Passionate about single-cell method development? 🔬 Join our lab as a Postdoctoral Fellow at @UBC and help uncover androgen receptor enhancer mechanisms in prostate cancer. https://t.co/uKpGrgt6ML

Congrats to this year’s recipients of the VCHRI Top Graduating Doctoral Student & Rising Star Awards! 🎉 Learn how these up-and-coming research leaders are contributing to the community: https://t.co/FAF211BY3d

I am extremely honored to receive @WellcomeTrust Early Career Award - the first-ever given to @kocuniversity and Türkiye 🇹🇷! Grateful to my mentors @tugbabagcionder and @Tamer_Onder.It was pleasure working w/@berilesin_ and excited for what’s ahead w/@merdemercann! #WellcomeTrust

Huge congratulations to @ozlemyedier for receiving the early career award from @wellcometrust to further explore the mechanisms behind epigenetic regulation of cell cycle. I wish her and @Tbo_Lab members success in this exciting project👏 @kocuniversity @_KUTTAM_

Check out our bioRxiv preprint summarizing our work on AR-V7 condensates, their role in activating a specific gene signature, and enhancing its expression in CRPC models. This work, led by post-doctoral trainee @ShabnamMassah, benefited greatly from co-authors and collaborators.

VPC is thrilled for the launch of the Mohseni Institute of Urologic Sciences! This significant leap forward will foster innovation and enhance translational research for many urologic conditions to positively impact patients. https://t.co/30vWpc6axl @VCHResearch @VCHhealthcare

Core facilities are truly one of the most undervalued assets in an academic institution. They are often treated as also rans, staffed by non tenured faculty with little leeway, and given an exceedingly short runway to become profitable. In an age of shrinking lab sizes and

@f_hach, @dogancan, @AdelmanLab and Matt Freedman

@CFCE_DanaFarber Deeply grateful to our amazing collaborators who brought this research to life! From data generation to analysis, everyone’s unique expertise was essential. This work shows what team science can accomplish when we come together with a shared goal to improve cancer understanding!

@CFCE_DanaFarber This dominant CRE model provides a new framework for understanding nuclear receptor gene transcription and can help guide treatments that target AR pathways. Full study here https://t.co/LozFmiNyni (5/5) #ProstateCancer #AR

@CFCE_DanaFarber Our key takeaway: gene expression is influenced by the frequency of contacts between AR-bound enhancers and target promoters. In this “unbalanced multi-enhancer model,” enhancers vary in impact, with those in frequent contact having the strongest gene activation effect. (4/5)

@CFCE_DanaFarber Interestingly, we showed that AR binding doesn’t create new chromatin loops but instead strengthens contact within pre-existing loops. AR increases the frequency of interactions between specific CREs and target promoters, enhancing the potential for gene activation. (3/5)

@CFCE_DanaFarber AR binding initiates changes in epigenetic marks at CREs without directly altering gene expression. It’s a multi-step process, where AR induces chromatin modification independent of transcription. (2/5) #Chromatin #Transcription

🧵In collaboration with the twitterless Matt Freedman @CFCE_DanaFarber we showed that AR binds to thousands of cis-regulatory elements across the genome, which loop to target gene promoters, yet not all CREs contribute equally to gene expression. (1/5)

How does AR activation affect gene expression? Our new paper shows it’s less about creating new loops and more about amplifying contact frequency in existing ones. Explore in @NatureComms ( https://t.co/LozFmiNyni) Tweetorial below: #AR #Epigenetics #prostatecancer

So excited to be part of the Girls and STEAM summit @scienceworldca today! We are ready to meet our potential future scientists soon! #STEAMForAll #FutureInnovators #DiversityInSTEAM #GirlsInSteam #StrongSmartBold #ScienceWorldVancouver #ScienceWorldca

VGH & UBC Hospital Foundation achieves remarkable milestone, collecting a staggering $65 million for urologic sciences in their most successful campaign yet. Click below to read more. https://t.co/2lROiyiANq

We are thrilled to launch our Urologic Sciences campaign, in collaboration with @VanProstateCtr and @VCHhealthcare, with the goal of raising $35M to bring improved urologic care to British Columbians. Together, we are transforming health care. https://t.co/ikqKGJSVaQ

Recently published: authors from @Zwartlab_NKI analyse the role of #AndrogenReceptor chromatin binding #heterogeneity in #ProstateCancer clinical outcomes, metastasis and relapse #CancerResearch #Epigenetics @natrescancer https://t.co/xa0DUeMh0w

wow, that was one of my actual nightmares @OpenAI