@OmarRawi89 Many thanks to our experts and author 🙌 #ESHREjc

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Q4: #ESHREjc Until prospective data arrive, what’s a proportionate counseling message for TTC/IVF patients needing analgesia, what alternatives, what timing advice, and how to avoid over-restriction that drives unsafe NSAID substitution? @ESHRE

Q3 #ESHREjc Given emerging evidence of sperm-borne epigenetic and RNA cargo effects on early development, should we test whether paternal acetaminophen use around conception affects embryo dynamics/implantation & how would we design feasible human& animal studies? #ESHRE

@juanjo_fraire @OmarRawi89 @ESHRE @juliauraji @AttilioDGM7 @GLiperis @DKalaitzopoulos @Saara_riibeiro @NoemiSalme30386 We have for example also shown the effect in primary human granulosa cells with a concurrent decrease in AMH levels in women

Q4: #ESHREjc Until prospective data arrive, what’s a proportionate counseling message for TTC/IVF patients needing analgesia, what alternatives, what timing advice, and how to avoid over-restriction that drives unsafe NSAID substitution? @ESHRE

Q3 #ESHREjc Given emerging evidence of sperm-borne epigenetic and RNA cargo effects on early development, should we test whether paternal acetaminophen use around conception affects embryo dynamics/implantation & how would we design feasible human& animal studies? #ESHRE

@juanjo_fraire @AttilioDGM7 @ESHRE We suggest that the patient and the physician in collaboration decide whether analgesia is necessary and if so, which medication, dose and treatment regime to implement. APAP is a true medication with side effects as all other medications.

@juanjo_fraire @AttilioDGM7 @ESHRE Yeah, totally agree. The preconception, conception, and early implantation phases are super crucial. It's worth encouraging women to make healthy choices and to find ways to avoid anything that might harm the little one or a woman herself, even when it's challenging.

@juanjo_fraire @AttilioDGM7 @ESHRE Our APAP data highlights the need to be cautious for patients trying to become pregnant. There are, however, at the moment no other alternative to APAP when it comes to maternal fever and pain management during pregnancy.

@OmarRawi89 @NoemiSalme30386 @Saara_riibeiro @FabrizzioHorta @juanjo_fraire @GLiperis @atylio @DKalaitzopoulos @juliauraji @OmarRawi89 will be the lead moderator of this #ESHREjc – thank you Omar, the floor is all yours 😊

🚨Q1 #ESHREjc The study finds that APAP delays cleavage-stage divisions, while blastocysts keep total cells but show reduced ICM and DNA synthesis. What do these stage-specific vulnerabilities imply for implantation and embryo competence? @ESHRE

Welcome to this month's #ESHREjc moderators 🙌 Have fun! @OmarRawi89 @NoemiSalme30386 @Saara_riibeiro @FabrizzioHorta