Fasan Lab
@FasanLab
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At @UTDallasChemBio, we design & develop novel chemo-biosynthetic and chemo-enzymatic strategies for the discovery of biologically active molecules
Richardson, TX
Joined June 2017
Delighted to share our paper just appeared in Chemical Science on the discovery of macrocyclic peptides targeted against an RNA motif from SARS-CoV-2! Congrats to Jake, Andrew, and Abhijith @UT_Dallas. and great collab with Wedeking group @URochester_SMD.
pubs.rsc.org
RNA provides the genetic blueprint for many pathogenic viruses, including SARS-CoV-2. The propensity of RNA to fold into specific tertiary structures enables the biomolecular recognition of cavities...
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Photobiocatalytic Enantioselective Benzylic C(sp3)–H Acylation Enabled by Thiamine-Dependent Enzymes via Intermolecular Hydrogen Atom Transfer | Journal of the American Chemical Society
pubs.acs.org
Hydrogen atom transfer (HAT) constitutes a powerful mechanism exploited in biology and chemistry to functionalize ubiquitous C(sp3)–H bonds in organic molecules. Despite its synthetic potential,...
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On the International Day of Women and Girls in Science, a big shoutout to all the women in the @FasanLab @UTDallasChemBio for their outstanding contributions to our science! Go Aanu, Anwita, Elanor, Francesca, Hiram, Mary, Marriah, Michelle, Pamela, Ru, Shreya, and Yashika!🦾🎉
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Congrats to Jadab @majhijadab , Saty, and Anwita @Anwita_Ch for their recent paper in @ACSCatalysis on a new biocatalytic strategy for the asymmetric synthesis of oxazolidinones via intramolecular C-H amination with engineered myoglobins! Great job! 🎉👏.
pubs.acs.org
Oxazolidinones are important heterocycles widely utilized in medicinal chemistry for the synthesis of antifungals, antibacterials, and other bioactive compounds and in organic chemistry as chiral...
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Happy to share our recent paper on the regiodivergent C(sp3)–H functionalization of indolines via enzymatic carbene transfer in @ChemCatalysis Big kudos to lead authors Bo Couture and Ru Cui for the excellent work!🎉
www.cell.com
This work reports the development of an efficient biocatalytic strategy for the stereoselective and regiodivergent C(sp3)–H functionalization of N-substituted indolines, a privileged scaffold in...
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We are hiring! Our Department of Chemistry and Biochemistry at @UT_Dallas has two open-rank faculty positions in the areas of Biochemistry and Inorganic Chemistry, broadly defined. Come join a dynamic and vibrant department! .
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Excited to see our recent paper on chemoenzymatic DOS using engineered P450 enzymes highlighted in Chemical & Engineering News! Many thanks to Brianna Barbu for the great cover article and to Robert Huigens for the enthusiastic comments on our work!.
cen.acs.org
Researchers transform a single precursor molecule into 51 new and diverse structures
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Delighted to share our latest work on a Chemoenzymatic Diversity-Oriented Synthesis strategy for generating complex, natural-product-like compounds with enzymes. Big 👏to the lead authors Andrew Bortz and John Bennett for this beautiful work!🎉
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Great representation of the Fasan lab at #ACSFall2024 Postdoc Jadab Majhi @majhijadab & grad students Anwita Chattopadhyay @Anwita_Chand and Ron Adukure will present new biocatalytic strategies for the stereoselective synthesis of lactones, aminals, and halogenated cyclopropanes
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Congrats to our Anwita Chattopadhyay @Anwita_Ch for receiving a travel award from the ACS Division of Organic Chemistry to present at the #ACSFall2024! Thanks to the ACS DOC for their support and kudos to Anwita and fellow awardees!.
Congratulations to the Division of Organic Chemistry Fall 2024 ACS Travel Awardees (pictured with the Chair of the Awards Committee, Prof. Michael Pirrung).
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Congrats to our postdoc @majhijadab (left in the pic) for receiving UT Dallas Provost’s Office Postdoctoral Appreciation Award! Jadab will present his research at the 2024 ACS Fall meeting and at the Postdoctoral Research Symposium at UT San Antonio (Sept. 16). Way to go, Jadab!
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Check out our latest work on the stereoselective synthesis of pyridyl-cyclopropanes via enzymatic activation of pyridotriazoles just published in @J_A_C_S ! Congrats to @Satyajit_chem Yining Wang and rest of team @UTDallasChemBio @FollowStevens!
pubs.acs.org
Hemoproteins have recently emerged as powerful biocatalysts for new-to-nature carbene transfer reactions. Despite this progress, these strategies have remained largely limited to diazo-based carbene...
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Great experience at the 2024 Biocatalysis GRC in a week packed with excellent talks and great interactions. Thanks to Sabine Flitsch and Carlos Martinez for putting together a fantastic conference and great job by Bo Couture in presenting his work at the GRS and poster session
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Our latest work on stereoselective synthesis of difluorocyclopropanes is off the press in @Angewandte Congrats to lead authors @JuanDavidV24 @majhijadab and thanks to the ACIE editors for selecting our paper as VIP!.
#Biocatalysis Strategy for the Highly Stereoselective Synthesis of Fluorinated #Cyclopropanes (Rudi Fasan and co-workers) @FasanLab @JuanDavidV24 @majhijadab #proteinengineering #AngewandteVIP
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RT @ASterlingChem: ***We are hiring!***. My group is looking for a postdoc with comp chem experience to join us at @UTDallasChemBio from Au….
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Very excited about the upcoming joining of Alistair Sterling @ASterlingChem as new faculty @UTDChemBio. Alistair brings in world-class expertise in computational chemistry with a focus on catalysis, molecular editing, and polymer upcycling. Very exciting!Welcome to UTD, Alistair!.
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Great to host in our lab a group of talented and enthusiastic high school students (@WelchFoundation Summer Scholars) for a hands-on workshop on biocatalysis at @UTDallasChemBio Big shout-out to @Anwita_Ch and @JuanDavidV24 for organizing a cool and engaging workshop!
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On the International Women’s Day, a huge thank to all the women of the @FasanLab @UTDallasChemBio for their outstanding contributions to science, teaching and STEM outreach in our community! Go Pamela, Anwita, Ru, Michelle, Sumana, Mary, Shreya and Francesca! 🦾🦾🎉🎉
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Excited to share our paper on stereoselective synthesis of sp3-rich molecules via enzymatic carbene transfer in @NatureChemistry!Kudos to @davidvarchem Xinkun Ren @arkaseng Ledong Zhu @Satyajit_chem and great collab with @MarcGBQ @houk1000!@UTDallasChemBio
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RT @EnzymeChemistry: #Biocatalytic strategy for the construction of sp3-rich polycyclic compounds by @davidvarchem, Xinkun Ren, @arkaseng,….
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