David Thorn
@gammaDave1
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A lover and a friend to all proteins... the good, the bad and the amyloid
Joined June 2019
In our recent @JMolBiol paper, @AidanGrosas and I describe a mechanism where the aging of a protein in the human eye lens leads to cataract and blindness. We crystallized the protein with the help of @Jackson_Lab which proved to be the icing on John's cake
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Coming full circle @iserworld #iserwow2023 .The room our eyes first met at #ISER2018.The ring💍 @EyeDaisyShu.Presenting the crystal structure of the eye lens protein derived from the ring at #ISER2023
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RT @EyeDaisyShu: Don't forget to register for our upcoming @ASIPath Trainee Hangout with Alex, @michelejalves and featuring @RealRobertoMot….
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Sailing on the Charles River. If only research were this breezy!
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RT @EyeDaisyShu: Entering the @BioRender #DesignAMask contest! 😍 Please vote by liking and retweeting! My design reflects my research which….
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Do your proteins practice molecular distancing?. In this timely piece, @AidanGrosas shows why the molecular chaperone αB-crystallin is best to steer clear of crowded places.
Very excited to see this one out!. With Agata on large-scale #deuteration, Jitendra on the #SANS beamline @JitendraMata, David on the TEM @gammaDave1, and John bringing the expertise. An awesome collaborative effort. Thanks @deuteration for highlighting!. A short thread. .
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Did you know that Midichloria mitochondrii is an endosymbiont found in tick mitochondria? Its name comes from George Lucas’ midi-chlorians, the organisms present in all living cells that give rise to The Force #MayThe4th
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RT @jjyerbury: When you heat up🔥 an egg all the proteins aggregate & precipitate out of solution & turn white🍳. Living cells can protect t….
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RT @jjyerbury: For Christmas this year a paper has been published by a US team that for the first time 'cures' mice with SOD1 #MND! It is n….
nature.com
Nature Medicine - Injection of AAV–shRNA below the pial surface of the spinal cord prevents onset or ameliorates progression in a mouse model of ALS, and achieves widespread delivery to the...
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Please welcome the newest doctors on the block, my very own Dr Bahraminejad @ANUChemistry and Dr Shu @Sydney_Uni who both graduated on Thursday. All the best in your pursuits beyond the PhD! #womenInSTEM #PhDone
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Here's me making the most of the 6th International Conference on the Lens in Hawaii thanks to budding Harvard researcher @EyeDaisyShu. See here for her tips in full!.
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RT @ASIPath: Congratulations to @ASIPath Committee for Career Development and Diversity Member, @eyedaisyshu on getting awarded her PhD fro….
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RT @AidanGrosas: Having worked with alphaA throughout my PhD, finally seeing its structural model is awesome! Impressive work! Interesting….
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Our application note describing a method to monitor the early stages of amyloid fibril formation has earned a Digital Marketing Award. Developed at @LIMSLTU and @ANUChemistry by @yuning_hong, @KumarJManjeet and others. Click here for download: #amyloids.
bmglabtech.com
Detect even prefibrillar protein aggregates with high sensitivity combining fluorescence polarization, the fluorophore TPE-TPP and the CLARIOstar reader.
@BMGLABTECH has received a Digital Marketing Award for its application note describing a novel aggregation-specific fluorescent probe for monitoring prefibrillar protein aggregation. Read more:
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RT @AidanGrosas: Fantastic work by Carl, Jared, and John which describes why IDPs and regions of intrinsic disorder can favour protein-prot….
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It's official. cataract is in part an amyloid disease of the lens: The new findings highlight the seminal work of Meehan and co (2004; 2007) showing crystallin fibril formation in vitro. What about under crowded solution conditions as found in the lens?.
pnas.org
UV light and other factors damage crystallin proteins in the eye lens, resulting in cataracts that scatter light and affect vision. Little informat...
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I got my eye on the cover image of a paper that sums up two of my main research interests: casein and crystallin protein aggregation. Some bloodshot remains👀Needless to say I won't be modelling for L'Oreal. Credit to Mrs Bahraminejad for pouring the milk!.
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Professor Sir Dobson was modest about his achievements. When I thanked him for his help and contribution to the field, he replied "But the secret is that I have a fabulous group. I just keep up with them when I can." Thank you, Chris, for giving us something greater to aspire to.
Professor Sir Christopher Dobson, Master of St John's College, has died age 69. He is survived by his wife, Dr Mary Dobson, their sons, Richard and William, and his beloved dog, Jimbo. Full story and tribute to this extraordinary man: We are bereft.
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