on food even if I wasn’t at a conference. Am I alone on this?
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Someone recently asked me what it was like to be a woman in science and medicine at VUMC. After thinking for a second, I told them that I don’t actually feel like a woman, I don’t even notice my gender. That’s how it should be. Thanks
@VUMCLung
@VUMC_Medicine
#WomenInSTEM
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2023 is an amazing year. Women are leading 7 of the world’s leading respiratory and critical care societies ! Amazing!!
#ATS2023
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All new PIs should follow
@CterminiPhD
for tips as they start their own research group. I’ve enjoyed her
#NewPI
journey! I think us mid and senior career folks should follow her lead and start an
#OldPI
tag where we can share advice and lessons hard learned! Who’s with me??
Just a
#NewPI
posing in the hallway with our newest arrival, the microscope. She really makes the lab feel complete.
#TheLabEdit
I can’t wait to share the beauty of fluorescence microscopy with our team. What should we name the scope?
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So excited to work with my sister on her 1st R01!!!
#SisterPower
!!
@micromindy
@AmyEngevik
@thekengevik
@lisa_bastarache
With a 5-yr $4.3M grant from
@genome_gov
,
@lisa_bastarache
@DMRuderfer
@JoshPetersonMD
@JulesBass6
& team will explore computational solutions to help address the problem of missed/delayed diagnosis for pts w/ rare genetic diseases.
👇
via
@vumchealth
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I’ve seen something I really like in a few grants I’ve looked at lately and I wanted to share:
The first mention of an abbreviation is in bold text. This makes it super easy to go back and find the definition. Very nice. I plan to use it myself.
#GrantTips
#writingtips
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Advice for early career scientists: Your hypothesis doesn’t have to be correct. In fact, the science often gets way more interesting when it’s disproven. Trainees are often worried about stating a hypothesis because it might be wrong. Don’t be!
#TakeAStand
#ScienceTwitter
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I don’t normally post family stuff but this made my day. My 7 year old added an important body part to her worksheet. ❤️❤️❤️
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@DrRicketts1
Actually, it’s from an article. I’m reading a book about past pandemics and the Tb chapter reminded me of this old treatment.
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@AvrahamCooperMD
Bingo! This is the most extreme example of post histo mediastinal granuloma I’ve ever seen and I practice in the histo belt!
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Advice for early career scientists looking for an academic job: make sure you ask about admin support for grants - both pre- and post-award. SO important to have great support. It can significantly impact your career. Thankful for the great people
@VUMCLung
.
#AcademicTwitter
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If I ever become independently wealthy (highly unlikely) I’m going to start a grant program specifically for mid career scientists. We’re too old for the numerous early career opportunities but too young for awards and endowed chairs. A bit of a funding desert.
#AcademicTwitter
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CXR quiz: what’s the diagnosis?
You get to ask one question. The answer will give you the diagnosis.
#Pulmonology
#MedTwitter
Images from Journal of Case Reports
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@MissMicroglia
A rejection does not mean that your paper is not worth publishing, just that it’s not a good fit for that particular journal. Read the reviewer comments as if they were from your mentor, make changes, and submit to the next journal.
#AcademicChatter
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I was fortunate to bump into
@CaulfieldTim
right after his provocative and inspiring talk at
#ATS2023
! His advice was invaluable. To combat misinformation, start small and stay focused on something you are passionate about. Appreciate his generosity!!
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Interested in hearing about Acute Lung Injury models? Come to the
@atscommunity
workshop report
#ATS2022
hear from international experts on the topic! Sunday 15th 10:30-12 room 155. Add it to your calendars now - it’s not in the program
@hskulkarni
@JanetSLee1
@robertpdickson
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Advice for early career scientists: a great way to get your name out there and build your network is by asking questions during conferences. Don’t be afraid to raise your hand on zoom or walk up to the mic in the lecture hall. Introduce yourself first then ask your question.
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This 2+ year hiatus has made me appreciate the absolute necessity of in person conferences. I feel so invigorated being at
@expbio
. I already have so many new ideas. Being together is critical for science!
#ExpBio
@APSPhysiology
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Started signing my emails with:
Regards,
It’s going to be difficult getting used to it. I was using “Best,” which I personally like but that seems to have fallen way out of favor (as I have learned on Twitter).
I’m hoping my career will really take off now 🤞
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Best line in E.T.
“It could be sepsis”
Didn’t notice it when I saw it in the theater in 1982 🤣🤣🤣
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@RebecaAndrade_1
It’s an old surgical treatment for tuberculosis, a lung infection also known as “consumption”. Since there were no antibiotics at the time, surgeons would collapse the infected lung and fill the space with balls to “suffocate” the bacteria. Fortunately we have antibiotics now.
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Proof that the lung is the most beautiful organ!
electron microscope picture of human lung tissue (yellow) with alveoli (tiny air sacs that facilitate gas exchange), a bronchus (blue) and a blood vessel (pink)
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Two days in a row! First images of tissue mass spectrometry on human lung. I feel like I’ve finally made it as a scientist!!
#ScienceTwitter
#AcademicTwitter
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Advice for early career scientists: if you get an email asking if you want to meet with a visiting professor, always say “Yes.” Building a network of people who know your name will pay dividends in the future.
#careeradvice
#ScienceTwitter
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Tip for physician scientists: Be realistic about your research progress while on clinical service. I tell myself that I will get NOTHING done in the lab while on service. Now I feel good if I get anything done rather than feeling bad for not doing enough
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@mightdropout
Serious question, where does all that money go?? Seemed to make more sense when there were actual physical journals to produce, print and distribute. Seems like the charges have gone up rather than down. If anyone can explain, please do so.
#ScienceTwitter
#AcademicPublishing
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Beautifully written piece getting back to science and away from sensationalism.
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Congratulations to my dear friend and colleague, Dr. Carolyn Calfee, on her scientific achievement award! She has transformed the field of
#ARDS
. 🎉🎉
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As much as I would love to aim for a Cell or Nature Medicine paper, I don’t like to hold on to data for a “big” story because it means my trainees can’t publish early and often. Hasn’t diminished the fun of being a scientist or my ability to get grants or tenure.
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The Aims Page is the single most important page of your grant. I’ve written a LOT of grants. Here’s how I write an Aims Page.
#GrantTips
#AcademicChatter
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Is it weird that my scientific fantasy is to do a project with zebrafish? The only problem is that I study acute lung injury. 🤔
Dorsal view of a juvenile
#zebrafish
showing scales and lymphatic system. Credit to
@dancastranova
.
#ZebrafishZunday
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More grant writing advice for K’s: it is unlikely that a content expert will review your grant. The K study sections are diverse. I do basic science in ARDS but review grants on COPD, CF, etc. Keep your language simple. Know your audience.
#GrantTips
#Careeradvice
#MedTwitter
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Woo hoo!!!!!
@sucre_jen
wins the Carol Basbaum Award!! Congratulations!!! I hope some of her brilliance rubs off on me every time she walks past my office!
#ATS2022
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Before kids, I was a SUPER judgmental parent
Then: no cell phones at restaurants,no fast food,no screen time,no acting up in public
3 kids later: cell phones at dinner, pop tarts in am,McD’s for lunch, 6hrs screen time,letting a tantrum “work itself out” in public
#REALITY
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Advice to 1st time grant writers: 1. Start working on your Aims page 3-6 months before it’s due 2. Don’t write the body of the grant until your aims page is perfect 3. Take lots of breaks-put it aside for a week. I did exactly the opposite the first time and really regretted it!
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My goal as an Associate Editor for
@AJPLung
: Make people feel good about their work even when I have to reject it. There’s a place for every rigorous study, it just might not by our journal. We need more positivity in science.
#ScienceTwitter
#AcademicChatter
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I’ve been an associate editor for
@AJPLung
for a little over a year and I have to say I absolutely love when I get to accept a manuscript. I get so excited for the authors! I was not expecting these feel good moments would be part of the job!
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If I could tell new trainees one thing as they are searching for a lab it would be this: The right mentor is SO much more important than the “right” project. So thankful that I received this advice early on! Today I get to run my lab with both my mentor and mentee. So fun!!
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As a working mom it took me a long time to accept my feelings. I was excited to come back to work after each maternity leave, I don’t like doing crafts, I don’t enjoy baking. All of that is ok. I love being a physician-scientist and hope that I’m a good role model for my kids.
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@sjbeckerphd
Another factor is being ok with having a long “To Do” list and still leaving work at the end of the day.
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People applying for K/CDA awards often ask how many papers they need to be competitive. Here are some guidelines
At least:
-1 with your mentor
-1 first author
-1 directly related to the proposed project
-1 in the year leading up to submission
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I don’t know why this bothers me so much but it’s “data are…” not “data is…”
#MedTwitter
#sciencetwitter
#AcademicChatter
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One of the best pieces of advice I ever received was: the time when you most dread going into a patient’s room (to deliver bad news, have a difficult conversation, etc) is the time when you most need to go into a patient’s room.
#medtwitter
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It’s important to think about the figures you want in your research manuscript BEFORE you even do the experiments. I often sketch out what I want to show in each figure/panel when I’m first working on a project. It helps so much with experimental design.
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Trying to secure some unrestricted money for my lab. Wish me luck!
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An under appreciated life skill that comes with age is the ability to NOT stress about a never ending, never completed To Do list. You will never finish everything on the list and that’s ok. Once I reached this level of acceptance, I became much happier and less stressed.
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Yet another use for Parafilm! Giving my loose rings a little bulk so they won’t fall off!
#LifeHacks
for scientists!
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Such a special night with great friends! Tom Martin, Michael Matthay, Carolyn Calfee, Lorraine Ware.
#ATS2022
so happy to be here with such amazing people!!
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