Derek Abbott
@inflammgenetics
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Cecil and Ida Green Chair of Immunology and Genomic Medicine. National Jewish Health. Physician Scientist target hunting in inflammation. Views are my own.
Denver CO
Joined May 2013
RT @BWFUND: Application now open: Career Awards for Medical Scientists (CAMS) is a highly competitive program that provides $700,000 awards….
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Our faculty search is now live at National Jewish Health. We are recruiting all ranks - strong startup packages and great colleagues!.
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RT @BWFUND: Application now open: Career Awards for Medical Scientists (CAMS) is a highly competitive program that provides $700,000 awards….
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Additionally, we will be starting faculty recruitment. Search will be lead by Lilliana Radosevich - details to follow, but strong startup packages with outstanding colleagues in a great city! 2/2.
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With the lab moving to National Jewish Health in Denver, CO, we are recruiting students, post-docs and technicians. Formal positions are posted, but please reach out with inquiries! 1/2.
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RT @slavov_n: This rate of validation suggests that affinity reagents such as antibodies should be considered non-specific until proven oth….
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It does not seem possible that this girl is 23 years old today. Happy birthday Annabelle! @annabelleabbott
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This leads to the obvious hypothesis that this signaling axis helps inflammasome activation couple innate-to-adaptive immune coupling by regulating amplitude and duration of cytokine release. Many congrats to Meghan for this 20-page opus! 4/n.
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Upon ERK1/2 inactivation, the mRNA stability protein TTP becomes dephosphorylated and unstable. This causes mRNA half life to be increased and causes multiple cytokines and chemokines to be released at high level.s 3/n.
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In this work, Meghan found that inflammasome agonist exposure rapidly caused inactivation of ERK1/2. This inactivation was due to mitochondrial disruption causing activation of the dual specificity phosphatase DUSP6. 2/n.
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We are excited to share a new paper from the lab - led by first author and @cwrumstp @cwrusom student Meghan O'Keefe. 1/n. Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP: Cell Reports
cell.com
O’Keefe et al. determined that inflammasome agonists, working through the mitochondria, rapidly inactivate ERK1/2. They further show that the ERK substrate, TTP, is also inactivated, leading to...
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RT @ImmunologyAAI: In response to the the firing of probationary workers across the federal government, AAI issued the following statement….
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I Used to Run the N.I.H. Here’s What Worries Me.
nytimes.com
The Trump administration hobbles research and endangers the public health.
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Is anybody's university telling them that No Cost Extensions are no longer allowed by the NIH? We are hearing this from our research office, but I can't find anything online. @drugmonkeyblog @mbeisen.
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Congrats to colleagues George Dubyak and Xinghong Dai on this groundbreaking work showing NINJ1 and 2's roles in membrane integrity. A great collaboration that started after a departmental seminar!.
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I'm very humbled and excited to announce a career change come summertime. Thanks to all at Case Western for a wonderful and productive 18+ years.
nationaljewish.org
Following a national search, National Jewish Health named Derek Abbott, MD, PhD, the Cecil and Ida Green Chair of the Department of Immunology and Genomic Medicine. Dr. Abbott is currently the Arline...
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