Hugo Barreto
@hugocbarreto
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Marie Skłodowska-Curie Postdoc Fellow @InstitutCochin Tenaillon Lab. PhD alumni @IGCiencia Interested in host-microbe interactions and evolution.
Joined April 2018
Excited to share the first paper coming out of my postdoc @InstitutCochin ! Ever wondered which #genomic regions are more prone to #replication errors in #Ecoli and why? A small 🧵 below (1/) Link to full paper: https://t.co/6AQ2xbVYiI
@NAR_Open
academic.oup.com
Abstract. Fidelity of DNA replication is crucial for the accurate transmission of genetic information across generations, yet errors still occur despite mu
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Hiring 2 Postdocs (CNRS Research Engineer) in Nice 🇫🇷. Intestinal aging & immunity in fish 🐟: 1) Zebrafish immunosenescence—ANR ImmunoGUT 2) Reef-fish intestinal aging—ANR GUTPOWER. Start Nov–Dec 2025 • ~€3,175/mo. Profile: aging/epithelium or immunology; zebrafish a plus👇
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February is full of interesting #seminars! Check our monthly newsletter and don't miss them 🗓️ We also take this opportunity to announce we are transitioning to less cloudy weather🦋 after the latest events. You can find us there under the same username #parispostdocs
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Happy to welcome Dr. François-Xavier Mauvais @InstitutCochin for a @ParisPostdocs seminar. It was an enlightening talk and a great discussion. Protocols are being exchanged and collaborations are emerging. This is what @ParisPostdocs is all about. @albiglero @hugocbarreto
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Don't miss out on and join François-Xavier Mauvais seminar on the 15th of January at noon in @InstitutCochin. François-Xavier works on the role of splenic #macrophages in the #immunity against #tumors at @NeckerInem. @albiglero @hugocbarreto @ParisPostdocs
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Our latest work highlighted by @CNRSbiologie ! ⚡ 🧬 🦠 You can read the full paper here:
academic.oup.com
Abstract. Fidelity of DNA replication is crucial for the accurate transmission of genetic information across generations, yet errors still occur despite mu
#ResultatScientifique🔎| Cartographie des points chauds de mutations du génome d’Escherichia coli 🤝 @CNRS @CNRS_Villejuif @Inserm @univ_paris_cite @InstitutCochin ✍️ Ivan Matic 📕 @NAR_Open | https://t.co/sYVTqIDsHZ
https://t.co/yOASt5oD5c
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@NAR_Open You can also find this work highlighted in @InstitutCochin website: https://t.co/DimRdvqHbp
institutcochin.fr
This study conducted by Ivan Matic’s team presents a comprehensive genome-wide map of DNA replication error hotspots in the Escherichia coli genome, shedding light on the mechanisms that undermine...
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Huge thanks to Flavia, Chantal, and Ivan for the awesome journey preparing this story! Looking forward for the next ones😃 You can find the full story here @NAR_Open : https://t.co/6AQ2xbVYiI (end/)
academic.oup.com
Abstract. Fidelity of DNA replication is crucial for the accurate transmission of genetic information across generations, yet errors still occur despite mu
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Overall, our findings provide a comprehensive map of replication error hotspots across the E. coli genome, associated with specific genomic features and proteins. However, each region as its own history, with the combination of features being region-specific (6/)
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Furthermore, genes with high transcription activity (such as rRNA and tRNA) are highly enriched in replication error hotspots. GO analysis also revealed a strong enrichment for core cellular processes, such as #transcription, #translation, and #metabolism (5/)
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These hotspots show enrichment for several features, such as binding sites of nucleoid-associated proteins, lower thermal stability, #mononucleotide repeats, and sequences prone to forming secondary structures (4/)
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We then performed MutL-ChIP-Seq to identify replication error hotspots in E. coli genome. These #hotspots are not randomly distributed and exhibit diverse patterns: single, overlapping, and asymmetric (3/)
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While DNA replication is highly accurate, errors can occur and lead to mutations. We took advantage of E. coli mismatch repair machinery coupled with fluorescence microscopy to quantify replication errors at the single cell level, in cells where mutations are left unrepaired (2/)
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Another great @ParisPostdocs #seminar at @InstitutCochin. Dr. Francisco J. Martinez from @institutpasteur presented his work on #antibody mediated mechanisms that correlate with #malaria protection. Thank you Francisco for the presentation and the discussion. #postdoc #research
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Don't miss out on Francisco J. Martínez's seminar the 12th of December at noon at @InstitutCochin. He will present his researcher done @institutpasteur on the "Antibody-mediated mechanisms that correlate with #malaria protection". All the info here: https://t.co/b96jx2Mso2
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What a pleasure to have @koh_cassandra today at @InstitutCochin as part of the @ParisPostdocs Seminars series! Thank you Cassandra for the interesting insights and novel approaches to study mosquito viromes - and she’s #hiring 📢❕@ERC_Research
@SFaureDupuy @hugocbarreto
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Paris Postdocs seminar series: on November 7 at noon @InstitutCochin, Cassandra Koh (Viruses and RNA Interference Unit, @institutpasteur Paris) will talk about #Mosquito-specific viruses and their impact on #arbovirus disease ecology https://t.co/Iez5MDt02Z
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What a month! October is full of exciting talks - check our monthly newsletter and don’t miss them ‼️🚨 see you at @CRCordeliers @institutpasteur @institut_curie @IJMonod @IBPS_Paris
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Are you looking for a pos-doc? We just opened two positions to study bacteria evolution in the gut in Gordo's Lab at the Gulbenkian Institute ;)! See https://t.co/5pKdPeDAO2
https://t.co/k0zkz0Y23A
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Don't let the end of summer vacations get you down! There's so much exciting science ahead! Check out our September 2024 newsletter 🦠🧫🧬
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