ManuelMuellerLab
@lab_mueller
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Sir Henry Dale Fellow, King's College London. Interested in proteins and their post-translational modifications.
London
Joined September 2019
Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging | Journal of the American Chemical Society @KingsCollegeLon
https://t.co/vhr8vqC4sw
pubs.acs.org
Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is the formation of the β-linked isomer l-isoaspartic acid (isoAsp) from...
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Congratulations co-1st authors @_TianzeZhang & Luis Guerra @kclchemistry and great collaboration with Iana @Beatfierz and Jon.
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We chemically synthesized old histones containing an isoAspartate residue to measure the impact of aging on chromatin integrity. We found that chromatin is surprisingly tolerant of this particular form of wear-and-tear, although local perturbations were observed.
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Thrilled to announce our group's latest paper in @J_A_C_S: Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging | Journal of the American Chemical Society
pubs.acs.org
Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is the formation of the β-linked isomer l-isoaspartic acid (isoAsp) from...
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Check out this fully funded PhD studentship on peptidomimetics available in the Wilson group.
findaphd.com
PhD Project - Peptidomimetic Inhibitors of Protein-Protein Interactions – A Sustainable Approach at University of Birmingham, listed on FindAPhD.com
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I have an AstraZeneca-funded PhD position available (4 years), based in my lab (School of Chemistry, University of Nottingham); start date Oct 2025! Traceless Chemoenzymatic Peptide Synthesis Application deadline: 6 Jan 2025. Get in touch!!! https://t.co/Iox6KyotpK
findaphd.com
PhD Project - Traceless Chemoenzymatic Peptide Synthesis at University of Nottingham, listed on FindAPhD.com
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Come and join my group @TheCrick - we have a PhD https://t.co/sgs0HAccNJ in metal-peptidic cages and high affinity binders, and will advertise a 3 year PDRA in December for a Chemical Biologist with synthetic and cell work experience. Email if interested, retweets appreciated!
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Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis | Journal of the American Chemical Society @kclchemistry @KingsCollegeLon #Kinetic #Resolution #Epimeric #Proteins #Stereoselective #Chemical #Mutagenesis
pubs.acs.org
Chemical mutagenesis via dehydroalanine (Dha) is a powerful method to tailor protein structure and function, allowing the site-specific installation of post-translational modifications and non-natu...
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@J_A_C_S Led by PhD student Guljannat, we introduced a kinetic resolution step to dehydroalanine chemistry. By cleaving the D-amino acid-containing isomer with a D-peptidase, we combine the stereoselectivity of enzymes with the broad scope of chemo-selective Dha functionalisation.
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Thrilled to highlight our work on chemoenzymatic protein modification, recently published in @J_A_C_S : Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis | Journal of the American Chemical Society ( https://t.co/IZ2sS6i4m6)
acs.org
ACS is one of the world’s largest scientific societies and the premier home of chemistry professionals. Find career opportunities, educational resources, professional development, and much more.
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A new scholarship is available to next year's MRes Chemistry students - apply by 31 August. The Mackenzie Family Scholarship established in the memory of Mr F.H. Mackenzie is a prestigious award covering a £22,000 stipend ⚗️ Find out more 🔗⬇️ https://t.co/RDSxMTOtiF
kcl.ac.uk
The Mackenzie Family is proud to establish The Mackenzie Family Scholarship in memory of Mr. F.H. Mackenzie. This prestigious award will cover £22,000 in the form of a stipend for the awardee.
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Excited about engineering powerful biocatalysts? Check out the open PhD position in my group! 👉 https://t.co/yvqlyrw2zl Please spread the word!🇨🇭🏔️🧪🌿☀️ @NCCR_Catalysis @ZHAW Photo: ZHAW Wädenswil / Frank Brüderli
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Late breaking PhD project to work with me and Charlie on mass spec crosslinking in heart disease! To start by Jan 2025. UK fees only, apply by 9th August.
Fully-funded EPSRC PhD opportunity @UoL_LICAMM @AstburyCentre developing live-cell chemical cross linking methods to study myosin folding and disease with myself and @MWrightLab
https://t.co/IdpFD366DB apply by 9th August
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🌟 Join Our Team! 🌟 We're seeking a talented #postdoc to join us @kclchemistry! Come and explore membraneless organelles, molecular conformations, and enzyme activity with us. 3-year post. Deadline extended to June 30. https://t.co/YOb8RzMiDr
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Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases | Journal of the American Chemical Society @KingsCollegeLon #Peptide #Cyclization #Modular #Logic #Nonribosomal #Synthetases
pubs.acs.org
Nonribosomal cyclic peptides (NRcPs) are structurally complex natural products and a vital pool of therapeutics, particularly antibiotics. Their structural diversity arises from the ability of the...
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Interested in finding out how aldehydes cause ageing? Check out this exciting new PhD opportunity in the Hopkinson Group. https://t.co/yZwYn9RxTI DEADLINE = 23rd May 2024. You can apply directly here: https://t.co/e5Jlvs3yL0
le.ac.uk
The Midlands Integrative Biosciences (Doctoral) Training Partnership (MIBTP) is a BBSRC funded doctoral training partnership between University of Warwick, University of Birmingham, University of...
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We are hiring! We look for Postdocs in the field of biophysics / chemical biology of gene regulation within a context of a SNSF Advanced Grant starting in 2024! More details here:
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Make sure to get your applications in by 3rd of March if you are interested in joining us through this fully funded studentship opportunity with @KawamuraGroup
@SciencesNCL @ChemistryNCL @DurhamChemistry
📣 Applications now open for a funded #PhD #chemicalbiology #cyclicpeptides. Exciting opportunity for doctoral research with the Kawamura Research Group and @MosmedC at Newcastle Uni @ChemistryNCL, in collaboration with @novonordisk. More information: https://t.co/KhgR8u9kQC
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4-year studentship available in my lab at @kclchemistry working at the interface of fundamental synthetic biology and therapeutic biotechnology development - come & join me in the XNA world! Please RT https://t.co/wFpGZlRQ23
findaphd.com
PhD Project - Chemical evolution of artificial oligonucleotide catalysts for ultra-specific RNA detection and knockdown at King’s College London, listed on FindAPhD.com
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