Elena Moreno-Olmedo
@elenmol2
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RadOnc-OUH Clinical uro-consultant @NHSEngland/ Research Fellow at @Genesiscare. AdaptiveRT. MRIguided.HDR-BT. SABR. Prostate, Gyn, H&N, Oligomets.
Oxford, England
Joined April 2018
STOPCAP at #ESMO26 Benefit of #radiotherapy in de novo M1 #prostatecancer on OS & PFS. Restricted to <5 bone or low volume mets on conventional imaging. No interaction with other patient/tumor characteristics.
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As expected people resist letting go of dogma. Lets review the common examples people grasp at: 1. Nodal field size: cited as why GETUG01 was negative (S1/S2), then cited why RTOG 9413 was negative (L5/S1), then POP-RT positive (L4/L5), but definitive trial of RTOG 0924 (L4/L5)
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Critically important. We have 2 RCTs addressing this question: @GiulioFrancoli1 #ARTO (MDT + abi > abi) and T Niazi #PCS IX (MDT + Enza > Enza) Also have #EXTEND and #RADIOSA showing MDT + ADT > ADT or MDT in mHSCP. In my mind leading question is doublet ARPI + MDT in mHSPC
Another proof that metastasis directed therapy improves outcomes, this time in castration resistant #prostatecancer Congrats to the PCS IX team! author link at @TheLancetOncol: https://t.co/SLt68cCuQP
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Continuous Androgen Deprivation Therapy with or Without Metastasis-directed Therapy for Oligometastatic Prostate Cancer: The Multicenter Phase 2 Randomized EXTEND Trial https://t.co/KjTveZpQcf The phase 2 EXTEND trial showed that in patients with oligometastatic #ProstateCancer
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High-risk prostate cancer patients had a significantly lower incidence of distant metastasis with a radiotherapy-based treatment strategy than with a prostatectomy-based treatment #radonc #pcsm
https://t.co/MAaCYKkfXU
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MR- vs CT-guided: nearly half GU toxicity!!💥💥💥
📢 New in European Urology @AmarUKishan et al: 🎯 MRI-guided SBRT for prostate cancer significantly reduces late GU and GI toxicity vs CT-guided SBRT at 2 years! 🔬 In the MIRAGE RCT, MRI guidance with tighter margins (2 mm) halved GU toxicity (27% vs 51%) and markedly reduced
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📢 New in European Urology @AmarUKishan et al: 🎯 MRI-guided SBRT for prostate cancer significantly reduces late GU and GI toxicity vs CT-guided SBRT at 2 years! 🔬 In the MIRAGE RCT, MRI guidance with tighter margins (2 mm) halved GU toxicity (27% vs 51%) and markedly reduced
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📢The experience from @RadioterapiaHM is just out!! 🎯Clinician- And Patient-Reported Outcomes Of Stereotactic Ablative Radiotherapy For High-Risk Prostate Cancer #radonc #pcsm #SABR
https://t.co/e0vflOqcPC
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🧾 New Cheat Sheet on Prostate Cancer Treatment by Stage 🔹 Low-risk: Active surveillance; avoid ADT 🔹 Intermediate-risk: Surgery or RT; ADT case-based 🔹 High-risk: Surgery/RT + long-term ADT #EAUguidelines #ProstateCancer Download Cheat Sheet here: https://t.co/IvTGHuFWt6
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📢This might just be THE DEFINITIVE meta-analysis of PSMA PET for #prostatecancer recurrence. 🚨Meta-analysis of 43 studies (n=8,119) ⬆️Sensitivity from 48% at PSA 0.2–0.5 ng/ml to >90% at PSA >2. Congrats @declangmurphy @drMPerera + team @Uroweb! ➡️link https://t.co/VYvAn6kli1
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Proud to see EMERALD Trial findings presented at #ESTRO2025 by Dr. Somnath Mukherjee! Watch this short video from @drjamesgood to discover how MR-guided SABR is transforming pancreatic cancer treatment 🎥 Click to download ESTRO presentation 👉🏽 https://t.co/nU6gPp3eE5
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That’s a wrap #ESTRO25! @ESTRO_RT Proud to see the hard work&commitement of the @GenesisCare to providing experience-based evidence in the pursuit of clinical improvement! Here our contribution to #SMART using MRIdian on #upperGI
linkedin.com
🎬That’s a wrap! European Society for Radiotherapy and Oncology (ESTRO) Such a productive and inspiring #ESTRO25 — always a pleasure to catch up with friends, colleagues, and mentors. Proud to see...
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SBRT + 💊 in oligomets: 🧍♂️2294 pts | 🫁, breast, prostate, colorectal ⚠️Grade 3+ AEs: 1.5% ✅ SBRT Safe with systemic tx! #SBRT #OligoCare #ESTRO25 @EORTC @ESTRO_RT @CiroFranzese1
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☢️For those interested in more technical details, don’t miss our dosimetric poster (E25-3471)!!
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Massive thanks for the support and collaboration to @GenesisCare UK , @UniofOxford and @NHSEngland (OUH)
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💎 EMERALD trial in #ESTRO25 Congratulations Dr. Mukherjee for excellent presentation! Honored to have worked w/you. 🎯 3-arm safety trial investigating #SMART in localised #PancreaticCancer (50 Gy/5, 39 Gy/3, 25 Gy/1) 👏🏽Big shout-out to all authors @GenesisCare @UniofOxford
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🚨10y results of HYPO RT PC at #ESTRO25 Hypofractionated #prostatecancer RT (42,7/7) vs conv fractionated RT 1. Non inferior for FFS (even better?) 2. Similar bPFS, DMFS, ADT use, OS 3. Similar GU/GI tox (except transient flare at 1y for UHF)
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Kudos @RadioterapiaHM !!!
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