Helen Murray, PhD
@hcmurray6
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Scientist and ice hockey player | studying CTE neuropathology @ Centre for Brain Research, UOA in Auckland NZ | #NZIceFernz
Auckland NZ
Joined September 2014
Tau lesions in chronic traumatic encephalopathy (CTE) are also sites of concentrated glial reactivity. In our recent paper we used multiplex immunohistochemistry to explore the microenvironment of these lesions.
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If you're at #ADPD2025 come see us at poster 564 (Chelsie) and 587 (me).
Tau lesions in chronic traumatic encephalopathy (CTE) are also sites of concentrated glial reactivity. In our recent paper we used multiplex immunohistochemistry to explore the microenvironment of these lesions.
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Huge thank you to our collaborators including @drmbuckland and @annmckeemd who supplied the CTE tissue for this study, and congratulations to my PhD student .Chelsie Ostermann who was the lead author on this paper.
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Our labelling shows that markers for astrocyte reactivity were most concentrated around the lesion vessels.
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We investigated markers of microglial and astrocyte reactivity, different tau species, ubiquitination, neurofilaments, neurons and blood vessels in lesion and non-lesion areas of frontal cortex from CTE cases.
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RT @FirstConcussion: New episode with @hcmurray6 is now live! Dr Murray offers valuable insights into Chronic Traumatic Encephalopathy (C….
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Thanks to the #AWCBR2024 organizing committee for a very successful conference. Can't wait to do it all again next year. 3/3.
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But the highlight was watching my PhD students, Chelsie and Danica, give such excellent presentations. Huge congrats to Chelsie for winning the Goddard Prize for the best student oral presentation!. 2/3
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It's been a brilliant week at #AWCBR. Surrounded by the best people in one of the most beautiful places in the world. Also very grateful to give one of the plenary talks, and have such a substantial time slot for our CTE neuropathology symposium. 1/3
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Huge thanks to @NeurologicalNZ who fund my fellowship and Danica's doctoral scholarship, .@HRCNewZealand for funding this research and our fantastic coauthors at @FMHS_UoA.
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Massive congratulations to my PhD student Danica Hamlin for bringing this all together - her first first-author paper!.
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We show that tangles can be classified into different maturity levels using antibody labelling signatures. This reproducible and efficient method of quantifying the maturity of individual tangles will be useful for future studies of tau pathology.
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Tangle populations characterized by advanced tau immunophenotypes were associated with higher Braak stage and more mature tangle morphology.
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We co-labelled four antibodies associated with early and advanced tangle maturity and used @FijiSc to segment individual tangle objects. Using spectral clustering we identified five distinct populations of tangles in Alzheimer's disease brains.
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We were intrigued by @DrChristinaMo and @DrNeuroChic excellent 2021 review on neurofibrillary tangle maturity and wondered if we could apply our multiplex IHC approach to identify an immunophenotype signature for tangle maturity.
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Our paper exploring the antibody labelling signature of neurofibrillary tangle maturity in Alzheimer's disease is out now in @alzdemjournals.
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One of my favourite interviews ever. Thank you @SallyHoerr for taking the time to showcase my research and NZ womens hockey @NZIceFernz. Give the @TheIceGarden a follow to keep up with all things womens hockey.
New Zealand's own Dr. Helen Murray continues to break new ground on the ice and in CTE research.
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RT @ChrisNowinski1: From the NIH Director's Blog: .New Findings in Football Players May Aid the Future Diagnosis and Study of Chronic Traum….
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RT @VDieriks: 🚀Just Released!'Aggregate-prone brain regions in Parkinson’s Disease are rich in unique N-terminus α-synuclein conformers wit….
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