futaki lab
@futaki_lab
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Biofuncional Design Chemistry/Intracellular Delivery/Peptides/Proteins/RNA at ICR @icr_ku, Kyoto University @univkyoto @KyotoU_News
Uji, Kyoto, JAPAN
Joined April 2022
We share another new research. A membrane lytic peptide-modified polysaccharide was developed in this paper. It forms a stable coacervate and efficiently delivers IgG into cytosol. This work has been selected as a cover in Bioconjug. Chem. #L17E #IgG
pubs.acs.org
Conjugates of the biocompatible polysaccharide pullulan with a cell membrane permeabilizing peptide L17E (PL-L17Es) were prepared with the aim of producing complex coacervates with pronounced...
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Our new work has been published in @MolTherapy. This paper demonstrates a novel mechanism of cytosolic delivery mediated by the L17E peptide and highlights the important role of the calcium-activated potassium channel KCa3.1 in supporting this delivery process.
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By modulating RNA-binding affinity, novel m6A erasers (modFTO & modALKBH5) were created that minimize off-target effects with programmable RNA-binding proteins and enable ligand-responsive control. This work has been selected as a cover in Chem. Commun.
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We're thrilled to share our new research about an innovative approach for precise and time-controllable m6A RNA demethylation. #m6A #Epitranscriptomics #RNA #ChemCommun
pubs.rsc.org
Recent advancements in tools using programmable RNA binding proteins and m6A-erasers enable sequence-selective and timing-controllable m6A demethylation. However, off-target effects are still a...
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https://t.co/AldjNvhRFL Our new review article highlights the design of intracellular delivery peptides and new delivery methods, such as coacervate, for intracellular protein delivery. #protein #delivery #peptide
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We are delighted to share our latest paper titled "ATP2B4 is an essential gene for epidermal growth factor-induced macropinocytosis in A431 cells." This research sheds light on #ATP2B4 as a pivotal gene related to #macropinocytosis induction.
onlinelibrary.wiley.com
Our study shows the critical involvement of calcium ions in macropinocytosis, especially in the process of ruffle closure. We identify ATP2B4 as an essential key regulator in epidermal growth...
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日本薬学会第144年会（@パシフィコ横浜）でシンポジウムを開催します [S58]「RNA疾患のメカニズムと創薬に向けたRNA操作」 3月31日(日) 09:45 〜 11:45 会議センター 502 (5F) https://t.co/d6VmagrENF 薬学会にご参加のみなさま、ぜひお越しください！
confit.atlas.jp
The 144th Annual Meeting of the Pharmaceutical Society of Japan (Yokohama),Elucidation of the mechanisms of RNA diseases and manipulation of RNA
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We are happy to share with you that our paper entitled "E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery" is now published online @JCRnEDITORS
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Our paper entitled "Liquid Droplet-Mediated Formulation of Lipid Nanoparticles Encapsulating Immunoglobulin G for Cytosolic Delivery" has been published online in @Mol_Pharm. https://t.co/c048bW2fR5
pubs.acs.org
Antibodies are promising biopharmaceuticals that offer new therapeutic options for diseases. Since antibodies are membrane impermeable, approaches that allow immunoglobulin Gs (IgGs) to access...
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AIにより機能性RNAを生成できる新技術「RfamGen」を@naturemethodsに本日発表しました！ RNA配列と2次構造を学習することで、目的の機能をもつRNAを効率よく生成できるAI, RfamGenを開発しました。大学院生の角君と浜田先生(@m_hama)との共同研究の成果です。 #AI #RNA https://t.co/t3Ei7v8781
nature.com
Nature Methods - RNA family sequence generator (RfamGen) is a deep generative model for designing novel, functional RNA sequences. RfamGen is applicable to diverse RNA families and can yield...
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本日尊敬する先生とお話する機会があり、心に留めたいことをメモします。 1. 基礎を徹底的に勉強する。 2. 一見当たり前と思われることも実際に手を動かし検証して、さらに技術と知識を高める。 3. 自慢話ではない魅力的な授業を準備して、学生と対話する。 4. 厳しい局面では覚悟をきめて対峙する。
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Futaki group has published a new article @ACS_AMI ! "Inkjet-Based Intracellular Delivery System that Effectively Utilizes Cell-Penetrating Peptides for Cytosolic Introduction of Biomacromolecules through the Cell Membrane" https://t.co/6MB6Z6M7n6
pubs.acs.org
In the drug delivery system, the cytosolic delivery of biofunctional molecules such as enzymes and genes must achieve sophisticated activities in cells, and microinjection and electroporation systems...
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Our new paper and collaborative work with @MotonariU, entitled "Xanthine derivatives inhibit FTO in an l-ascorbic acid-dependent manner", has been published in Chemical Communications.
pubs.rsc.org
Xanthine derivatives were identified as inhibitors of the N6-methyladenosine (m6A) demethylase activity of fat-mass-and-obesity-associated protein (FTO) by activity-based high-throughput screening...
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