Simon Little
@littleneuro
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Neurologist & Neuroscientist interested in Adaptive Brain Stimulation, Movement, Mood, Motivation, Sleep, Self Regulation, Psychology and Dadding!
San Francisco, CA
Joined April 2018
Grateful to the big team of collaborators including Jeffrey Herron, Ph.D. and @gallantlab who helped made this possible as well as many people within @NeurosurgUCSF, the Weill Institute of Neuroscience and @NIH_NINDS.
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This was fully programmed using ML, remotely in patients own homes, addressing the challenges of increasing DBS programming complexity.
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Happy to share our latest study led by @TantanBrainMan and our team @UCSF out today in Nature BME! Movement Responsive AI programmed BCI-aDBS improves naturalistic motion and reduces excessive movements at rest in PD.
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Happy to be launching this special edition in NPJ Parkinson’s on everything sleep and PD related!
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Super happy to share this paper with Lucia Ricciardi and Bart Swinnen and others looking anxiety in PD! Turns out that basal ganglia theta indexes trait anxiety in 3 independent cohorts.
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RT @UCSF: 1 million Americans have Parkinson’s disease. UCSF researchers are developing a new treatment, adaptive deep brain stimulation, t….
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Incredible resource from the hugely talented Bonaiuto lab. Want to run super high resolution MEG with laminar level hypothesis testing without having to write 10,000 lines of code?! Here’s your toolkit.
🚨New laminar MEG toolkit🚨I'm so happy to be at @biomag2024 to announce the release of laMEG, an easy-to-install implementation of the simulations and analyses from our laminar MEG papers AND if you wish you could use SPM from python, keep reading👇🧵
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RT @MichaelOkun: Why is DBS still a 'black box' to many folks with Parkinson's and beyond? Great pic from @theNAMedicine @theNASciences by….
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Happy to share this preprint completed with @TantanBrainMan and colleagues! Why try and smooth over and ignore movement in adaptive DBS when you can target it directly? All completed remotely in our patients home with a fully automated end-to-end programming pipeline….
Excited to share a preprint of work done together with folks from UCSF (@littleneuro), UC Berkeley, and U of Washington, using neural decoding and adaptive DBS to selectively amplify movement when intended and reduce dyskinesia when it isn't.
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Amazing work by our team and particularly our postdoctoral scholars!.@CarinaOehrn.@scernera1.@LaurenHHammer.
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Excited to share here the story of Shawn, a patient in our adaptive DBS study -
Meet Shawn, a former pro skateboarder diagnosed with Parkinson's nine years ago. With adaptive deep brain stimulation, a personalized algorithm adjusts his treatment as symptoms change. @littleneuro @NeurosurgUCSF
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So proud of our 3 female first co-authors who led this project @CarinaOehrn, @scernera1 & @LaurenHHammer along with friend and co-senior author Philip Starr. Adaptive DBS for Parkinson's is out of the lab and into the real-world!.
The most creative, intense, and rewarding project I’ve ever worked on! Now out @NatureMedicine. Real-world blinded adaptive DBS halves time with motor symptoms and improves quality of life in Parkinson’s disease. With the amazing @scernera1 @LaurenHHammer @littleneuro Philip.
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RT @colinwhoy: Our study on reward and effort signals in PFC theta and basal ganglia beta is now out in @PNASNews! Big thanks to the team (….
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RT @UCSFHospitals: Video-based machine learning can help clinicians predict motor impairment severity for patients w/ #ParkinsonsDisease, a….
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RT @MichaelOkun: There are 17 DBS and neuromodulation articles now published in Volume IV @DBSThinkTank @FrontNeurosci and the editorial i….
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Super happy to share some work by an awesome team led by @fahim_naruto investigating NREM sleep dysfunction in PD. Turns out that beta burst aren’t just naughty in the daytime…
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RT @MartaSanLucian1: 🧠 Exciting News! Thrilled to announce the commencement of our new study exploring cerebellar deep brain stimulation to….
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RT @crozSciTech: Excited to share this paper using new neurotech and explainable AI to advance DBS for treatment resistant #depression (TRD….
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