Daehan Lee
@elegant_DLee
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Geneticist. Postdoc. Studying evolution with model species and their relatives. @Unil
Joined May 2018
Evolutionary genetics of partial selfers is deeply weird and mysterious, but a little less so now that @ecandersen has turned the power of C. elegans to the question. Beautiful creative work from @elegant_DLee @sdraljefainc @Lewis17Stevens et al.
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Wow incredible work in this preprint - I’m glad for all the rotten fruit collections @wormsrock and other made in the pursuit of finding diverse C.elegans. This genome study looks amazing.
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What's in the dark matter? What's the origin? Why have they been maintained? What about other species? Read our preprint https://t.co/OGZu7h8wac to find out! (5/5)
biorxiv.org
The mating system of a species profoundly influences its evolutionary trajectory[1][1]–[3][2]. Across diverse taxa, selfing species have evolved independently from outcrossing species thousands of...
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This dark matter consists of hyper-divergent haplotypes that are commonly shared by wild strains across the globe, frequently contain haplotype-specific genes and, surprisingly, harbor divergence comparable to that of between species that diverged millions of years ago. (4/5)
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Furthermore, we discovered a large amount of "dark matter" in punctuated hyper-divergent regions of wild C. elegans genomes. (3/5)
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First, we found more clues for the origin of this elegant cosmopolitan species. Pacific seems to be the Africa of C. elegans. (2/5)
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Finally, my second paper at @ecandersen lab is now on bioRxiv! Through fantastic teamwork with @sdraljefainc and @Lewis17Stevens, we found something exciting from 328 wild genomes (including long-read assemblies of 15 genomes) of C. elegans species. (Yes, that C. elegans). (1/5)
Balancing selection maintains ancient genetic diversity in C. elegans https://t.co/bJ1ZTigfa3
#biorxiv_evobio
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We've been fascinated by a few diverse C. elegans strains on the Hawaiian islands. In an effort to find more of them and investigate natural niches, my lab deeply sampled the islands. Here is what we found:
biorxiv.org
Recent efforts to understand the natural niche of the keystone model organism Caenorhabditis elegans have suggested that this species is cosmopolitan and associated with rotting vegetation and...
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Nooo grandpa Syd! Thanks for all you did for science. RIP
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The preprint of my first manuscript at Andersen lab(@ecandersen) is now on @biorxiv_evobio! We found that a niche-associated copy-number variation (CNV) of pheromone receptor genes contributes to natural differences in dauer-pheromone responses.
biorxiv.org
From quorum sensing in bacteria to pheromone signaling in social insects, chemical communication mediates interactions among individuals in a local population. In Caenorhabditis elegans , ascaroside...
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Submitted my first-author paper! Check out the preprint. I got to name a gene!!
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My little L2 just discovered her hands. Time to practice ‘fire together wire together’.
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My pretty little L1 just hatched!!! Thanks for @ecandersen lab ( @shaneenz28 @sdraljefainc and many others) for this lovely baby cuticles!! Look forward to seeing next molt. Life cycle must go on!
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Work finally out from @sdraljefainc and others in my group!
New research from @ecandersen et al. Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles https://t.co/6W0nmiTyQ8
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comprehensive review on developmental evolution in Caenorhabditis by Haag, Fitch and Delattre - Wormbook @GeneticsGSA
From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.
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"Directed evolution" techniques which could lead to cancer treatments and environmentally friendly chemicals are at the center of this year's Nobel Prize in Chemistry:
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Robust and sensitive GFP-based cGMP sensor for real time imaging in intact Caenorhabditis elegans
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