
Michael Hla
@hla_michael
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RT @alexisohanian: Thrilled to announce our 2025 @776foundation Fellows! I’m giving each fellow $100k to tackle one of the biggest threats….
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Thanks again to the @adaptyvbio team! Uploaded a csv of sequences and got super detailed assay results with no overhead. Would highly recommend.
Pro-1, a protein design model by @hla_michael, doesn’t just propose mutations — it explains why it made them. We tested 19 of its FGF-1 designs in our lab and 3 of them improved thermostability while maintaining binding. In this protein designer spotlight we explain how
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RT @andrewwhite01: I want to point out that over the last few weeks there has been other great work on building reasoning models in biology….
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Special thank you to @julian_englert @danielnzg85 and the @adaptyvbio team for sponsoring this validation. The entire process was seamless and would highly recommend their services!.
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First Lab Validation for Reasoning Model Proteins. With @adaptyvbio, we tested 19 FGF-1 sequences optimized by Pro-1 for thermal stability and binding affinity to human FGFR-1. Pro-1 produced 3 novel sequences that maintained binding affinity and expression compared to wild
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