A preconditioned stochastic gradient descent approach can potentially enable a simple and unified approach to ab initio reconstruction and high-resolution refinement with faster convergence speed and higher flexibility #CryoEM #HomogeneousRefinement 

Bogdan Toader et al.: Efficient high-resolution refinement in cryo-EM with stochastic gradient descent #CryoEM #HomogeneousRefinement #StochasticGradientDescent @unewhaven. #IUCr