Hannah Donnelly
@hannahdonnelly_
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@BBSRC Discovery Fellow | bioengineering primary & secondary lymphoid organs in vitro | @theglasgowcemi 🩸🦴
Glasgow, Scotland
Joined November 2013
Beyond delighted to share our latest work from @theglasgowcemi @DalbyMatthew @ManuelMime, published yesterday in @NatureComms. Here we bioengineer a model of the bone marrow niche microenvironment that can maintain long-term HSCs 🦴🩸 https://t.co/HMO4oAodKx
nature.com
Nature Communications - The ability to maintain blood stem cells (HSCs) in vitro would allow us to provide better therapies for blood diseases. Here, the authors report that polymer-organised...
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Scientists @UofGlasgow have successfully used the first bioengineered bone marrow model to carry out vital cancer research, offering new insights into potential therapies for the disease. More ➡️ https://t.co/bbVbS2SS09 Read the full paper ➡️ https://t.co/Ljz1Fc9sbM
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Glasgow scientists create first lab-grown bone marrow to study cancer. https://t.co/I23yhXIVzs
news.stv.tv
Researchers say the breakthrough is an important step forward in being able to carry out medical research without the use of animals.
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Delighted to share that our work on #cadherin and #integrin crosstalk has been published in @NatureComms after so much effort. Thanks to all the people that made it possible @marcocantini24, @ManuelMime, @DalbyMatthew, @MarianaAG0, @finbeag and more!
nature.com
Nature Communications - The crosstalk between cell-cell and cell-matrix adhesions regulates stem cell fate. Here, the authors reveal a critical role for matrix viscosity in controlling this...
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The CeMi are incredibly excited to bring the MAINSTREAM Hub to Scotland, led by @DalbyMatthew (cont'd in comments)....
A team led by @UofGlasgow will use pioneering tech to manufacture human stem cells outside the body, in the hope they could help transplant therapies & develop new approaches to blood cancer treatment. @DalbyMatthew @UniStrathclyde @UniofNottingham ➡️
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Delighted that @theglasgowcemi will lead the MAINSTREAM UK hub for stem cell manufacturing with @UoNCfAM and @StrathBiomedEng.
The CeMi are incredibly excited to bring the MAINSTREAM Hub to Scotland, led by @DalbyMatthew (cont'd in comments)....
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Reminder: 3-Year PhD Studentship Deadline Approaching! Application Deadline: September 4th Fully Funded with fees & stipends covered! Apply @ https://t.co/HcZNQcYYYy
#PhDOpportunity #LeukaemiaResearch #Bioengineering #StemCells #MedicalResearch #FullyFundedPhD #lifETIMECDT
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Massive thanks to everyone who supported the application and the journey 🙏🏻
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Beyond delighted to have been awarded a BBSRC Discovery Fellowship! Where I’ve recently returned to @theglasgowcemi to bioengineer primary and secondary lymphoid microenvironments 🦴🩸
Meet the 15 new BBSRC Discovery Fellows who are receiving a collective £6m of investment for early-career independent research. The fellowship scheme, now in its 10th year, supports promising researchers who aspire to secure the future of biosciences. https://t.co/Tu4Djsy2yZ
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Exciting PhD opportunity with @CDTLifETIME and @hannahdonnelly_ at the @UofGlasgow To apply, please visit https://t.co/EtC3Chk52E
#PhDOpportunity
#LeukaemiaResearch
#Bioengineering
#StemCellResearch
#DrugDevelopment
#MedicalResearch
#FullyFundedPhD
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🚨PhD position available with @DalbyMatthew and myself, bioengineering the bone marrow microenvironment and more! Please contact me to enquire and share with any keen bioengineers 🦴🩸
📢📢We have a new 3 year studentship available at @UofGlasgow! 👩🔬👨🔬 Deadline 04/09/2024 Please apply here: https://t.co/LW6vR4h7QX Project info here: https://t.co/ufrTE0EKuh
#PhDposition #phdproject #PhDOpportunity #PhDProgram
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1/2 Scientists @UofGlasgow have created the first bioengineered bone marrow model which can support the type of human stem cells that are crucial for bone marrow transplants and in vitro study work 🧬 More ➡️ https://t.co/rixXPGAy2B
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Happy to see this work by @hannahdonnelly_, @theglasgowcemi’s new @BBSRC Fellow published in @NatureComms. It shows bioengineered microenvironments containing mesenchymal stem cells can look after long-term haematopoietic stem cells. Critical for improved blood cancer therapies.
Beyond delighted to share our latest work from @theglasgowcemi @DalbyMatthew @ManuelMime, published yesterday in @NatureComms. Here we bioengineer a model of the bone marrow niche microenvironment that can maintain long-term HSCs 🦴🩸 https://t.co/HMO4oAodKx
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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells https://t.co/M1VwGU7Au2
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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells https://t.co/gPOheZ0fWS
nature.com
Nature Communications - The ability to maintain blood stem cells (HSCs) in vitro would allow us to provide better therapies for blood diseases. Here, the authors report that polymer-organised...
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Dr. Hannah Donnelly at @UofGlasgow and team provide proof-of-concept that bioengineered niches that recreate physiological ECM organization can support the survival of #CRISPR edited hematopoietic stem cells. https://t.co/62IdWMJ9b4
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Massive thanks to all involved, truly cross-disciplinary and always a team effort - @RossLabGroup @Yinbo_Xiao @riohermantara @AqeelTaqi @Seb_sci @michieCLLlab @jodiefhay @Nikhil_Jain12 @LabWheadon @UofGSMB @UofGMVLS @UofGSciEng @UofGlasgow @BBSRC @EPSRC @The_MRC @CarnegieUni
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We show that our bioengineered niches can maintain notoriously tricky to culture long-term HSCs. We even do a little proof-of-concept looking at using bioengineered niches to support HSCs post-CRISPR editing 🩸🩸🩸
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Here, using stromal stem cells, hydrogels & material-driven ECM organisation, we investigate mechanics & hypoxia. Using low-stiffness hydrogels to drive niche-like phenotypes in stromal stem cells, we begin to unpick the role of nestin expression in these key HSC regulatory cells
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