Explore tweets tagged as #ezh2
@BeatrizGerFalc summarizing some of her latest work with the lab. #EZH2 controls cell plasticity in #ProstateCancer through coordination with activation of #translation and the RNA degrading protein #tristetraprolin @CPDR_Labs
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Dr. Sam Yamshon from @WeillCornell promisingly presented at #davaheme preclinical & clinical rationale for combining CAR-T therapy with EZH2 inhibitor tazemetostat in DLBCL. #bloodcancer #Lymphoma
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Online Now: Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function
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Online Now: Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function
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#Follicular Lymphoma (FL) Tx Pathway.🔹1st-line: Chemoimmunotherapy ± CD20 maintenance.🔁If R/R: Lenalidomide + CD20 Ab.🔁 If R/R again:.▶️ BsAbs (mosunetuzumab, epcoritamab).▶️ CAR T (axi-cel, tisa-cel, liso-cel).▶️Zanubrutinib + obinutuzumab.▶️ Tazemetostat if EZH2^mut or frail
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🚨 New Era with biomarker-driven trials in Prostate Cancer Therapy lies ahead!. 🧬Molecular stratification is revolutionizing metastatic prostate cancer treatment. From ARPIs to PARP inhibitors (BRCA2/PALB2), ICIs (MMRd), and PSMA-targeted therapies, novel targets like EZH2,
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EZH2 inhibition in #ProstateCancer: MEVPRO-1 phase III trial update. @neerajaiims @huntsmancancer joins @zklaassen_md @GACancerCenter in this discussion on UroToday >
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#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10!
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New #JITC article: EZH2 inhibition and 5-azacytidine enhance antitumor immunity in PTEN-deficient glioblastoma by activation viral mimicry response
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My continued biomedical education.#MASLD #MASH. Pathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease. Lots of enjoyable content😋. SNP (#LipidDroplet centric) PNPLA3 TM6SF2 MBOAT7 GCKR HSD17B13. LncRNA MEG3-EZH2-SIRT6. Lean vs Obese MASH
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Targeting lineage plasticity in #ProstateCancer with EZH2 inhibitor mevrometostat. @MikeSchweizerMD @fredhutch sits down with Oliver Sartor, MD @MayoClinic diving into #mevrometostat—an #EZH2 inhibitor tackling lineage plasticity in #mCRPC. Adding it to enzalutamide slashed
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Differentiating thymoma and thymic carcinoma is important and has many implications. But it is often challenging. Certain markers such as CALML4, EZH2, POU2F3 (in addition to the traditional markers c-kit, CD5, TdT) could be helpful in aiding the diagnosis. #ITMIG2024
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🔬Understanding DLBCL classification:.🧬 Genetic signatures & associated genes define:.🔴 Activated B-cell (e.g., MYD88, CD79B).⚪️ Germinal center B-cell (e.g., EZH2, BCL2).⚪️ Unclassified subtypes. Key for targeted therapies& prognosis! #Hematology #Oncology.✒️By Provan et al
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Great wrap-up at #AACR24! Big thanks to all who joined us to explore immune interception strategies for Lynch-related colorectal cancer via EZH2 inhibition. #CancerPrevention #EZH2 #LynchSyndrome #Vilarlab
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#ASCO25 TiP - MEVPRO-2: Ph 2 RCT of mevrometostat (MEV) + ENZA vs placebo + ENZA in ARPI-naive mCRPC.🔹MEV: Selective inhibitor of EZH2 (histone methyltransferase involved in epigenetic regression of target genes).🔹MEV + ENZA: ⬆️activity + safety in ARPI pre-Tx mCRPC (Ph 1/2
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CONGRESS | #EHA2025 | PRESENTATION.Yuqin Song, Peking University Cancer Hospital, shares results from a phase I trial of SHR2554, an oral, small molecule EZH2 inhibitor, in patients with R/R PTCL (N = 67). The primary endpoint was met, with an ORR of 64.2%. A phase III trial
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Single-cell profiling of EZH2-mediated immune signaling perturbations in NSCLC #biorxiv_bioinfo.
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🎯 New therapeutic strategies for metastatic prostate cancer include PARP inhibitors (BRCA2/PALB2), ICIs (MMRd), 177Lu-PSMA-617, and novel targets like EZH2, PI3K/AKT, and AR cofactors. Precision oncology is reshaping care. @EUplatinum .🔗 #CánCare
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