Guomics
@guomics
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Proteomics Lab at @Westlake_Uni
Hangzhou, China
Joined October 2020
It is a great pleasure to write with Judith @ionicwoman.and Matthias @labs_mann about the recent ten-year summary of MS-based proteomics and think about the future.😊 @Nature .
nature.com
Nature - This Review summarizes advances in mass-spectrometry-based proteomics and explores the potential applications of these technologies in the clinic.
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🔥 REGISTER NOW: Westlake Symposium on AI Proteomics & Virtual Cell!.🔗🗓️ Oct 8-9, 2025.📍 Westlake University, Hangzhou, China.📧zhuhuinan@westlake.edu.cn.Join global pioneers at the intersection of AI+Life Science! #AIProteomics #VirtualCell #AIinScience
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This weekend, we successfully hosted the Westlake Symposium for AI Virtual Cell at Westlake University. Brilliant minds from biology, multi-omics and AI came together to explore how how to build a virtual cell. Thank you all for joining us!.#AIVC #AI #WestlakeUniversity
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Our recent collaborative study with Connie R. Jimenez’s team at @VUamsterdam is now published in Cancer Cell:.The Pan-Cancer Proteome Atlas (TPCPA) maps 9,670 proteins across 22 cancer types, offering new insights into tumor biology and biomarkers.
cell.com
Knol et al. report a large pan-cancer proteome landscape based on high-throughput, single-shot mass spectrometry across 22 cancer types including both liquid (n = 4) and solid cancers (n = 18),...
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Superb job! 🎉.
Nano-scale, mega-impact: nanoPhos delivers 100× phosphoproteomics sensitivity, 70k sites from 1µg, 8k from 10ng! Powered by SPEC, it enables phosphoDVP: deep spatial phosphoproteomics from 1000 neurons, hitting 17k sites, a game changer for spatial omics.
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New in EMBO Molecular Medicine: Our multi-center study developed a 24-protein classifier that distinguishes follicular thyroid adenoma from carcinoma with high accuracy.
embopress.org
imageimageA proteomics-driven 24-protein classifier improves the differentiation of thyroid adenoma and carcinoma, retrospectively and prospectively validated across multi-center cohorts, with up to...
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Join us at Westlake University (June 7–8, 2025) for the Westlake Symposium for AI Virtual Cell — exploring how AI and omics data are reshaping our understanding of cellular systems.
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Our latest multicenter proteomics study (n=1085) reveals key proteins—MVP, IGF2R, HDAC1, H1-5—driving follicular thyroid cancer (FTC) progression. These findings offer promising targets for future diagnostics & therapies.
journals.lww.com
this study aims to identify the mechanisms underlying FTC is essential. Methods: Using parallel reaction monitoring-mass spectrometry (PRM-MS) assays, we identified and quantified 94 differentially...
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Bead-based NP enrichment enables deep profiling of plasma proteins, but platelet/RBC carryover can inflate IDs and skew quant—as shown in our bioRxiv study and .@labs_mann 's five-workflow comparison. High-speed spin+strict volume control+beads=max depth, minimal contamination.
To bead or not to bead? We evaluate five plasma proteomics workflows, finding bead-based methods enhance detection but show high susceptibility to cellular contamination bias. Strategies to optimize biomarker discovery in plasma proteomics.
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Congratulations! @NordmannThierry 👍.
Since April, @NordmannThierry has been leading the Research Group "Molecular and Spatial Biology of the Skin" @MPI_Biochem He has now been awarded the prestigious Oscar Gans Prize by the German Dermatological Society. Congratulations and welcome!. #OscarGansPrize @labs_mann
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DIA-MS has become an important tool in quantitative proteomics. 🔬Guomics at WestlakeUni introduces DIA-BERT, a transformer model pre-trained on existing DIA datasets, with 51%↑ protein identifications.📈#Proteomics #DIABERT #AI .Details at
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How to grow AI Virtual Cells (#AIVC #AIinBio) by Guomics@WestlakeU:.📚Prior knowledge +🧬Static architecture +Dynamic states.🤖 Closed-loop AI + robotic experiments → iterative model refinement. Starting with S. cerevisiae as scalable prototype. 🔗
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RT @WestlakeOmics: New in @NatureComms ! .Researchers from @UUBeta optimized Orbitrap Astral for plasma N-glycoproteomics, achieving 3,000+….
nature.com
Nature Communications - While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for...
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A powerful step toward understanding health disparities 😊.
New study in Nature Medicine explores how social disadvantage accelerates biological aging and increases the risk of age-related diseases (ARDs). The findings highlight key inflammatory proteins involved in this process.
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congrats!.
Thrilled to share our latest work published in @CellCellPress: Turnover Atlas of Proteome and Phosphoproteome Across Mouse Tissues and Brain Regions! @Yanshen73854711 @JunminPengLab @euforna @YaleMed @YalePharm @CancerYale @HUPO #Proteomics #TeamMassSpec.
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go go go!!!.
🚨 Don't Delay, Submit Your Application Today!🚨.The 11th Annual ECR Manuscript Competition at HUPO 2025 in Toronto (sponsored by Taylor & Francis) is your opportunity to gain recognition, showcase your research, and make an impact. 🔗 Submit now:
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Promising insights for cancer immunotherapy.
New in Nature Biomedical Engineering!.Researchers from @Caltech developed Morpheus, a deep-learning framework that uses spatial proteomics & counterfactual optimization to enhance T-cell infiltration in tumors.
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Could this be a step toward scar-free healing in humans? 👀.
Stanford researchers show that inhibiting YAP with a single dose of verteporfin promotes scarless wound healing in Duroc pigs 🐷—a model close to human skin. Findings were validated in a human xenograft model. @Stanford .
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New preprint alert! ✨.Our team developed ProteinTalks, a dynamical foundation model for understanding protein network dynamics from large-scale perturbation proteomics🧪.A step forward for drug discovery, precision medicine, and virtual cell modeling!.
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New preprint alert! ✨.Our team developed ProteinTalks, a dynamical foundation model for understanding protein network dynamics from large-scale perturbation proteomics 🧪. A step forward for drug discovery, precision medicine, and virtual cell modeling!.
biorxiv.org
Building a virtual cell requires comprehensive understanding of protein network dynamics of a cell which necessitates large-scale perturbation proteome data and intelligent computational models...
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