Karl Heilbron
@karlheilbron
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Joined October 2015
Many drug targets in ongoing Parkinson's disease clinical trials have strong genetic links. We prioritized PD GWAS genes that may represent our next-best candidates for developing disease-modifying therapeutics. https://t.co/rmPCPgAYsi
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Tools that predict the causal genes in GWAS loci are too complex! Many use XGBoost models with >45 features (i.e. L2G, Ei). CALDERA achieves better performance despite using LASSO regression and only 12 features. This makes it much easier to understand why a gene was chosen.
Simplifying causal gene identification in GWAS loci https://t.co/3cGfDEIESW
#medRxiv
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We took another shot at prioritizing genes responsible for schizophrenia through novel methods based on the latest @PGCgenetics GWAS. I had a great time working on this project and am proud of what came out of it.
Identifying drug targets for schizophrenia through gene prioritization https://t.co/pCmbiTbvtM
#medRxiv
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Are you interested in joining 23andMe’s Postdocs Program? We are looking for recent Ph.D. graduates for many new positions Learn more about the positions and the research areas of interest #postdoc #postdocjobs #ASHGTrainee
research.23andme.com
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How do spouses' sleep patterns interact? Using data on up to 175k spouse-pairs in UK Biobank and 23andMe, we investigated correlations between a number of self-reported and accelerometer-assessed sleep traits
Correlations in sleeping patterns and circadian preference between spouses https://t.co/USTHzKzRLk
#medRxiv
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Good brain health is something we need to promote throughout life. @TBHTimeMatters are very pleased to be joining @AlzResearchUK as signatories of the Brain Health Consensus Statement you can find out more here: https://t.co/7mnl7AoBmP
#brainhealth
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We are delighted to share our full presentation from @GasteinForum's #EHFG2021 conference: Brain Health - rising to the challenge of a forgotten pandemic. You watch it in full and read/download our conference summary report on our website: https://t.co/lRG3GpJvSc
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Check out our latest MR paper for PD! Big thanks to the whole team: @predictPD @preventiveneur1 @sarabandres1 @cornelisblauw @mike_nalls @SingletonNeuro @mendel_random, and the Twitterless
Using a huge amount of @23andMeResearch data, we showed the strongest causal evidence to date that smoking has a protective effect on PD risk 1/n Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study
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Want to donate to the Michael J. Fox Foundation and have your donation matched by 23andMe? I'll be running in the Bay Area Fox Trot on Sunday and you can donate to my page!:
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Latest #IPDGC paper Age of onset GWAS in #parkinson disease identifying interesting links to disease onset for genes #SNCA #TMEM175 #GBA but not for MAPT @pdgenetics @mike_nalls @SingletonNeuro @karlheilbron @cornelisblauw @23andMeResearch @MichaelJFoxOrg
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Check this out!! Our latest PD GWAS is online!!! #META5 #GWAS #parkinson #manynewloci #pdgenetics Big thanks to all collaborators and people involved!! including @23andMe, @MichaelJFoxOrg, @NIH and many others! https://t.co/0kJ8QM1ANC
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My blog post on the 'The Parkinson's Phenome' by @karlheilbron from @23andMeResearch
https://t.co/HDYJjxsnvy
@rnrees @DrAnnaNagy @MDC_IoN_UCL @CureParkinsonsT @ParkinsonsUK
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My latest work w/ @23andMeResearch @predictPD on the Parkinson's disease phenome! Associations between PD and 840 survey-based phenotypes. Replicated 32 known associations and highlighted some potential risk factors (migraine, OCD, allergies, anemia). https://t.co/o6iejxgcBt
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Here's an article summarizing the "Microbiome and Intellectual Property" panel discussion at the SF Microbiome Meetup on 2/22/2018
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Cool article on an ultra quantified-selfer https://t.co/FfiD2JwjyZ
#quantifiedself
statnews.com
When he needed surgery for a blocked colon, internet pioneer Larry Smarr designed a 3-D model of his innards to guide the doctor through every kink.
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My very first tweet: @AlvSanMillan has started an awesome new research group, check it out (pbelab.es)!
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