A broader take on the role of DNA damage in cancer, providing some context for our work on MBD4 and methylation damage: https://t.co/KDsoNXsm5p

Niche gift idea. For that special person in your life interested in DNA repair mechanisms that protect from ageing. Get them a copy of our preprint. Includes a detailed analysis of somatic mutation patterns in models of DNA repair deficiency - Mbd4, Tdg & Msh6.

I am looking for a postdoc to join my new team in Melbourne, Australia at WEHI to work on lung stem cells and disease, including lung cancers! International candidates+ those just finishing up PhDs welcomed Please apply below: https://t.co/VUVq7XwoMf

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine. https://t.co/07aJu9e8DM #biorxiv_molbio

Very good to see and be involved in such a deliberate and positive step forward for safer indoor air. Trailblazing from @VicGovAu. https://t.co/Kb8Z8ppJ22

⭐️ Job opportunity ⭐️ We're looking for an exceptional scientist to provide leadership and focus for RNA biology as a new Laboratory Head at WEHI. More info: https://t.co/15m2FOhfjb

Preliminary program for Cancer Bioinformatics Australia has been announced and it looks great @VicCanBioinf 25th June Melbourne >80% tickets sold. Be quick to register https://t.co/lx1AQlHn1s

OPINION | Medical research has been sold short- AAMRI President @ProfHartland on funding cut for Vic medical researchers: "We pride ourselves on making money go a long way, but no amount of thriftiness will buffer a $50m cut" Published today @theheraldsun

Are you an undergraduate science student keen for a taste of medical research? Applications for the 2024 Metcalf Scholarship program are now open. Work within our leading research groups tackling important questions in medical research. Find out more 👉 https://t.co/JcSdPSKwtu

Save the date! Have you heard the we are running a cancer bioinformatics symposium in June? Registration and abstract submission are opening soon! https://t.co/rg1z0Rtz8M

An important Victorian study released today confirms mosquitoes transmit Mycobacterium ulcerans, the bacteria that causes Buruli Ulcer. Another reason to protect against mosquito bites. Learn how to protect yourself & your loved ones: https://t.co/eCgN6iilII

Remember when we used to talk about heading towards 3%GDP? Now we are in a race to the bottom of the OECD. Australia being ‘left behind’ as federal research and development funding sinks to 30-year low | Australian economy | The Guardian

I am going to be hiring postdocs shortly for an exciting new project. If you are excited by DNA repair, functional assays, haematopoiesis, please write to me!

We have a Bioinformatics Research Assistant / Research Officer opening in my team @WEHI_research https://t.co/I4gcfzIhSC. If interested, feel free to say hi👋 at #abacbs2023 during a break or at my poster (EL-15) on long-read RNA-seq today (full story at https://t.co/MtvyswZkHD)

Further work is required to understand how cell context or disease status influence the mutagenic potential of NHC. The paper is open access and primary datasets are available.

What did we do? We quantified DNA damage by sequencing DNA from cell lines treated with NHC. Inactivating uridine-cytidine kinase 2 (Uck2) lowered the toxicity and mutagenicity of NHC. Limits? We only tested cell lines, so there is still lots to learn about NHC in normal tissues.

We found that in cell lines pyrimidine salvage stimulates the mutagenic activity of the antiviral NHC, the active component of molnupiravir. This metabolic quirk may explain why NHC induces high levels of DNA damage in cells grown in the lab, but not in safety tests in animals.

Our latest paper @NAROpen looks at how ribonucleoside analog drugs can impact the genome and how this varies based on metabolic wiring in cell lines. Uridine–cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine https://t.co/m98yGNSiOY

We are hiring! Looking for a postdoc interested in epigenetics and blood cancers. Check out our add. Please RT

🌏 Applications are open for our International PhD Scholar Initiative, helping outstanding students from outside Australia undertake a medical biology #PhD at WEHI. #StudyInAustralia Scholarship and application info 👇 https://t.co/c32y0HsJbV

I'm hiring! Are you looking for a postdoc position in computational biology? Are you interested in cancer and working with unique patient tissue omics datasets (spatial, single-cell, bulk)? Do you want to work at the amazing Peter Mac in Melbourne? ->