
Pharmaceutical Science at FIP
@FIP_BPS
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FIP’s Board of Pharmaceutical Sciences sharing the latest news and views with scientists around the world.
The Hague, The Netherlands
Joined May 2019
In this perspective from Maria Laura Bolognesi and team, the UN Sustainable development goals are placed in the context of medicinal chemistry and outlines how we can “turn words into actions”.
pubs.acs.org
In 2015, the United Nations officially launched the Sustainable Development Goals (SDGs) as “the blueprint to achieve a better and more sustainable future for all. They address the global challenges...
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"Pharmacy practice research is the key to advancing global health," says Victoria Cardenas, Chair of the @FIP_PPRSIG. Read the full interview in the BPS newsletter – available in the FIP Library:
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A blood-first assay screening trial found entrectinib equally effective in advanced/metastatic non-small cell lung cancer patients diagnosed by liquid biopsy or tissue testing, achieving an 81.5% response rate. More in @NatureMedicine:
nature.com
Nature Medicine - Results from this single-arm cohort of the BFAST trial showed that the clinical efficacy of entrectinib in patients with ROS1-positive NSCLC, selected using liquid biopsies, is...
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RT @FIP_org: FIP’s Pediatric Formulations Focus Group study on paediatric compounding was featured in @HPE_magazine last week: https://t.co….
hospitalpharmacyeurope.com
Hala Fadda discusses FIP's new global study on global paediatric oral extemporaneous compounding practices.
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Personalised brain circuit scores reveal six biotypes in depression and anxiety according to a study by @StanfordMed, USA. These biotypes predict symptoms, behaviour & treatment response, paving the way for precision psychiatry. More in @NatureMedicine:
nature.com
Nature Medicine - A randomized controlled trial showed that following a personalized dietary program led to significant improvements in cardiometabolic and gut health as well as reductions in body...
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A personalised dietary programme can significantly improve aspects of cardiometabolic health compared to standard dietary advice, according to a randomised clinical trial conducted by the @KingsCollegeLon, UK. More in @NatureMedicine:
nature.com
Nature Medicine - A randomized controlled trial showed that following a personalized dietary program led to significant improvements in cardiometabolic and gut health as well as reductions in body...
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An organic-solvent-free method for peptide encapsulation in poly(lactic-co-glycolic acid) microspheres has been found by researchers from @UMich, USA, to offer sustained in vitro peptide release for over 56 days. Read more in @NatureComms:
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NMR and X-ray scattering methods were used by researchers from @Chiba_Univ_PR, Japan to examine how mixing sequence impacts structure & efficacy of small interfering RNA (siRNA)-loaded lipid nanoparticles . More in @JControlRel:
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Monoclonal antibodies against Acinetobacter baumannii, a multi-resistant bacteria associated with hospital-acquired infections, have been developed using genetically engineered mice by researchers at @Cambridge_Uni, UK. More in @NatureComms:
nature.com
Nature Communications - In this work, the authors describe immunisation of human antibody immune repertoire transgenic mice as a surrogate to define protective human antibody reactivity to...
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MED6-189, a compound inspired by marine sponge extracts, has demonstrated effectiveness against drug-sensitive & drug-resistant Plasmodium falciparum strains in vitro & in humanised mouse models, report @UCRiverside & @YaleMed, USA, in @ScienceMagazine
science.org
We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene natural products that is effective against drug-sensitive and drug-resistant Plasmodium falciparum strains,...
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A kidney organoid-based proximal tubule-on-chip (OPTECs-on-Chip) that closely mimics in vivo renal physiology has been developed by a team @KyotoU_News, Japan. More in @iScience_CP:
cell.com
Biomolecular Engineering; Molecular biology experimental approach
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New strains of Acinetobacter baumannii, a top priority pathogen identified by @WHO due to its role in multi-drug-resistant infections, have been engineered by @LivUni, UK, facilitating the development of medicines targeting this bacteria. More here:
journals.asm.org
Acinetobacter baumannii is a leading nosocomial pathogen that causes urinary tract infections, pneumonia, and skin/soft tissue infections (1). A. baumannii persists in hostile environments by readily...
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A new method to target GTPase enzymes linked to cancer & neurodegenerative diseases has been discovered @UCSF, USA. Researchers tested K-Ras-targeting drugs on other mutated GTPases, revealing new drug-binding sites. Findings in @CellPressNewsl:
cell.com
Morstein et al. demonstrate the feasibility of inhibiting GTPases beyond K-Ras, including various Ras-, Rho-, and Rab-family GTPases that were previously considered undruggable.
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The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by @ucl, UK. The study shows that different sequence variants in the gene form distinct DNA structures, impacting insulin regulation. More in @NatureComms:
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