Simon Little Profile
Simon Little

@littleneuro

Followers
598
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Neurologist & Neuroscientist interested in Adaptive Brain Stimulation, Movement, Mood, Motivation, Sleep, Self Regulation, Psychology and Dadding!

San Francisco, CA
Joined April 2018
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@littleneuro
Simon Little
15 days
Grateful to the big team of collaborators including Jeffrey Herron, Ph.D. and @gallantlab who helped made this possible as well as many people within @NeurosurgUCSF, the Weill Institute of Neuroscience and @NIH_NINDS.
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@littleneuro
Simon Little
15 days
This was fully programmed using ML, remotely in patients own homes, addressing the challenges of increasing DBS programming complexity.
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@littleneuro
Simon Little
15 days
Happy to share our latest study led by @TantanBrainMan and our team @UCSF out today in Nature BME! Movement Responsive AI programmed BCI-aDBS improves naturalistic motion and reduces excessive movements at rest in PD.
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@littleneuro
Simon Little
6 months
Happy to be launching this special edition in NPJ Parkinson’s on everything sleep and PD related!
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@littleneuro
Simon Little
7 months
Super happy to share this paper with Lucia Ricciardi and Bart Swinnen and others looking anxiety in PD! Turns out that basal ganglia theta indexes trait anxiety in 3 independent cohorts.
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@littleneuro
Simon Little
11 months
RT @UCSF: 1 million Americans have Parkinson’s disease. UCSF researchers are developing a new treatment, adaptive deep brain stimulation, t….
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@littleneuro
Simon Little
11 months
Incredible resource from the hugely talented Bonaiuto lab. Want to run super high resolution MEG with laminar level hypothesis testing without having to write 10,000 lines of code?! Here’s your toolkit.
@danc_labo
James Bonaiuto
11 months
🚨New laminar MEG toolkit🚨I'm so happy to be at @biomag2024 to announce the release of laMEG, an easy-to-install implementation of the simulations and analyses from our laminar MEG papers AND if you wish you could use SPM from python, keep reading👇🧵
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@littleneuro
Simon Little
11 months
RT @MichaelOkun: Why is DBS still a 'black box' to many folks with Parkinson's and beyond? Great pic from @theNAMedicine @theNASciences by….
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@littleneuro
Simon Little
11 months
Happy to share this preprint completed with @TantanBrainMan and colleagues! Why try and smooth over and ignore movement in adaptive DBS when you can target it directly? All completed remotely in our patients home with a fully automated end-to-end programming pipeline….
@TantanBrainMan
Tanner Dixon
11 months
Excited to share a preprint of work done together with folks from UCSF (@littleneuro), UC Berkeley, and U of Washington, using neural decoding and adaptive DBS to selectively amplify movement when intended and reduce dyskinesia when it isn't.
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@littleneuro
Simon Little
11 months
@CarinaOehrn @scernera1 @LaurenHHammer Come join our team:
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@littleneuro
Simon Little
11 months
Amazing work by our team and particularly our postdoctoral scholars!.@CarinaOehrn.@scernera1.@LaurenHHammer.
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@littleneuro
Simon Little
11 months
For a deeper look:
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@littleneuro
Simon Little
11 months
Excited to share here the story of Shawn, a patient in our adaptive DBS study -
@UCSF
UC San Francisco
11 months
Meet Shawn, a former pro skateboarder diagnosed with Parkinson's nine years ago. With adaptive deep brain stimulation, a personalized algorithm adjusts his treatment as symptoms change. @littleneuro @NeurosurgUCSF
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@littleneuro
Simon Little
11 months
So proud of our 3 female first co-authors who led this project @CarinaOehrn, @scernera1 & @LaurenHHammer along with friend and co-senior author Philip Starr. Adaptive DBS for Parkinson's is out of the lab and into the real-world!.
@CarinaOehrn
Carina Oehrn
11 months
The most creative, intense, and rewarding project I’ve ever worked on! Now out @NatureMedicine. Real-world blinded adaptive DBS halves time with motor symptoms and improves quality of life in Parkinson’s disease. With the amazing @scernera1 @LaurenHHammer @littleneuro Philip.
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@littleneuro
Simon Little
1 year
RT @colinwhoy: Our study on reward and effort signals in PFC theta and basal ganglia beta is now out in @PNASNews! Big thanks to the team (….
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@littleneuro
Simon Little
1 year
RT @UCSFHospitals: Video-based machine learning can help clinicians predict motor impairment severity for patients w/ #ParkinsonsDisease, a….
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@littleneuro
Simon Little
1 year
RT @MichaelOkun: There are 17 DBS and neuromodulation articles now published in Volume IV @DBSThinkTank @FrontNeurosci and the editorial i….
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@littleneuro
Simon Little
1 year
Super happy to share some work by an awesome team led by @fahim_naruto investigating NREM sleep dysfunction in PD. Turns out that beta burst aren’t just naughty in the daytime…
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@littleneuro
Simon Little
1 year
RT @MartaSanLucian1: 🧠 Exciting News! Thrilled to announce the commencement of our new study exploring cerebellar deep brain stimulation to….
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@littleneuro
Simon Little
2 years
RT @crozSciTech: Excited to share this paper using new neurotech and explainable AI to advance DBS for treatment resistant #depression (TRD….
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