Irving Ling
@irvingling
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clinician-scientist in healthcare / medical director in translational medicine
Boston, MA
Joined April 2009
Our paper @TSS_Lab @saukaspengler defining regulatory landscape and associated GRNs in the vagal neural crest is out. See thread below.
nature.com
Nature Cell Biology - Ling and Sauka-Spengler reveal chromatin and transcriptional landscapes that regulate the early specification of vagal neural crest cells during the development of the enteric...
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RT @saukaspengler: I am excited to share this beautiful work led by @Ruth_Y_Williams with @GunesTaylor, @irvingling, @ivanferrreira, et al….
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RT @saukaspengler: "Chromatin remodeller Chd7 is developmentally regulated in the neural crest by tissue-specific transcription factors" @T….
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RT @RuthWilliamsOx: Our latest work showing neural crest-specific regulation of the chromatin remodeler, Chd7, involved in CHARGE syndrome,….
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RT @LukMartyna: Getting antibodies for ChIP-seq for some species can be a real challenge! We solved the problem by using tissue-specific bi….
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Great paper from Kulesa lab! More people recognizing that bonafide NCC migratory markers may not encompass all NCC.@ScienceStowers | We showed Ednrb being a good marker too .@saukaspengler @TSS_Lab.
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RT @simoesfili: I'm very happy to share our latest @TSS_Lab @GroupRiley work looking at the functional diversity of epicardial subpopulatio….
cell.com
Weinberger et al. identify three cell subpopulations with unique gene expression signatures and patterns in the developing zebrafish epicardium. These epicardial subpopulations fulfill distinct...
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RT @saukaspengler: I am delighted to share our most recent work defining functional heterogeneity of the developing epicardium - a fantasti….
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Beautiful.
At @Dev_journal we love cardiac development. For #ValentinesDay, here's a 2018 cover featuring 25 mouse hearts, some broken, from Daylon James and colleagues.
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RT @MaraArtibani: Check out our new paper on Fallopian tube single-cell sequencing and #ovarian #cancer classification, bringing us a step….
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RT @simoesfili: I'm so excited to share our latest work where we show macrophages directly contributing collagen to scar formation in zebra….
nature.com
Nature Communications - Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an...
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RT @saukaspengler: I am delighted to share our latest @TSS_Lab study, a great collaborative effort with @GroupRiley and Choudhury lab, spea….
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RT @OdedRechavi: “It took me years to find a post doc that will agree to work on this project”
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RT @Shelby_A_Blythe: The Blythe Lab is hiring one (or more) postdocs! Do you want to measure how chromatin states change over time? Do you….
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RT @TSS_Lab: Impressive work by @irvingling and @saukaspengler @MRC_WIMM @RDMOxford showing global dissection of regulators controlling ent….
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3. We deconstruct three global VNC Gene Regulatory Networks yielding new insights into neural crest developmental biology and providing a roadmap to future studies linking non-coding regulatory mutations to enteric neuropathies.
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2. This mechanism is controlled by distinct regulatory cores marked by the presence or absence of Foxd3, involving either Sox10/TFAP2 or SoxB/Hbox/bHLH factors.
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1. Nicole LeDourin described a degree of Vagal Neural Crest predetermination almost 5 decades ago. We now show that the VNC chromatin landscape is shaped very early at the onset of NC delamination, and defines distinct neural, neuronal and mesenchymal lineages within the ENS.
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