Josh Knowles
@joshuawknowles
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Assoc. Professor Cardiovascular Medicine, Stanford and Vice Chair, The Family Heart Foundation
Stanford, CA
Joined September 2014
A tremendous honor to be named the Gerald M. Reaven, MD Professor of Endocrinology @StanfordMed. The 'Father of Insulin Resistance,' Dr. Reaven was a true legend in Endocrinology. I'll always remember how he welcomed me to @StanfordEndo with stories of science and the Division.
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Elevated remnant cholesterol remains a likely cause of ASCVD in diabetes. Remnant cholesterol-lowering therapies should also lower apoB levels to reduce risk of ASCVD: https://t.co/Pbn5TXVZp8 Risk of ASCVD in diabetes in the Copenhagen General Population Study:
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@FamilyHeartFdn @SethJBaumMD @JohnClymer @jantonioglopez @joshuawknowles @ABCardio1 @NatForumHDSP @NationalMedAssn @NHMAmd @blkhlth @BHMinfo
Every year, we dedicate #FHAwarenessDay to getting the word out about this treatable genetic condition. Before we begin, tag a colleague, friend, or organization that you think should hear this conversation. #KnowFH
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@DrM_ODonoghue had led key trials on Lp(a) #FHSummit24 📍may require significant ⤵️ in Lp(a) to get benefit but trials are ongoing 📍siRNA class: longer duration & had ⤵️⤵️ >80% of Lp(a)- dose dependent. (95%⤵️ with olpasiran!) 📍1 year off Tx: 40-50%⤵️ Lp(a) with Olp.
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#FamilyHeartSummit24 Such a great presentation by @DrM_ODonoghue on therapies in development for Lp(a)! Exciting to see the programs from @Novartis @Amgen @EliLillyandCo & @SilenceTheraPlc.🙏🏻 #KnowLpa
@FamilyHeartFdn @MassGenBrigham @joshuawknowles @jantonioglopez @SethJBaumMD
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Dr. Steve Nissen #FHSummit24
#CvPrev #CardioTwitter 🚨🚨🚨We are failing patients🚨🚨🚨 🚨🚨🚨After 3 decades our practice pattern is the same It started in the 1970’s with the Cholesterol Skeptics…& now just stronger despite all the evidence #CVPrev #CardioTwitter
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#FamilyHeartSummit24 Wonderful keynote by Dr Steve Nissen from @ClevelandClinic at the @FamilyHeartFdn Summit! Really superb review of lessons learned!! “Our guidelines are 10-15 behind the science”. Amen! @joshuawknowles @SethJBaumMD @kcferdmd
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#FamilyHeartSummit2024 @hsbhatia discussing why Lp(a) is actionable today! Valuable way to refine risk and intensify prevention strategies. Genetics is not destiny.
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Social media can both help and harm our patients. We need to be there to combat misinformation #FamilyHeartSummit24 #FHSummit24 #KnowFH
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@DrHeatherJohn presenting on misinformation that affects our #FH patients #FHSummit24 🫀 Misinformation comes from many sources 🫀most especially true for treating LDL/ Cholesterol: we have the evidence and yet the myths appear in our clinics everyday 🫀it is not just BOTs
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The patients’ voice always matters. #KnowFH #FHSummit24 Elevated LDL in a child is NOT because of too many cupcakes @FamilyHeartFdn
#FH means checking the whole family #cascadescreening
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@kcferdmd presenting the @FamilHeartFdn database which shows: 📍 despite dx of #FH: 30% on noTx 📍 61% w/ LDL>70 📍Only 13/100 adequately Tx 📍disparities in management of FH persist: worse control in women, young & Black 📍adherence reflects SDOH & access 🚨WE MUST DO BETTER!
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THE @NMHheartdoc discuss if we are making progress in ⤵️ disparities in Healthcare 40 years post Heckler Report: NO WE HAVE NOT! 🫀Ms Heckler-secretary HHS called disparities an affront to 🇺🇸 ideals 🫀Need to ⤵️ bias: Bias is REAL 🫀diversity=Inclusive Excellence #FHSummit24
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@CBallantyneMD discusses advances on nonstatin Tx at #FHSummit24 ♥️Look at how many LDL⤵️ Tx we have! How far we have come! ♥️ Guidelines & Quality measures necessary to help get patients LDL controlled: optimal LDL goals will help us “get to goal” ♥️ Lp(a) new target now
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@dramitkhera #FHSummit24
#FINDFH #KnowFH 🧪 FIND FH machine-learning algorithm: validated w/ 87% accuracy in national database 🧪incomplete data affects accuracy 🧪accuracy does not =actionable: we can still reach out to patients identified 🧪Identification is just 1st step
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@FaRodriguezMD #FHSummit24 discusses AI to improve Health Equity 🫀CAC useful but access often limited by 💰 🫀AI to identify Calcification on any chest CT makes it more accessible & more equitable 🫀over half started statin when notified
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#FamilyHeartSummit24 Not able to make it to Dallas for the @FamilyHeartFdn Global Summit? ✅ out @HCPLiveNews for live meeting coverage! https://t.co/kT0gWkZrEW
@KAWilemon @joshuawknowles @CBallantyneMD @FaRodriguezMD @SuzyKaye @DrMarthaGulati @ASPCardio @nationallipid @ABCardio1
hcplive.com
Family Heart Global Summit | Conference | HCPLive is a clinical news and information portal, offering physicians specialty and disease-specific resources, conference coverage, and interviews.
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10 years of #Familyheart24 - so much accomplished - Creates (2) ICD-10 codes / 6k enrolled registry / 230 ambassadors / 650 HCPs on @FamilyHeartFdn map / consensus statement - and so much more.
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#FamilyHeartSummit24 @lab_hobbs Dr. Helen Hobbs presenting her early work on FH which led her to our French Canadians leading to greater understanding of the genetic mutation that is so common in my country in Quebec 🇨🇦 Further work spread to more diverse popln #FHSummit24
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